DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and Lrp4

DIOPT Version :10

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:NP_766256.3 Gene:Lrp4 / 228357 MGIID:2442252 Length:1905 Species:Mus musculus


Alignment Length:858 Identity:340/858 - (39%)
Similarity:459/858 - (53%) Gaps:88/858 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 ISLGLSNYCDEKQFQCST---GE--CIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCG 244
            |:..|...|....|.|:.   ||  |||.::.|||.:||.|||||  :.|  |..|||...|.|.
Mouse    19 IASSLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDE--DGC--TLPTCSPLDFHCD 79

  Fly   245 NGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSD 309
            |||||.|.||||.:|||.|.|||  ..|....|..:||.|::  |.||...|.||.:.||.|.||
Mouse    80 NGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPCQN--GYCIRSLWHCDGDNDCGDNSD 140

  Fly   310 EAQCN-RTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGE---KAKCGSNFFACKSGPCI 370
            | ||: |.|...||.|.:|.||...:.||.|.||.|||||::|..   ...|....|.|..|.||
Mouse   141 E-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRCI 204

  Fly   371 PNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQS 435
            .:.:.||||.||.:..|| .:|  |....|::|||.| |...|::..|.|||:|||.|..||  .
Mouse   205 LDIYHCDGDDDCGDWSDE-SDC--SSHQPCRSGEFMC-DSGLCINSGWRCDGDADCDDQSDE--R 263

  Fly   436 NCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIP 500
            ||....|..:||:|....|:.....|:|:.||||.|||..|:.:.:|: | |:.:|.|..|.||.
Mouse   264 NCTTSMCTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQ-C-ASDQFLCWNGRCIG 326

  Fly   501 NAKVCNRRKDCPNGEDE-PAGKC----GINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQH 560
            ..|:||...||.:..|| |...|    |...|:..||||..:|..:....:|.||.||:|..|..
Mouse   327 QRKLCNGINDCGDSSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGR 391

  Fly   561 TCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIAL 625
            ||.|::||...|.|||.|.|..|||:|.||||| .|..:...|||......||.|.|.|||::..
Mouse   392 TCQDVNECAEEGYCSQGCTNTEGAFQCWCEAGY-ELRPDRRSCKALGPEPVLLFANRIDIRQVLP 455

  Fly   626 DRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVD 690
            .|.|.|.::|:.:.|.||||..|..::|||||....|.:|.::..|...||.| ...:..|||||
Mouse   456 HRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVST-GLESPGGLAVD 519

  Fly   691 WIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGM 755
            |:::.:|:||:....||:.|.:|:..|||:..||:.||:|||.|:||.:||:|||.:||||.:.|
Mouse   520 WVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSM 584

  Fly   756 DGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSIT 820
            ||:.|..|....:.||||:|:|...:|:||||.|.:.|..:|.|||.|..|:..|  |.|||:||
Mouse   585 DGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAIT 647

  Fly   821 TFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCS 885
            .|||.:|||||..:::..||||.|.:.|.:  .:.|..||.:|..||.|||.|.|.|...||.|:
Mouse   648 VFEDSLYWTDWHTKSINSANKFTGKNQEII--RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCT 710

  Fly   886 HLCLPAPRINERSPRISCACPTGLKLMPDGLMC----------------------VEDLGIPTVR 928
            |||||:      ....:||||||.:.: :...|                      .|||. ..|.
Mouse   711 HLCLPS------GQNYTCACPTGFRKI-NSHACAQSLDKFLLFARRMDIRRISFDTEDLS-DDVI 767

  Fly   929 PTAPMHRTI--------------EQSSNSTTKLPQDGYS-----ETPVETKTGNNRTDTSNQVHK 974
            |.|.:...:              :.|:::.::...||..     :|.:|:..|......:|:::.
Mouse   768 PLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYW 832

  Fly   975 SDAESENDYVEIA 987
            :||.:  |.:|:|
Mouse   833 TDAGT--DRIEVA 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 16/35 (46%)
LDLa 235..267 CDD:197566 20/31 (65%)
LDLa 277..313 CDD:238060 16/35 (46%)
LDLa 356..388 CDD:197566 12/31 (39%)
LDLa 400..432 CDD:197566 15/31 (48%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 484..517 CDD:197566 12/32 (38%)
FXa_inhibition 527..562 CDD:464251 13/34 (38%)
EGF_CA 564..594 CDD:214542 17/29 (59%)
LY 675..715 CDD:214531 16/39 (41%)
LY 717..760 CDD:214531 25/42 (60%)
LY 763..803 CDD:214531 18/39 (46%)
Ldl_recept_b 782..828 CDD:459654 23/45 (51%)
Ldl_recept_b 824..866 CDD:459654 16/41 (39%)
FXa_inhibition 877..918 CDD:464251 15/40 (38%)
Lrp4NP_766256.3 LDLa 27..66 CDD:238060 18/40 (45%)
Ldl_recept_a 70..105 CDD:395011 22/36 (61%)
LDLa 110..142 CDD:238060 16/34 (47%)
LDLa 148..182 CDD:238060 17/33 (52%)
LDLa 231..265 CDD:238060 17/36 (47%)
LDLa 270..304 CDD:238060 14/33 (42%)
LDLa 311..343 CDD:197566 12/33 (36%)
FXa_inhibition 358..393 CDD:464251 13/34 (38%)
EGF_CA 395..434 CDD:214542 19/39 (49%)
LY 460..502 CDD:214531 15/41 (37%)
LDL-receptor class B 1 480..522 17/42 (40%)
LY 505..545 CDD:214531 16/40 (40%)
LDL-receptor class B 2 523..565 18/41 (44%)
LDL-receptor class B 3 566..609 21/42 (50%)
Ldl_recept_b 566..607 CDD:459654 20/40 (50%)
LY 590..632 CDD:214531 18/41 (44%)
LDL-receptor class B 4 610..652 22/43 (51%)
LY 633..673 CDD:214531 21/41 (51%)
LDL-receptor class B 5 653..693 16/41 (39%)
FXa_inhibition 702..>729 CDD:464251 15/32 (47%)
YncE 749..982 CDD:442618 18/98 (18%)
LDL-receptor class B 6 785..827 6/41 (15%)
LY 808..850 CDD:214531 9/38 (24%)
LDL-receptor class B 7 828..870 6/18 (33%)
LDL-receptor class B 8 871..914
Ldl_recept_b 871..912 CDD:459654
LY 895..937 CDD:214531
LDL-receptor class B 9 915..956
LDL-receptor class B 10 957..998
FXa_inhibition 1006..1043 CDD:464251
NHL <1085..1277 CDD:302697
NHL repeat 1085..1123 CDD:271320
LDL-receptor class B 11 1093..1135
NHL repeat 1128..1161 CDD:271320
LDL-receptor class B 12 1136..1178
NHL repeat 1166..1203 CDD:271320
LDL-receptor class B 13 1179..1222
Ldl_recept_b 1179..1219 CDD:459654
NHL repeat 1212..1244 CDD:271320
LDL-receptor class B 14 1223..1263
NHL repeat 1253..1277 CDD:271320
LDL-receptor class B 15 1264..1306
FXa_inhibition 1313..1348 CDD:464251
Vgb 1359..1583 CDD:443399
LDL-receptor class B 16 1397..1439
LDL-receptor class B 17 1440..1482
LDL-receptor class B 18 1483..1526
Ldl_recept_b 1483..1524 CDD:459654
LY 1507..1547 CDD:214531
LDL-receptor class B 19 1527..1568
LDL-receptor class B 20 1569..1610
FXa_inhibition 1617..1648 CDD:464251
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.

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