DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LpR2 and Dgcr2

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:NP_034178.2 Gene:Dgcr2 / 13356 MGIID:892866 Length:549 Species:Mus musculus


Alignment Length:420 Identity:101/420 - (24%)
Similarity:140/420 - (33%) Gaps:137/420 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   277 CSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCNRTCRSDEFTCGNGR--------CIQNR 333
            |:|.:|||..|..:||||.|.||....|.|.||||.|      .|.| |..|        ..|.|
Mouse    30 CNPGQFACHGGTIQCIPLPWQCDGWPTCEDKSDEADC------PEVT-GEARPYGKETVDLRQGR 87

  Fly   334 FKCDDDDDCGDGSDEK-----NCGEKAKCGSNFFACKSGPCIPNQW-VCDGDSDC----RNGE-- 386
            .:         |.|..     |..:..:..|....|.||      | ..:|.:.|    .:||  
Mouse    88 AR---------GGDPTHFHTVNVAQPVRFSSFLGKCPSG------WHHYEGTASCYRVYLSGENY 137

  Fly   387 -DEMQNC-----------TVSLLNFCQAGEFQCSDRI---TCLHKSWVCDGEADCPDGEDESQSN 436
             |..|.|           |...|.|..|.|:...:|.   ....|.||  |......|.:.|...
Mouse   138 WDAAQTCQRVNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWV--GYQYVITGRNHSLEG 200

  Fly   437 CLKVSCR--PDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPR----------TCNATT 489
            ..:|:.:  |:.|...| ...|..::.|....||    ::.|....|.|          :|:..:
Mouse   201 RWEVAFKGSPEVFLPPD-PIFASAMSENDNVFCA----QLQCFHFPTLRHHDLHSWHAESCSEKS 260

  Fly   490 EFDCGGGLCIPNAKVCNRRKD---------CPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGY 545
            .|.|      ..::.|...||         .|.|:|                    .|::     
Mouse   261 SFLC------KRSQTCVDIKDNVVDEGFYFTPKGDD--------------------PCLS----- 294

  Fly   546 RCECHDGYKLGADQHTCVDIDECETPGICSQ-----------VCVNEIGAFKCECEAGYMRLLKN 599
             |.||.|     :...|| ...||.|..|.|           :|::..|:...:..|..|||:  
Mouse   295 -CTCHRG-----EPEMCV-AALCERPQGCQQYRKDPKECCKFMCLDPDGSSLFDSMASGMRLV-- 350

  Fly   600 HTRCKASEGHASLLLARRHDIRKIALDRPE 629
             ..|.:|....||||...|.:|:...:|.|
Mouse   351 -VSCISSFLILSLLLFMVHRLRQRRRERIE 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566
LDLa 235..267 CDD:197566
LDLa 277..313 CDD:238060 19/35 (54%)
LDLa 356..388 CDD:197566 9/39 (23%)
LDLa 400..432 CDD:197566 8/34 (24%)
LDLa 442..476 CDD:238060 7/35 (20%)
LDLa 484..517 CDD:197566 8/41 (20%)
FXa_inhibition 527..562 CDD:291342 5/34 (15%)
EGF_CA 564..594 CDD:214542 8/40 (20%)
LY 675..715 CDD:214531
LY 717..760 CDD:214531
LY 763..803 CDD:214531
FXa_inhibition 877..918 CDD:291342
Dgcr2NP_034178.2 LDLa 30..66 CDD:238060 19/35 (54%)
CLECT_DGCR2_like 114..266 CDD:153069 37/170 (22%)
VWC 270..328 CDD:214564 18/89 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..549
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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