DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and EGF

DIOPT Version :10

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:NP_001954.2 Gene:EGF / 1950 HGNCID:3229 Length:1207 Species:Homo sapiens


Alignment Length:638 Identity:175/638 - (27%)
Similarity:274/638 - (42%) Gaps:116/638 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   414 LHKSWVCDGEADC------PDGEDES-----------QSNCLKVSCRPDQFQCNDQSCIAGHLTC 461
            ||.|:|..||...      |..||::           :.||....|..| .|.:...|..|:...
Human   285 LHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQD-LQSHLCMCAEGYALS 348

  Fly   462 NGKRDCADGSDEIMCDISATPRTCNATTEFDCG---GGLCIPNAKVCNRRKDCPNGEDEPAGKCG 523
            ..::.|.|.::....:...|....|....:.|.   |.:.:|:.|.|::...||.         .
Human   349 RDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPR---------N 404

  Fly   524 INECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECETP--GICSQVCV--NEIGA 584
            ::|||       |.||....|..|.|.:|..|..|..||   ..|.:|  |.|||:||  :.: :
Human   405 VSECS-------HDCVLTSEGPLCFCPEGSVLERDGKTC---SGCSSPDNGGCSQLCVPLSPV-S 458

  Fly   585 FKCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSIVNSTKAAT-ALDFVFR 648
            ::|:|..|| .|..:...|.||.....||.|...|||.:..|..:..::::...... |||....
Human   459 WECDCFPGY-DLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPV 522

  Fly   649 TGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEG 713
            ...|:::..|.:.|.:|.:| |:.|..::.:.....:|||||||....|:||..|..|..::..|
Human   523 ENKIYFAHTALKWIERANMD-GSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNG 586

  Fly   714 SMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDL 778
            ...|::.|:::..||.||:.|:...::|:|.|.:||||.:.:.|..|..|.:.|:.||:|||:|.
Human   587 KRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDF 651

  Fly   779 VQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFN 843
            :..:|||.|.|.:.|..:|.|||:|.::..:.  :.|||::..|||||:::||...:|.:.||..
Human   652 LTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRT 714

  Fly   844 GMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTG 908
            |.|...:..: ||: |..:.|.||..:| |.:.|...||.|.|:|      .:|.....|:|..|
Human   715 GKDRVRLQGS-MLK-PSSLVVVHPLAKP-GADPCLYQNGGCEHIC------KKRLGTAWCSCREG 770

  Fly   909 LKLMPDGLMCVEDLGIPTVRPTAPMHRTIEQSSNSTTKLPQDGYSETPVETKTGNNRTDTSNQVH 973
            .....||..|                            |..||:.      .......|..|||.
Human   771 FMKASDGKTC----------------------------LALDGHQ------LLAGGEVDLKNQVT 801

  Fly   974 KSDAESE----NDYVEIALHVIASLAGTALVASVIY-----------VVYRRC 1011
            ..|..|:    .|.:..:.|:        |||.::.           .:|.||
Human   802 PLDILSKTRVSEDNITESQHM--------LVAEIMVSDQDDCAPVGCSMYARC 846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566
LDLa 235..267 CDD:197566
LDLa 277..313 CDD:238060
LDLa 356..388 CDD:197566
LDLa 400..432 CDD:197566 8/23 (35%)
LDLa 442..476 CDD:238060 7/33 (21%)
LDLa 484..517 CDD:197566 8/35 (23%)
FXa_inhibition 527..562 CDD:464251 11/34 (32%)
EGF_CA 564..594 CDD:214542 11/33 (33%)
LY 675..715 CDD:214531 13/39 (33%)
LY 717..760 CDD:214531 15/42 (36%)
LY 763..803 CDD:214531 18/39 (46%)
Ldl_recept_b 782..828 CDD:459654 19/45 (42%)
Ldl_recept_b 824..866 CDD:459654 14/41 (34%)
FXa_inhibition 877..918 CDD:464251 12/40 (30%)
EGFNP_001954.2 TolB 47..190 CDD:440585
LDL-receptor class B 1 86..127
LDL-receptor class B 2 128..169
LY 152..189 CDD:214531
LDL-receptor class B 3 170..211
LDL-receptor class B 4 212..258
EGF_CA 356..395 CDD:214542 7/38 (18%)
FXa_inhibition 408..436 CDD:464251 11/34 (32%)
FXa_inhibition 439..476 CDD:464251 13/38 (34%)
LDL-receptor class B 5 483..523 10/39 (26%)
LY 505..546 CDD:214531 9/41 (22%)
LDL-receptor class B 6 524..566 13/42 (31%)
LY 547..587 CDD:214531 12/39 (31%)
LDL-receptor class B 7 567..609 13/41 (32%)
LY 590..633 CDD:214531 15/42 (36%)
LDL-receptor class B 8 610..653 17/42 (40%)
LY 635..676 CDD:214531 18/40 (45%)
LDL-receptor class B 9 654..696 16/43 (37%)
LY 677..718 CDD:214531 14/42 (33%)
FXa_inhibition 745..780 CDD:464251 12/40 (30%)
O-glycosylated at one site 801..807 1/5 (20%)
EGF 835..864 CDD:394967 3/12 (25%)
EGF_CA 870..910 CDD:214542
EGF_CA 912..940 CDD:429571
PHA03099 <976..>1014 CDD:165381
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1108..1131
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1177..1207
Blue background indicates that the domain is not in the aligned region.

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