Protein Alignment LpR2 and LpR1

DIOPT Version :10

• Sequence 1: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Sequence 2: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Alignment Length: 1124
• Identity: 691/1124 - (61%)
• Similarity: 793/1124 - (70%)
• Gaps: 163/1124 - (14%)

  Fly    29 SRSSSSSSGCREPSKTSGFFYSASTHYQSKV-----------QQLISFSFTSSFHLLFITCILSI 82
            |||:|::|   |.:||:   ..::|..:|.|           :||...: .::|:||.:|.:|..
  Fly     5 SRSTSTAS---ETTKTA---IKSTTSSKSPVTFGNLGEKRRAEQLFRCA-CANFNLLLLTLMLGF 62

  Fly    83 SKFCNAAAVNAAHVTAATPTASEIMHNLSGSALLERLKASTLGPTLDQLKHLAPAAANSISPGTG 147
            .|.|.|........:..|||::...||               ..|||:
  Fly    63 GKCCTATPTPLNTPSTNTPTSAVSPHN---------------PQTLDE----------------- 95

  Fly   148 SGMGIGMGHFGSSINSVLNGNP-----LKFLNVSGKIGTPLDISLGLSNYCDEKQFQCSTGECIP 207
            ||          |::.|::|..     .|||||||||||||.|...|...||||||||.:|:|||
  Fly    96 SG----------SLSKVIDGKAFINMGFKFLNVSGKIGTPLGIGQSLEAKCDEKQFQCHSGDCIP 150

  Fly   208 IRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDEST--- 269
            |||||||.:||.|||||:::||||.|:|||.:|||||||.|||.:|.||:|:||||||||:.
  Fly   151 IRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELC 215

  Fly   270 ------------------------------------SQCRSHTCSPEEFACKSGEGECIPLSWMC 298
                                                :.||:.||||:|:|||||||:|:||:|||
  Fly   216 MNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHCRARTCSPDEYACKSGEGQCVPLAWMC 280

  Fly   299 DQNKDCRDGSDEAQCNRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGS-NFF 362
            ||:|||.|||||..||:|||:||||||||||||.|:|||.|||||||||||.| ....|.| ...
  Fly   281 DQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKEC-PVVPCDSVAEH 344

  Fly   363 ACKSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNF-CQAGEFQCSDRITCLHKSWVCDGEADC 426
            .|.:|.||..:||||||.||.:|.||.....|:.... |.:.|:||.|||||||.||:|||:.||
  Fly   345 TCTNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDC 409

  Fly   427 PDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISAT----PRTCNA 487
            |||:||..:||..|:||.|||||.|:|||.|||||||.:||||||||..|.:|.:    ...|||
  Fly   410 PDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNA 474

  Fly   488 TTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDG 552
            |:|||||||.|:|.:|||::|||||:||||||||||||||:||||||||||::|:||:.||||:|
  Fly   475 TSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEG 539

  Fly   553 YKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARR 617
            |||..|:..|.||:|||.||.|||:||||||.|||||||||||..||||||||||||||||||||
  Fly   540 YKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARR 604

  Fly   618 HDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSV 682
            |||||||||..|||||||||||||||||||||||||||||.|||||||||||||::|||||||||
  Fly   605 HDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSV 669

  Fly   683 TSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS 747
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   670 TSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS 734

  Fly   748 PRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEY 812
            ||||||||||:|||.||:||||||||||||||:||:||||||||.|||:|||||||.||||||||
  Fly   735 PRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEY 799

  Fly   813 LRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHC 877
            ||||||||||||.|||||||||||||||||.|.|||||||.|||:||||||||||||||||||||
  Fly   800 LRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHC 864

  Fly   878 QSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVED-LGIPTV-----------RPT 930
            |||||||||||||||||||||||||||||||||||.|||||||| |.:|.|           ||.
  Fly   865 QSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKPRPK 929

  Fly   931 APMHR--------------TIEQSSNSTTKLP-------QDGYSETPVETKTGNNRTDTSNQVHK 974
            :|..|              .|......:|:||       .|   :.||:..|         |:.|
  Fly   930 SPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVAD---QRPVKNHT---------QIEK 982

  Fly   975 SDAESEN-DYVEIALHVIASLAGTALVASVIYVV-YRRCT-RAVNSMNFENPVYHK--TTEDHFS 1034
            :...||. |...|||.|||||:|.|::.||:.:: ||.|: |.:||||||||:|.|  |||||||
  Fly   983 TTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDHFS 1047

  Fly  1035 LEKNGTPHIY--AAANDEE 1051
            |.||....||  .:..|||
  Fly  1048 LRKNLPARIYDHTSVMDEE 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	24/30 (80%)
		LDLa	235..267	CDD:197566	23/31 (74%)
		LDLa	277..313	CDD:238060	27/35 (77%)
		LDLa	356..388	CDD:197566	15/32 (47%)
		LDLa	400..432	CDD:197566	21/31 (68%)
		LDLa	442..476	CDD:238060	26/33 (79%)
		LDLa	484..517	CDD:197566	23/32 (72%)
		FXa_inhibition	527..562	CDD:464251	23/34 (68%)
		EGF_CA	564..594	CDD:214542	24/29 (83%)
		LY	675..715	CDD:214531	39/39 (100%)
		LY	717..760	CDD:214531	41/42 (98%)
		LY	763..803	CDD:214531	34/39 (87%)
		Ldl_recept_b	782..828	CDD:459654	40/45 (89%)
		Ldl_recept_b	824..866	CDD:459654	36/41 (88%)
		FXa_inhibition	877..918	CDD:464251	39/40 (98%)
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	24/31 (77%)
		LDLa	178..210	CDD:197566	23/31 (74%)
		LDLa	219..254	CDD:238060	0/34 (0%)
		LDLa	259..295	CDD:238060	27/35 (77%)
		LDLa	343..373	CDD:238060	15/29 (52%)
		LDLa	383..415	CDD:197566	21/31 (68%)
		Ldl_recept_a	423..459	CDD:395011	27/35 (77%)
		LDLa	476..504	CDD:197566	19/27 (70%)
		FXa_inhibition	514..549	CDD:464251	23/34 (68%)
		EGF_CA	551..581	CDD:214542	24/29 (83%)
		LY	662..702	CDD:214531	39/39 (100%)
		LY	704..747	CDD:214531	41/42 (98%)
		LY	749..790	CDD:214531	34/40 (85%)
		Ldl_recept_b	769..815	CDD:459654	40/45 (89%)
		FXa_inhibition	864..905	CDD:464251	39/40 (98%)