DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4730 and MTF-1

DIOPT Version :9

Sequence 1:	NP_001262965.1	Gene:	CG4730 / 43099	FlyBaseID:	FBgn0039355	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	89/361 - (24%)
Similarity:	144/361 - (39%)	Gaps:	69/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FTIARRTAEAPVKLV-------------SHE-----VSLSDSTTSL-ELSNCCRLCLEEPYPNQM 59
            |::|.:....|:.::             ||.     .||||.|..: .|.:.| ..||..:.||.
  Fly   153 FSLADQLTPLPITVIPITYHHTTENLSSSHSEVPLIASLSDITAQVFNLDDIC-FTLEYQFENQR 216

  Fly    60 L----DMTVI------YDQEAALSYYDC-YEICTKEDL-RQNPKNEPRTLCKRCAVELKWAYDFH 112
            |    ..||:      ...|||....:| .:..|...: |.:..|.|...    .:|..:..::.
  Fly   217 LVQVQPPTVVSLSMVSSPNEAANPPINCDNDQGTGNSISRDSTSNSPAYF----TIETSYVDEYD 277

  Fly   113 KKMAIANQQLREIFVATEANTEQEDDVEDEENEADMNEEFLMEEIEEKQE--------------- 162
            ......::||..   ..:.....:|..|:|....|.|::.:....|...|
  Fly   278 PNEPDEDEQLAH---CIQPGVLHQDVDEEEVERQDENDQLMALAYESSDEALSRYRCNYENCYRS 339

  Fly   163 -TPIDSLEDIVPRNRHTGKSNCKF----CHKEFRNHSRMAKHQMIHLANRPNFRC--SQCDRVYL 220
             :.|.:|...:  ..|||..:.|.    |||.|.....:..|..:|...:| :.|  |.||:.:.
  Fly   340 YSTIGNLRTHL--KTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKP-YECEVSGCDKAFN 401

  Fly   221 TKQALKVHVDSKHRQSGVHCDTCGKVFAIAKALEIHKRYHNRDFPYSC--DLCDRRFAQRSHLTV 283
            |:..|..|: ..|.....:|:.|.|.|.....|:.|.|.|.::.||.|  |.|.:.|....||..
  Fly   402 TRYRLHAHL-RLHNGETFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKT 465

  Fly   284 HQQVKHSGSR-FICEFPGCQKSFTSSSSLRNHECTH 318
            |::. |:|.: :.|:...|||||::|.||::|:.||
  Fly   466 HRRT-HTGEKPYPCQEDSCQKSFSTSHSLKSHKKTH 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4730	NP_001262965.1	zf-AD	46..124	CDD:285071	19/89 (21%)
		C2H2 Zn finger	183..203	CDD:275368	6/23 (26%)
		C2H2 Zn finger	212..232	CDD:275368	7/21 (33%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..289	CDD:275368	7/22 (32%)
		C2H2 Zn finger	296..318	CDD:275368	10/21 (48%)
		C2H2 Zn finger	325..346	CDD:275368
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	38/146 (26%)
		C2H2 Zn finger	331..353	CDD:275368	2/23 (9%)
		zf-H2C2_2	345..372	CDD:290200	9/28 (32%)
		C2H2 Zn finger	361..383	CDD:275368	5/21 (24%)
		zf-H2C2_2	375..402	CDD:290200	7/27 (26%)
		C2H2 Zn finger	391..413	CDD:275368	7/22 (32%)
		zf-C2H2	418..440	CDD:278523	7/21 (33%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..458	CDD:290200	9/25 (36%)
		COG5048	442..>519	CDD:227381	23/60 (38%)
		C2H2 Zn finger	448..470	CDD:275368	7/22 (32%)
		zf-H2C2_2	462..489	CDD:290200	11/27 (41%)
		C2H2 Zn finger	478..500	CDD:275368	10/21 (48%)
		DUF3682	862..>931	CDD:289231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930