DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5028 and idhg-1

DIOPT Version :9

Sequence 1:	NP_001097922.1	Gene:	CG5028 / 43102	FlyBaseID:	FBgn0039358	Length:	402	Species:	Drosophila melanogaster
Sequence 2:	NP_497927.2	Gene:	idhg-1 / 175598	WormBaseID:	WBGene00009440	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	193/380 - (50%)
Similarity:	270/380 - (71%)	Gaps:	26/380 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VAHT----KSALQKKVTGTDIPS-----------------AQYGGRHAVTMLPGGGIGPELMGYV 76
            :.||    |:.:||....|...|                 |:|||||.||:|||.|||||::.:|
Worm     6 LGHTLRSSKNVVQKAFVATSPNSDMLRFRSPVLQTNTTKLARYGGRHNVTVLPGDGIGPEMLHHV 70

  Fly    77 REIFRYCGAPIDFEVIDIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNE 141
            ..|.....||:||||:::....:.::||..|||:|||||||||||||||..:.:.||||:.:|.:
Worm    71 ERILSAVQAPVDFEVVNLTSKEDASEDLAEAITAIKRNGVALKGNIETKFDNPSFVSRNLELRRQ 135

  Fly   142 LDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESV----PGIVESMKVVTVENAER 202
            |:||.||:||.:.|.:|:||..||:|:||:||:|||:..|||:|    |.:|||:||||.|.:|:
Worm   136 LNLYANVLHCSTIPTVPSRHTGIDMVIIRENTEGEYSGNEHEAVNAPHPRVVESLKVVTREKSEQ 200

  Fly   203 VARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHK-DYPELEHNNMIIDNTCMQSVSN 266
            :.|:||:||::..|||||.:|||||.||.|||||:||..:.| :||::|.|.||:||..||.||.
Worm   201 ITRFAFQFAKKYGRKKVTAVHKANIQKLGDGLFLKVATDIAKAEYPDIEFNAMIVDNASMQLVSR 265

  Fly   267 PHQFDVMNMTNLYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAM 331
            |.|||||.|.||||.|:||:.|||:||.||:||.|.|:.||:||.|||||||.:|||::|||.|.
Worm   266 PQQFDVMLMPNLYGNIISNIACGLVGGPGLVSGMNIGEDYAVFETGTRNTGTTLAGKDLANPTAF 330

  Fly   332 ISASIDMLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTNSSTDVVENILKIL 386
            |.|::|||..||.:.||::|.:::::|:|:..|.|.|||||:.|:::|:::|..:
Worm   331 IRAAVDMLRFLGLQSHADMISDSLFRTLVDKRIHTADIGGTSKSSELVQSVLDFI 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5028	NP_001097922.1	mito_nad_idh	55..386	CDD:272942	184/335 (55%)
idhg-1	NP_497927.2	Iso_dh	49..383	CDD:294303	183/333 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167072
Domainoid	1	1.000	380	1.000	Domainoid score	I447
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55803
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1090
Isobase	1	0.950	-	0	Normalized mean entropy	S556
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		otm14597
orthoMCL	1	0.900	-	-		OOG6_101342
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X402
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.760