DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and LRP10

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:XP_005267567.1 Gene:LRP10 / 26020 HGNCID:14553 Length:721 Species:Homo sapiens


Alignment Length:360 Identity:88/360 - (24%)
Similarity:116/360 - (32%) Gaps:125/360 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 CSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEF------------------ 282
            |.||:|:|.|.:|:.....||..:.|.|||||:       .||.:.|                  
Human   148 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEA-------GCSSDPFPGLTPRPVPSLPCNVTLE 205

  Fly   283 --------------ACKSGEGECIPLSWMCDQNKDCR-------------------DGSDEAQCN 314
                          |..|....|   .|:.|.:...|                   ||....:.:
Human   206 DFYGVFSSPGYTHLASVSHPQSC---HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESS 267

  Fly   315 RTCRS-DEFTCG----------------------NGRCIQNRFKCDD-----DDDCGDGSD---E 348
            |..|| ..|:.|                      |||.....:....     |..||.||.   .
Human   268 RLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAG 332

  Fly   349 KNCGEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQC-----S 408
            :..||:              |......|||..||.:|.|| ::|.     .|..|.|.|     |
Human   333 EGLGER--------------CYSEAQRCDGSWDCADGTDE-EDCP-----GCPPGHFPCGAAGTS 377

  Fly   409 DRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDE 473
            ....|...:..|:.:..|.||.||.:..    .|:|..|:|.|:.|:.....|:|:.||||||||
Human   378 GATACYLPADRCNYQTFCADGADERRCR----HCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 438

  Fly   474 IMCDISATPR---TCNATTEFDCGGGLCIPNAKVC 505
            ..|.. ..||   |........||..|.|.....|
Human   439 WDCSY-VLPRKVITAAVIGSLVCGLLLVIALGCTC 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566
LDLa 235..267 CDD:197566 13/30 (43%)
LDLa 277..313 CDD:238060 11/86 (13%)
LDLa 356..388 CDD:197566 7/31 (23%)
LDLa 400..432 CDD:197566 10/36 (28%)
LDLa 442..476 CDD:238060 16/33 (48%)
LDLa 484..517 CDD:197566 6/22 (27%)
FXa_inhibition 527..562 CDD:291342
EGF_CA 564..594 CDD:214542
LY 675..715 CDD:214531
LY 717..760 CDD:214531
LY 763..803 CDD:214531
FXa_inhibition 877..918 CDD:291342
LRP10XP_005267567.1 CUB 34..134 CDD:238001
LDLa 148..182 CDD:238060 15/40 (38%)
CUB 200..310 CDD:238001 16/112 (14%)
LDLa <338..361 CDD:238060 9/37 (24%)
LDLa 407..441 CDD:238060 16/33 (48%)
PRK04654 <581..683 CDD:135173
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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