DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR2 and LRP12

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_038465.1	Gene:	LRP12 / 29967	HGNCID:	31708	Length:	859	Species:	Homo sapiens

Alignment Length:	800	Identity:	193/800 - (24%)
Similarity:	264/800 - (33%)	Gaps:	292/800 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SSFHLLFITCILSISKFCNAAAVNAAHVTAATPTASEIMHNLSGSALLERLKASTLGPTLDQLKH 133
            |:..|||:..:     :.|.|.  |.|        ||.:| :||       .::..|.|.:|::
Human    15 SALLLLFLAGV-----YGNGAL--AEH--------SENVH-ISG-------VSTACGETPEQIR- 55

  Fly   134 LAPAAANSISPGTGSGMGIGMGHFGSSINS--VLNGNPLKFLNVS-------GKIGTPLDISLGL 189
             ||:...: |||..|       .:.:.||.  .:..||.:.:.:|       |.....|| .|.:
Human    56 -APSGIIT-SPGWPS-------EYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLD-WLTI 110

  Fly   190 SNYCDEKQFQCSTGECIP-----------IRFVCDGSSDCPDHSDERLEECKF---------TES 234
            ..|.:.:.:: :.|..||           |||          |||:.:....|         .|.
Human   111 ETYKNIESYR-ACGSTIPPPYISSQDHIWIRF----------HSDDNISRKGFRLAYFSGKSEEP 164

  Fly   235 TCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHT----------CSPEEFACKSGEG 289
            .|:.:|||||||||||..|.|:..::|.|.|||..  |....          |:..:|.|.|...
Human   165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQCLSRFT 227

  Fly   290 E---CIPLSWMCDQNKDCRDGSDEAQCN-RTC-----------RSDEF--------TC------G 325
            :   |:|.|..||.|.||.|..||..|: .||           .|..:        .|      |
Human   228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 292

  Fly   326 NGRCIQNRFKCDDDDDCG--------DGSDEKN-----------------------------CGE 353
            :.|.:..||.....|..|        ||.:|..                             |.:
Human   293 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCAD 357

  Fly   354 KAKCGSNFFAC--KSGPCIP-------------NQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAG 403
            |......|.|.  ..|.|:|             .|..|||...|.||.|| .|||:     ||..
Human   358 KVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE-TNCTM-----CQKE 416

  Fly   404 EFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCA 468
            ||.||....|..:|..|:.:..||:|.||  .||.  .|:|..|.|.:..|:.....|:.:.||.
Human   417 EFPCSRNGVCYPRSDRCNYQNHCPNGSDE--KNCF--FCQPGNFHCKNNRCVFESWVCDSQDDCG 477

  Fly   469 DGSDEIMCDISATPRTCNATT--EFDCGGGLCIPNAKVCN-----------------------RR 508
            |||||..|.:....|...|..  ...||..|.|.....|.                       .|
Human   478 DGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLR 542

  Fly   509 KDCPNG-------------EDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQH 560
            ::.|..             ||.|.  |..|:.|...        ||.:..|.:      ||   .
Human   543 REAPPSYGQLIAQGLIPPVEDFPV--CSPNQASVLE--------NLRLAVRSQ------LG---F 588

  Fly   561 TCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLL------------------KNHTRCKASE 607
            |.|.:   ...|..|.:. |.|..|.....:|.:.|:                  :|||
Human   589 TSVRL---PMAGRSSNIW-NRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHT------ 643

  Fly   608 GHASLLLARRHDI-----RK--------IALDRPEM---TSIVNSTKAATALDFVFRTGMIFWSD 656
             |.||......|.     |:        :|...|:.   |:.|.:|..|.|             .
Human   644 -HRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACA-------------S 694

  Fly   657 VATQSIYKAPIDEGNDRTVV 676
            .:|||......|.|.|.|.|
Human   695 SSTQSTRGGHADNGRDVTSV 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	8/41 (20%)
		LDLa	235..267	CDD:197566	17/31 (55%)
		LDLa	277..313	CDD:238060	15/38 (39%)
		LDLa	356..388	CDD:197566	12/46 (26%)
		LDLa	400..432	CDD:197566	12/31 (39%)
		LDLa	442..476	CDD:238060	13/33 (39%)
		LDLa	484..517	CDD:197566	9/70 (13%)
		FXa_inhibition	527..562	CDD:291342	6/34 (18%)
		EGF_CA	564..594	CDD:214542	6/29 (21%)
		LY	675..715	CDD:214531	0/1 (0%)
		LY	717..760	CDD:214531
		LY	763..803	CDD:214531
		FXa_inhibition	877..918	CDD:291342
LRP12	NP_038465.1	CUB	47..158	CDD:238001	29/132 (22%)
		LDLa	166..200	CDD:238060	19/35 (54%)
		LDLa	215..254	CDD:238060	15/38 (39%)
		CUB	267..371	CDD:238001	15/103 (15%)
		LDLa	375..410	CDD:238060	11/35 (31%)
		LDLa	413..448	CDD:238060	14/36 (39%)
		LDLa	451..485	CDD:238060	13/33 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..678		10/61 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900