DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR2 and Gm19410

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_006509297.1	Gene:	Gm19410 / 100502846	MGIID:	5011595	Length:	2104	Species:	Mus musculus

Alignment Length:	863	Identity:	277/863 - (32%)
Similarity:	397/863 - (46%)	Gaps:	113/863 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 CSQEQFRCGNGK-CIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCD 299
            |::....|.:|| ||||..:|:.|.||.|||||  ..|......|..|.|..| ..||...:.||
Mouse   871 CARSSVPCQDGKGCIPRESLCNGEADCQDGSDE--KNCSQICHQPGVFQCLDG-SRCIEERYHCD 932

  Fly   300 QNKDCRDGSDEAQCNRTCRSDEFTCGN-GRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFA 363
            ..:.|.|||||..|.|........|.| .|||...::||...||.|..||:.|..: ||.|..|.
Mouse   933 GAQHCSDGSDELDCWRPADDCSMHCDNKTRCIPKSWRCDGKPDCLDRRDEQGCFHE-KCSSPEFQ 996

  Fly   364 CKSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPD 428
            |::|.||.:...||||.||.:..|| :.|.|:....|..||.:|.....|:...|:||.:.||.|
Mouse   997 CENGQCISSSLRCDGDRDCLDHSDE-EGCPVAWSLQCPEGEMKCPKSGECVLAEWICDHDVDCKD 1060

  Fly   429 GEDESQSNCLKVSCRPDQFQCN--DQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEF 491
            |.||.......:||.|.|:.|:  || |:.....|:|:.||.|||||..|    .|:.|. .:||
Mouse  1061 GTDEKDCGLKVISCGPRQWACDSGDQ-CVPDFWHCDGQSDCRDGSDEAGC----APQKCQ-DSEF 1119

  Fly   492 DCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLG 556
            .|..|.|:..:.||:.|:||.:|.|| .|:|..:.||.  |.|.|.|.....|..|.|..|::|.
Mouse  1120 QCATGACLSFSMVCDGREDCVDGSDE-GGECSSSVCSP--GLCYHSCYQSPTGPVCVCAPGFELE 1181

  Fly   557 ADQHTCVDIDECETPG--ICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHD 619
            ::...|.|::||:.|.  .|||.|:|..|::.|.|..||:.....|| |||:.....||::...:
Mouse  1182 SNGQICQDVNECQQPSGQPCSQTCINTEGSYICACHPGYLLGPDGHT-CKATGAEPILLVSIEFN 1245

  Fly   620 IRKIALD--RPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSV 682
            :....|.  :.::.:..:...|..::|:......|||:|...:||....:....|..||   ..:
Mouse  1246 LFLSGLRSLKEDILTTADKNLAIYSVDYDLVDQKIFWADPNAESIRWTSMATKKDGIVV---QGI 1307

  Fly   683 TSDGLAVDWIYNHVYFTDTHK---CTIELTNFEGSMGK------VLVKDSLDIPRSIALDPIEGW 738
            ..|.:.||||..::|:||...   ..|:||    :||:      |::.|.|..|:|:||||:.|.
Mouse  1308 KPDCIGVDWIGRNLYWTDGRAGQILAIQLT----AMGRGKSEYTVVLDDDLIRPQSLALDPLNGL 1368

  Fly   739 MYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGS-- 801
            ||||:.|..||||:|||||:.|..::...:..|..|.||.:..:::|.|.|.:.|.|.|.|||
Mouse  1369 MYWSETGEEPRIEQAGMDGSSRKILVNQGLGHPTSIALDQLSWKIFWSDEKFHCIGSVNLDGSGI 1433

  Fly   802 ---QRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVH 863
               |..|:       :.|||:..|||.|:|:|...:.:..|.|..|.|  ..........|..:.
Mouse  1434 SMMQLTQI-------KSPFSVAVFEDKVFWSDLQTRTIQHAEKMTGKD--RAVLIKRSGQPFGLK 1489

  Fly   864 VYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLGIPTVR 928
            :.|...||...:.|..:.  ||||||.:||     .:.||.||.||.|..||:.||
Mouse  1490 IMHEVLQPRSSSPCLDIG--CSHLCLLSPR-----AKGSCRCPVGLLLADDGITCV--------- 1538

  Fly   929 PTAPMHRTIEQSSNSTTKLPQDGYSETPVETKTGNNRTDTSNQVHKSDAESENDYVEIALHVIAS 993
                   ::::|......||       .|.|:.......||.|            ..:..|.|..
Mouse  1539 -------SLQESGFVFLVLP-------TVLTQIYLKNLKTSQQ------------TTVPEHRILP 1577

  Fly   994 LAGTALVASVIYVVYRRC-------TRAVNSMNFENP--------VYHKTTEDHFSLE-KNGTPH 1042
            ......:|||.|:|..:.       |..:..:..:.|        :..|.|...|:|: .:|  :
Mouse  1578 FTSVKQLASVDYLVQEKALYLSELNTSDIRLLRMKEPGILSWRRVISVKGTVIDFALDWMSG--N 1640

  Fly  1043 IYAAANDEEAVNPLFKSG 1060
            ||....|...:|..|.:|
Mouse  1641 IYWIDTDNPYINVAFSNG 1658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566	15/31 (48%)
		LDLa	277..313	CDD:238060	14/35 (40%)
		LDLa	356..388	CDD:197566	14/31 (45%)
		LDLa	400..432	CDD:197566	12/31 (39%)
		LDLa	442..476	CDD:238060	16/35 (46%)
		LDLa	484..517	CDD:197566	12/32 (38%)
		FXa_inhibition	527..562	CDD:291342	11/34 (32%)
		EGF_CA	564..594	CDD:214542	13/31 (42%)
		LY	675..715	CDD:214531	13/42 (31%)
		LY	717..760	CDD:214531	24/48 (50%)
		LY	763..803	CDD:214531	13/44 (30%)
		FXa_inhibition	877..918	CDD:291342	18/40 (45%)
Gm19410	XP_006509297.1	LDLa	<42..63	CDD:238060
		LDLa	75..104	CDD:238060
		LDLa	150..184	CDD:238060
		LDLa	187..218	CDD:197566
		FXa_inhibition	226..261	CDD:373209
		EGF_CA	263..301	CDD:214542
		LY	409..454	CDD:214531
		LY	<465..497	CDD:214531
		LDLa	871..906	CDD:238060	17/36 (47%)
		LDLa	912..946	CDD:238060	14/34 (41%)
		LDLa	956..985	CDD:238060	12/28 (43%)
		LDLa	990..1024	CDD:238060	15/34 (44%)
		LDLa	1032..1067	CDD:238060	14/34 (41%)
		LDLa	1074..1109	CDD:238060	16/35 (46%)
		LDLa	1114..1145	CDD:238060	12/31 (39%)
		FXa_inhibition	1201..1229	CDD:373209	12/28 (43%)
		LY	1302..1341	CDD:214531	14/45 (31%)
		Ldl_recept_b	1367..1407	CDD:278487	18/39 (46%)
		LY	1391..1432	CDD:214531	12/40 (30%)
		FXa_inhibition	1507..1537	CDD:373209	17/36 (47%)
		LY	1620..1658	CDD:214531	10/39 (26%)
		YvrE	<1693..>1763	CDD:225921
		FXa_inhibition	1822..1856	CDD:373209
		LDLa	1869..1897	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910