DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR2 and Lrp5

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_032539.2	Gene:	Lrp5 / 16973	MGIID:	1278315	Length:	1614	Species:	Mus musculus

Alignment Length:	321	Identity:	131/321 - (40%)
Similarity:	189/321 - (58%)	Gaps:	13/321 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 CKASEGHAS--LLLARRHDIRKIALD--RPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIY 663
            |......||  ||.|.|.|:|.:...  :.|.|.:.:..:.|.|:||.|..|.::|:||:.::|.
Mouse    23 CSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIK 87

  Fly   664 KAPIDE-GNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIP 727
            :..::: |.....::....|:.||||.||:...:|:||:....||:.|..|:..|||....||.|
Mouse    88 QTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQP 152

  Fly   728 RSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNT 792
            |:|||||..|:|||:|||.:||||||||||:.|..|:..|:.||||:|:||.:::|||.|.||:.
Mouse   153 RAIALDPAHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF 217

  Fly   793 ISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLE 857
            |..:|.|||.|.:|:...  |.|||::|...|.:|||||..:::...||:.|...:.:.:.  |.
Mouse   218 IHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEQRKEILSA--LY 278

  Fly   858 HPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMC 918
            .||.:.|....|||.....|:..||.||||||.:|    |.|..|||||||::|..:|..|
Mouse   279 SPMDIQVLSQERQPPFHTPCEEDNGGCSHLCLLSP----REPFYSCACPTGVQLQDNGKTC 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566
		LDLa	277..313	CDD:238060
		LDLa	356..388	CDD:197566
		LDLa	400..432	CDD:197566
		LDLa	442..476	CDD:238060
		LDLa	484..517	CDD:197566
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531	14/39 (36%)
		LY	717..760	CDD:214531	29/42 (69%)
		LY	763..803	CDD:214531	20/39 (51%)
		FXa_inhibition	877..918	CDD:291342	21/40 (53%)
Lrp5	NP_032539.2	Beta-propeller 1	31..287		104/259 (40%)
		NHL	<36..>168	CDD:302697	47/131 (36%)
		NHL repeat	64..103	CDD:271320	11/38 (29%)
		LY	101..141	CDD:214531	14/39 (36%)
		NHL repeat	106..147	CDD:271320	17/40 (43%)
		Ldl_recept_b	162..202	CDD:278487	25/39 (64%)
		LY	186..228	CDD:214531	20/41 (49%)
		LY	229..270	CDD:214531	15/42 (36%)
		LDL-receptor class B 5	247..289		13/43 (30%)
		FXa_inhibition	298..335	CDD:291342	21/40 (53%)
		Beta-propeller 2	340..601
		LY	365..405	CDD:214531
		LY	407..449	CDD:214531
		LY	450..493	CDD:214531
		LY	494..536	CDD:214531
		LY	537..570	CDD:214531
		FXa_inhibition	604..639	CDD:291342
		Beta-propeller 3	643..902
		NHL	684..877	CDD:302697
		LY	709..751	CDD:214531
		NHL repeat	719..755	CDD:271320
		NHL repeat	762..801	CDD:271320
		NHL repeat	807..842	CDD:271320
		NHL repeat	846..870	CDD:271320
		FXa_inhibition	905..940	CDD:291342
		Beta-propeller 4	944..1211
		LY	969..1008	CDD:214531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1002..1025
		LY	1059..1102	CDD:214531
		LY	1103..1145	CDD:214531
		FXa_inhibition	1216..1252	CDD:291342
		LDLa	1258..1294	CDD:238060
		LDLa	1297..1331	CDD:238060
		LDLa	1335..1369	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1474..1498
		PPPSP motif A	1499..1505
		PPPSP motif B	1537..1544
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1567..1599
		PPPSP motif C	1573..1580
		PPPSP motif D	1590..1595
		PPPSP motif E	1604..1611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810