Protein Alignment LpR2 and LRP1

DIOPT Version :10

• Sequence 1: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Sequence 2: XP_320185.5
• Gene: LRP1 / 1280340
• VectorBaseID: AGAMI1_005394
• Length: 4869
• Species: Anopheles gambiae
• Alignment Length: 1066
• Identity: 319/1066 - (29%)
• Similarity: 462/1066 - (43%)
• Gaps: 231/1066 - (21%)

  Fly   164 VLNG--NPLKFLNVSGKIGTPLD-----------ISLGLSNYCDEKQFQCSTGECIPIRFVCDGS 215
            |:||  ..:..::.:||:.....           |...:|| |...:|.|:.|.|||....|||.
Mosquito  2649 VMNGFCEDVCLIDAAGKVECHCTQGVLAADGQRCIPKSVSN-CSSSEFSCTNGNCIPFHLTCDGV 2712

  Fly   216 SDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRR---------------------------- 252
            .:|.|.|||.:..|  ....|....|||.|.:|||:.
Mosquito  2713 KNCLDGSDELVTFC--AHRPCPDGFFRCNNARCIPKNQQCNHIQNCGDGSDEVGCSCNNATHFRC 2775

  Fly   253 --------------------------------------------------WVCDRENDCADGSDE 267
                                                              |.||.||||.|.|||
Mosquito  2776 TDGQCIVKSMRCDYEPDCKDVSDEIGCPVMRNCTEGFVNCANTTGCYMPTWRCDGENDCWDNSDE 2840

  Fly   268 STSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRD------GSDEAQCNRTCRSDEFTCGN 326
            ........||..::|.|  ..|.|||.||.||...||.|      .|||..|.:.|:.::|.|.|
Mosquito  2841 QDCPTAIPTCPEDKFLC--ANGRCIPQSWRCDDEDDCTDATGGGLSSDELACVKHCKPNQFKCTN 2903

  Fly   327 -GRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFAC-KSGPCIPNQWVCDGDSDCRNGEDEM 389
             ..||.|.::||...||.|||||.:...:..|....|.| .:..|||.:|||||:.||...:|:.
Mosquito  2904 TSECISNSWQCDGHPDCADGSDEGDHCSRRDCPETEFQCPTTNRCIPQKWVCDGEVDCGATQDDE 2968

  Fly   390 QNCTVSLLNFCQAGEFQC--SDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCR--------- 443
            ..|...::|.|....|.|  .:.|:.||   |||||.||.||.||      .:.|:
Mosquito  2969 MGCDEMMVNECDKTSFTCKNGECISLLH---VCDGEQDCVDGSDE------PLYCKEGDDGYDEE 3024

  Fly   444 ------------PDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATT------- 489
                        ||.|:||:..||..:||||...||||||||   ||    |.|..||
Mosquito  3025 EGAGVDDHLCVEPDHFRCNNGRCIERNLTCNVNDDCADGSDE---DI----RLCRNTTLICAGPD 3082

  Fly   490 EFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYK 554
            .|.|..|.||.:..:|:...||.:..||.:  |.:|||......|.|:|.:..|||.|.|..|::
Mosquito  3083 LFRCESGACITSNMLCDGANDCGDWSDEKS--CQVNECEMIPDLCAHECEDRPVGYECVCRKGFR 3145

  Fly   555 LGA-DQHTCVDIDEC--ETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGH---ASLL 613
            :.. |:|.|||:|||  :.|..|:|.|||..|::.|.|..|:  :|:::..|:|...|   ..|:
Mosquito  3146 VNVNDKHLCVDVDECTEQQPRPCTQTCVNTHGSYHCTCLDGF--VLRDNDTCRAEGRHILPPKLI 3208

  Fly   614 LARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVA-TQSIYKAPIDEGND-RTV- 675
            .:.|:.:|::.|. ..||.:.::...|..|||.::....:||||. |.:..|...:.|.: |.|
Mosquito  3209 FSNRYYLREVDLS-GGMTILAHNLTNAITLDFDWKDECYYWSDVTRTVTTVKRMCESGEENRPVE 3272

  Fly   676 VLTKSSVTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 739
            |:.::::.: :||||||:..::|:.|....|||::..:|...:||:...|..||:|||||...:|
Mosquito  3273 VIHRTNLKNPEGLAVDWVGRNLYWCDKGLDTIEVSKLDGRYRRVLINKELQKPRAIALDPYRRYM 3337

  Fly   740 YWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRH 804
            ||:|||..|.|.||||||:::|.:|...:.|||.:|:.....:|:|.|.:.:.|:.|:.|| |..
Mosquito  3338 YWTDWGDQPHIGRAGMDGSNQTILIKEQLGWPNALTISFETNQLFWGDAREDYIAVSDLDG-QNV 3401

  Fly   805 QVLYSGE-----YLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHV 864
            ::|.|..     .|.|.|:|..:||.:||:|.|.:::...:||.|....  |..:.:..||.:.|
Mosquito  3402 RILLSRARQPTLNLHHVFAIAVWEDRIYWSDLDSKSIEYCHKFRGDGCG--TLINTIHRPMDIRV 3464

  Fly   865 YHPYR--QPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLGIP-- 925
            :|.||  ||: ||.|.:..  |..||:.:|    ..|...|.||....|..||..|..:....
Mosquito  3465 FHYYRQLQPE-VNPCDTAG--CQTLCVLSP----DPPGYRCLCPDNFILTADGKSCAANCSAAHF 3522

  Fly   926 ---TVRPTAPMHRTIEQSSNSTTKLPQDGYSETP----VETKTG-----NNRTDTSNQV-----H 973
               |.....|.:...::..:.     .||..|.|    ...:.|     |.|....:|:     .
Mosquito  3523 QCRTTFKCIPFYWRCDKQDDC-----GDGSDEPPNCPTFTCEAGQFQCLNKRCINPSQICDGVDQ 3582

  Fly   974 KSDAESEND---------YVEIALHVIASLAGTALVASVIYVVYRRCTRAVNSMNFENPVYHKTT 1029
            ..|...|.|         :.:.......:.:|..:..:      |||...||..|         .
Mosquito  3583 CGDLSDERDCDRFECFSSHFKCGPSAAKNTSGFCIEGA------RRCDEEVNCPN---------G 3632

  Fly  1030 EDHFSLE-KNGTPHIYAAANDEEAVN 1054
            ||..:.| ||.|...:..||....::
Mosquito  3633 EDEQNCEPKNCTATQFRCANGGRCID 3658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	13/30 (43%)
		LDLa	235..267	CDD:197566	17/109 (16%)
		LDLa	277..313	CDD:238060	17/41 (41%)
		LDLa	356..388	CDD:197566	13/32 (41%)
		LDLa	400..432	CDD:197566	15/33 (45%)
		LDLa	442..476	CDD:238060	20/54 (37%)
		LDLa	484..517	CDD:197566	11/39 (28%)
		FXa_inhibition	527..562	CDD:464251	12/35 (34%)
		EGF_CA	564..594	CDD:214542	14/31 (45%)
		LY	675..715	CDD:214531	14/41 (34%)
		LY	717..760	CDD:214531	24/42 (57%)
		LY	763..803	CDD:214531	12/39 (31%)
		Ldl_recept_b	782..828	CDD:459654	16/50 (32%)
		Ldl_recept_b	824..866	CDD:459654	12/41 (29%)
		FXa_inhibition	877..918	CDD:464251	12/40 (30%)
LRP1	XP_320185.5	None