DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and lrp3

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_009301583.1	Gene:	lrp3 / 100170796	ZFINID:	ZDB-GENE-080116-3	Length:	824	Species:	Danio rerio

Alignment Length:	342	Identity:	95/342 - (27%)
Similarity:	130/342 - (38%)	Gaps:	109/342 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 ESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDEST-----SQCRSHTCSPEEFACKSGEG-EC 291
            :|:|.::::.||||||:||.|.|:..::|.|.:||..     :..|:..|.|....|...:. .|
Zfish   148 QSSCEKDEYLCGNGKCVPRSWRCNGLDECGDNTDERNCVAPPTPARASLCPPGTLQCSDVQSTRC 212

  Fly   292 IPLSWMCDQNKDCRDGSDEAQCNRTCRSDEFTCGNGRCIQ--NRFKCDD----------DDDCG- 343
            :|.|..|:..:||.||||||:|..|      :||. |.:.  ..|...|          |..|.
Zfish   213 LPGSLRCNGARDCPDGSDEARCPDT------SCGK-RLVNFYGTFASPDFFRPNRSTGTDLHCTW 270

  Fly   344 --DGSDEK--------------------NCGEKAK----------------------CGSNFFAC 364
              |..|.|                    ..||:|:                      ..|.|:..
Zfish   271 FLDTKDPKPLVLQVDLQLGVGDSVRVYDGLGEQAERLLQSLSHHNNHRRALLESSQGQMSIFYHA 335

  Fly   365 K--------------SGPCIPNQWV-------------CDGDSDCRNGEDEMQNCTVSLLNFCQA 402
            |              .|.|.|.:..             |||...|..|.|| :.|.:     ||.
Zfish   336 KPHSPGHGFNATYQVKGYCFPGEHPCGTDEGCYSDLQRCDGYWHCPGGRDE-EACPL-----CQP 394

  Fly   403 GEFQCSDRI-TCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRD 466
            ||:.|.... .|...|..|:.:..||||.||  .||.  .|:|..|.|....||.....|:|:.|
Zfish   395 GEYPCEGGSGACYSASERCNNQKKCPDGSDE--KNCF--DCQPGNFHCGTNLCIFETWRCDGQED 455

  Fly   467 CADGSDEIMCDISATPR 483
            |.|||||..| :::.||
Zfish   456 CMDGSDERDC-LASVPR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566	13/31 (42%)
		LDLa	277..313	CDD:238060	15/36 (42%)
		LDLa	356..388	CDD:197566	11/80 (14%)
		LDLa	400..432	CDD:197566	12/32 (38%)
		LDLa	442..476	CDD:238060	15/33 (45%)
		LDLa	484..517	CDD:197566	95/342 (28%)
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531
		LY	717..760	CDD:214531
		LY	763..803	CDD:214531
		FXa_inhibition	877..918	CDD:291342
lrp3	XP_009301583.1	CUB	31..141	CDD:238001
		LDLa	151..185	CDD:238060	15/33 (45%)
		LDLa	197..234	CDD:238060	15/36 (42%)
		CUB	239..350	CDD:238001	16/111 (14%)
		LDLa	354..389	CDD:238060	9/35 (26%)
		LDLa	392..428	CDD:238060	14/37 (38%)
		LDLa	431..465	CDD:238060	15/33 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900