DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and lrp2b

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:XP_021335953.1 Gene:lrp2b / 101886177 ZFINID:ZDB-GENE-111115-1 Length:4577 Species:Danio rerio


Alignment Length:930 Identity:331/930 - (35%)
Similarity:465/930 - (50%) Gaps:99/930 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 FGSSINSVLNGNPLKF---LNVSGKI-GTPLDISLGLS--------------NYCDEKQFQCSTG 203
            |.|..|.:.||....|   ...|.:: |.|..:.|..:              :.|.:..|.|..|
Zfish   941 FKSRCNMIPNGRCSHFCFPTPASSRVCGCPFGMKLQENQRDCVKDDSEPPPDDNCGDYAFPCDGG 1005

  Fly   204 ECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDES 268
            .|:|..:.|||.:||.|.:||  ..|....:|||...|.|||..|||.||.||..:||.|||||:
Zfish  1006 RCVPNTYRCDGVNDCVDKTDE--VNCTLPGATCSPYAFTCGNKHCIPARWRCDGHDDCGDGSDET 1068

  Fly   269 TSQCRS-HTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCN---RTCRSDEFTCGNGRC 329
            ....|. .|||..:|||.:  |.|||.:|:||...||.|||||..||   .||:...|.|.:.||
Zfish  1069 NCPTRGPTTCSSSQFACTN--GNCIPKTWVCDAFNDCGDGSDERHCNSSITTCQPGFFLCPDHRC 1131

  Fly   330 IQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACKSG-PCIPNQWVCDGDSDCRNGEDEMQNCT 393
            |.|.:.||.|.||.||||||:|  ...||:..|||.|| .|:...:.|||..||::..|| ..|.
Zfish  1132 IYNSYVCDGDQDCLDGSDEKDC--VYTCGTYEFACASGDQCVSQSYRCDGVYDCKDHSDE-SGCP 1193

  Fly   394 VSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGH 458
            ......|...||||.....|:.|.|.|||..||.||.|| .:.|...:|...||||.:.:|::.:
Zfish  1194 TRRPGLCHDNEFQCQVDGFCIPKEWECDGHPDCVDGSDE-HNGCPPRTCSSVQFQCANGNCVSKN 1257

  Fly   459 LTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGG--------LCIPNAKVCNRRKDCPNGE 515
            ..|:|:.||.|.|||..|          .|..|.|..|        :||.||:||:.::|||||.
Zfish  1258 WVCDGENDCRDMSDETNC----------PTPPFSCPSGQWLCPTDQVCIMNAQVCDGQRDCPNGA 1312

  Fly   516 DEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQVCVN 580
            || :..|..::|...||||.|.|:....|.:|.|..|::|..|..||.||:||..||.|||.|.|
Zfish  1313 DE-SPICNEDDCKVNNGGCSHGCIQGPFGAQCTCDPGFQLLNDSKTCDDINECLIPGFCSQTCFN 1376

  Fly   581 EIGAFKCECEAGYMRLLKNHTRCKA-SEGHASLLLARRHDI--RKIALDRPEMTSIVNSTKAATA 642
            |.|:|:|.||.|| :|..:...|:| |.|:|.||:|||..|  .:|....|.::.|| |..:..|
Zfish  1377 ERGSFRCYCEDGY-QLEPDGRTCRATSPGNALLLVARRSQIIGNRINFWPPIISPIV-SGMSIVA 1439

  Fly   643 LDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIE 707
            :||......::|.|.:.:.||.: ...|.|:..|.:...:..:.:||||:..::|:||:....||
Zfish  1440 VDFDNVNKRVYWGDSSDKMIYSS-FQNGTDKKQVFSSGLMVPESIAVDWVGRNIYWTDSVMQNIE 1503

  Fly   708 LTNFEGSMGKVLVKDSLDIPRSIALDPIE--GWMYWSDWGASPRIERAGMDGTHRTAIITYDVKW 770
            :...:|...|:|:..::..||.:.|||..  ..|:|||||.:||||:|.|||..|.||:|..|.|
Zfish  1504 VATLDGHFRKILITKNVTSPRGLVLDPRNHTNLMFWSDWGQNPRIEQASMDGLGRRAIVTSKVYW 1568

  Fly   771 PNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQA 835
            |||:|||...:|:|:||..|..|...:|||..||||..|...|:.|..||.|||.::|:|.....
Zfish  1569 PNGLTLDYTTRRVYFVDAYLKYIDYCDYDGKNRHQVFASDIVLQQPHGITIFEDNIFWSDSYTSQ 1633

  Fly   836 VFKANKFNGMDVEP-VTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSP 899
            :.:.|||:|.::.. :|..:..   |.:.:.||.:||...|.|:  |..||.|||    ::...|
Zfish  1634 IMRTNKFHGGNITTLLTGVYQC---MGIVMDHPIKQPIAFNPCE--NNPCSQLCL----LSTLRP 1689

  Fly   900 R-ISCACPTGLKLMPDGLMCVEDLG--IPTVRPTAPMHRTIEQSSNSTTKLPQDGYSETPVETKT 961
            | ..|.|.:|..|..||..|.:|..  :..||.|..|...:..:..|...:       .|:...|
Zfish  1690 RYYRCDCQSGWILASDGRTCTKDETPFLMVVRDTVIMGIPLNPNDTSNNAM-------APISGIT 1747

  Fly   962 GNNRTDTSNQVH--------------KSDAESENDYVEIALHVIASLAGTAL--VASVIYVVYRR 1010
            .....|..::..              |:|..:...:...|  :|.|.:|.|.  :..::|  |..
Zfish  1748 QGRDIDFDDREQFVYWVQGTGAIYRSKTDGANRTQFAPAA--IIGSPSGLAFDWITRIMY--YTN 1808

  Fly  1011 CT-RAVNSMNFENPVYHKTT 1029
            .| :|:..:..:...:::.|
Zfish  1809 PTIKAIEVIRVDGSQHYRKT 1828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 12/30 (40%)
LDLa 235..267 CDD:197566 19/31 (61%)
LDLa 277..313 CDD:238060 19/35 (54%)
LDLa 356..388 CDD:197566 13/32 (41%)
LDLa 400..432 CDD:197566 15/31 (48%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 484..517 CDD:197566 15/40 (38%)
FXa_inhibition 527..562 CDD:291342 13/34 (38%)
EGF_CA 564..594 CDD:214542 18/29 (62%)
LY 675..715 CDD:214531 11/39 (28%)
LY 717..760 CDD:214531 21/44 (48%)
LY 763..803 CDD:214531 19/39 (49%)
FXa_inhibition 877..918 CDD:291342 15/41 (37%)
lrp2bXP_021335953.1 LDLa 2..34 CDD:238060
LDLa 38..71 CDD:197566
LDLa 80..114 CDD:238060
LDLa 123..151 CDD:238060
LDLa 155..189 CDD:238060
LDLa 194..228 CDD:238060
LDLa 235..269 CDD:238060
FXa_inhibition 324..>347 CDD:317114
LY 429..469 CDD:214531
LY 471..516 CDD:214531
LY 519..559 CDD:214531
FXa_inhibition 631..672 CDD:317114
Ldl_recept_b 808..848 CDD:278487
LY 834..874 CDD:214531
FXa_inhibition 950..982 CDD:317114 7/31 (23%)
LDLa 995..1029 CDD:238060 14/35 (40%)
LDLa 1036..1070 CDD:238060 20/33 (61%)
LDLa 1078..1112 CDD:238060 19/35 (54%)
LDLa 1119..1153 CDD:238060 18/33 (55%)
LDLa 1157..1192 CDD:238060 15/35 (43%)
LDLa 1200..1234 CDD:238060 17/34 (50%)
LDLa 1241..1275 CDD:238060 14/33 (42%)
LDLa 1282..1314 CDD:197566 13/31 (42%)
FXa_inhibition 1323..1358 CDD:317114 13/34 (38%)
EGF_CA 1360..1398 CDD:214542 20/38 (53%)
YncE 1388..>1660 CDD:331368 101/277 (36%)
LY 1470..1512 CDD:214531 11/41 (27%)
Ldl_recept_b 1535..1575 CDD:278487 24/39 (62%)
LY 1559..1601 CDD:214531 20/41 (49%)
LY 1789..1824 CDD:214531 8/36 (22%)
LY 1837..1879 CDD:214531
LY 1922..1958 CDD:214531
FXa_inhibition 1991..2027 CDD:317114
Ldl_recept_b 2170..2210 CDD:278487
LY 2195..2236 CDD:214531
LY 2427..2468 CDD:214531
LY 2468..2510 CDD:214531
LY 2513..2553 CDD:214531
FXa_inhibition 2623..2660 CDD:317114
LDLa 2667..2699 CDD:197566
LDLa 2709..2743 CDD:238060
LDLa 2750..2785 CDD:238060
LDLa 2789..2822 CDD:197566
LDLa 2831..2863 CDD:197566
LDLa 2873..2905 CDD:197566
LDLa 2915..2952 CDD:197566
LDLa 2961..2995 CDD:238060
LDLa 2999..3031 CDD:197566
Ldl_recept_a 3042..3077 CDD:278486
cEGF 3100..3123 CDD:315355
vWFA <3115..3158 CDD:320736
LY 3189..3229 CDD:214531
LY 3230..3272 CDD:214531
Ldl_recept_b 3303..3341 CDD:278487
LY 3327..3367 CDD:214531
LY 3374..3409 CDD:214531
LDLa 3480..3512 CDD:197566
LDLa 3521..3552 CDD:197566
LDLa 3561..3593 CDD:197566
LDLa 3602..3634 CDD:197566
LDLa 3646..3682 CDD:238060
LDLa 3689..3722 CDD:238060
LDLa 3727..3761 CDD:238060
LDLa 3766..3800 CDD:238060
LDLa 3810..3841 CDD:197566
LDLa 3854..3883 CDD:197566
LDLa 3896..3930 CDD:238060
EGF_CA 3975..4014 CDD:214542
LY 4107..4142 CDD:214531
LY 4143..4186 CDD:214531
LY 4187..4230 CDD:214531
FXa_inhibition 4306..>4324 CDD:317114
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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