DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR2 and Lrp5

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_001099791.2	Gene:	Lrp5 / 293649	RGDID:	1309329	Length:	1600	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	131/321 - (40%)
Similarity:	189/321 - (58%)	Gaps:	13/321 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 CKASEGHAS--LLLARRHDIRKIALD--RPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIY 663
            |......||  ||.|.|.|:|.:...  :.|.|.:.:..:.|.|:||.|..|.::|:||:.::|.
  Rat    24 CSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIK 88

  Fly   664 KAPIDE-GNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIP 727
            :..::: |.....::....|:.||||.||:...:|:||:....||:.|..|:..|||....||.|
  Rat    89 QTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQP 153

  Fly   728 RSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNT 792
            |:|||||..|:|||:|||.:||||||||||:.|..|:..|:.||||:|:||.:::|||.|.||:.
  Rat   154 RAIALDPAHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF 218

  Fly   793 ISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLE 857
            |..:|.|||.|.:|:...  |.|||::|...|.:|||||..:::...||:.|...:.:.:.  |.
  Rat   219 IHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILSA--LY 279

  Fly   858 HPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMC 918
            .||.:.|....|||.....|:..||.||||||.:|    |.|..|||||||::|..:|..|
  Rat   280 SPMDIQVLSQERQPPFHTPCEEGNGGCSHLCLLSP----REPFYSCACPTGVQLQDNGKTC 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566
		LDLa	277..313	CDD:238060
		LDLa	356..388	CDD:197566
		LDLa	400..432	CDD:197566
		LDLa	442..476	CDD:238060
		LDLa	484..517	CDD:197566
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531	14/39 (36%)
		LY	717..760	CDD:214531	29/42 (69%)
		LY	763..803	CDD:214531	20/39 (51%)
		FXa_inhibition	877..918	CDD:291342	21/40 (53%)
Lrp5	NP_001099791.2	NHL	<37..>169	CDD:302697	47/131 (36%)
		NHL repeat	65..104	CDD:271320	11/38 (29%)
		LY	102..142	CDD:214531	14/39 (36%)
		NHL repeat	107..148	CDD:271320	17/40 (43%)
		Ldl_recept_b	163..203	CDD:278487	25/39 (64%)
		LY	187..229	CDD:214531	20/41 (49%)
		LY	230..271	CDD:214531	15/42 (36%)
		FXa_inhibition	299..336	CDD:291342	21/40 (53%)
		LY	366..406	CDD:214531
		LY	408..450	CDD:214531
		LY	451..494	CDD:214531
		LY	495..537	CDD:214531
		LY	538..571	CDD:214531
		FXa_inhibition	605..640	CDD:291342
		NHL	685..878	CDD:302697
		LY	710..752	CDD:214531
		NHL repeat	720..756	CDD:271320
		NHL repeat	763..802	CDD:271320
		NHL repeat	808..843	CDD:271320
		NHL repeat	847..871	CDD:271320
		FXa_inhibition	906..941	CDD:291342
		LY	1060..1103	CDD:214531
		LY	1104..1146	CDD:214531
		FXa_inhibition	1217..1253	CDD:291342
		LDLa	1259..1295	CDD:238060
		LDLa	1321..1355	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810