DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and lrp-2

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:868 Identity:270/868 - (31%)
Similarity:400/868 - (46%) Gaps:164/868 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 CDEKQFQC-STGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCD 256
            |.|.:|:| .:..||.....||..:|||...||..:.|  :...|....|.||||.|||.:.||:
 Worm  2639 CAENEFKCLHSDRCIRYEDTCDRYNDCPMFDDEDTKYC--STRVCRPGYFNCGNGLCIPEQKVCN 2701

  Fly   257 RENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCN-RTCRS- 319
            |.||||:.:||  |.|   ||:..||.|:|  |.|||....|:..:||.|.|||..|. |.|.: 
 Worm  2702 RINDCANFADE--SNC---TCNENEFRCQS--GACIPSKARCNHMQDCNDASDEIGCPFRNCSAL 2759

  Fly   320 DEF------TCG-NGRCIQNRFKCDDDDDCGDGSDEKNC-----------GEKAKCGSNF-FAC- 364
            :||      .|. ..:||...:|||..:||.||||||:|           .....|.:.. ||| 
 Worm  2760 NEFGMTGLINCATTSQCIHPSWKCDGTNDCYDGSDEKDCFVEFDATGGSVSAPRSCDAKTQFACL 2824

  Fly   365 KSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDG 429
            .:..|:|..|.|||..||.:|.|| :||....   |.:.||.|.....|:.....|||..|||||
 Worm  2825 ATRTCMPKHWQCDGQPDCADGSDE-KNCDAKK---CTSFEFSCESSKKCIPLEQKCDGRRDCPDG 2885

  Fly   430 EDESQS-------------NCLKVSCRPDQFQCN------------------------------- 450
            |||.|.             .|....|.|..::|:                               
 Worm  2886 EDEHQCETECDSKGGNATFRCTNHRCIPMAWRCDGTDDCMDNAKSLGSDEVDCAAGRTSFHVPSR 2950

  Fly   451 --DQSC-IAGHLT---CNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPNAKVCNRRK 509
              |::| :|..||   |:|.:||:||.||..|  ::..|.|. ..|:.|..|.||.:.::|:...
 Worm  2951 CADETCVVACELTAVLCDGIQDCSDGFDEKNC--ASLDRQCK-PNEWMCDSGQCIDSGRLCDASV 3012

  Fly   510 DCPNGEDEPAGKCGINE-----------CSSKNG--GCM-----------------HQCVNLE-- 542
            ||.:|.||....|.::|           |...||  ||:                 .||.|.:  
 Worm  3013 DCVDGSDEWVEICSLSEPPRRGCPSGWSCLLTNGTIGCLQEQQLCDGRRDCMSGIDEQCDNPQGN 3077

  Fly   543 -----------------VGYR-CECHDGYKLGA-DQHTCVDIDECETPGICSQVCVN--EIGAFK 586
                             .|:. |.|.|||.|.. |:.||:....|.... ||..|::  ::| .:
 Worm  3078 CSSTRNSCDQTWNCQRHAGFESCSCDDGYHLSPYDKKTCLRSPSCPKAN-CSHFCIDRRDVG-HQ 3140

  Fly   587 CECEAGYMRLLKNHTRCKASEG-HASLLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTG 650
            |.|..||: |.:|...|:.::. .|.:|:...|.::...:|.....:::::.....|||:..::.
 Worm  3141 CFCAPGYI-LSENQKDCRRNDTIEAEILMVYGHRLKLFTIDGHAKATLLSNLTNGVALDYDVKSD 3204

  Fly   651 MIFWSDVATQSIYKAPI----DEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNF 711
            :::|:|||... .||.|    ::.|...|:.:..:...||:||||:..::|:||.:...|.:.:.
 Worm  3205 LVYWTDVAHDG-NKAGITSMSNQPNTYRVINSLPTKGIDGIAVDWLGRNIYYTDRNHDAIAVCDM 3268

  Fly   712 EGSMGKVLVKDS-LDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAII-TYDVKWPNGI 774
            .|...::|:|.: |:.||:|.|||::..::|:|||||..|.|..|||::...|: ...::|||.:
 Worm  3269 RGRFNRILLKGTPLNDPRAIVLDPLQALVFWTDWGASAHIGRMNMDGSNEQVILQDRTIRWPNAL 3333

  Fly   775 TLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKA 839
            .:|...:|||:.|...:.|:|.|||||:|..||...  :||.|::..|||||||:||....:.:.
 Worm  3334 AVDAPAQRLYFGDAHRDYIASCNYDGSKRRMVLRGS--VRHIFALAVFEDYVYWSDWHNHTIERV 3396

  Fly   840 NKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDG----VNHCQSVNGHCSHLCLPA--PRINERS 898
            :|..|.: ..|........||...:.||..|..|    ..|..|....|.:||:||  |.:...|
 Worm  3397 HKITGTN-RKVLIQDKQYRPMGFKIVHPSLQSMGSLKTARHPCSQPARCDNLCIPANTPDLTTSS 3460

  Fly   899 PRISCACPTGLKLMPDGLMCVED 921
            ...:|.|..|.:  .:|..||.:
 Worm  3461 DNFTCMCAQGFR--SEGRSCVSE 3481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 11/31 (35%)
LDLa 235..267 CDD:197566 16/31 (52%)
LDLa 277..313 CDD:238060 16/35 (46%)
LDLa 356..388 CDD:197566 13/33 (39%)
LDLa 400..432 CDD:197566 14/31 (45%)
LDLa 442..476 CDD:238060 16/70 (23%)
LDLa 484..517 CDD:197566 10/32 (31%)
FXa_inhibition 527..562 CDD:291342 16/74 (22%)
EGF_CA 564..594 CDD:214542 8/31 (26%)
LY 675..715 CDD:214531 12/39 (31%)
LY 717..760 CDD:214531 20/43 (47%)
LY 763..803 CDD:214531 16/40 (40%)
FXa_inhibition 877..918 CDD:291342 12/42 (29%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531
LY 707..758 CDD:214531
LY 759..801 CDD:214531
LDLa 968..1000 CDD:197566
LDLa 1013..1047 CDD:238060
LDLa 1053..1087 CDD:238060
LDLa 1098..1129 CDD:238060
LDLa 1144..1175 CDD:238060
LDLa 1182..1216 CDD:238060
FXa_inhibition 1276..1305 CDD:291342
LY 1421..1463 CDD:214531
LY 1465..1508 CDD:214531
LY 1521..1555 CDD:214531
LY 2480..2521 CDD:214531
LDLa 2681..2715 CDD:238060 19/35 (54%)
LDLa 2717..2751 CDD:238060 16/35 (46%)
LDLa <2774..2798 CDD:238060 13/23 (57%)
LDLa 2819..2851 CDD:238060 14/32 (44%)
LDLa 2856..2891 CDD:238060 16/34 (47%)
LDLa 2904..2938 CDD:238060 4/33 (12%)
LDLa 2988..3020 CDD:197566 10/32 (31%)
LY 3231..3270 CDD:214531 11/38 (29%)
Ldl_recept_b 3296..3336 CDD:278487 15/39 (38%)
LY 3319..3362 CDD:214531 16/42 (38%)
LY 3363..3404 CDD:214531 16/43 (37%)
LDLa 3481..3514 CDD:197566 0/1 (0%)
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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