DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4730 and CG1529

DIOPT Version :9

Sequence 1:	NP_001262965.1	Gene:	CG4730 / 43099	FlyBaseID:	FBgn0039355	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	105/447 - (23%)
Similarity:	165/447 - (36%)	Gaps:	133/447 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TTSLELSNCCRLCLEE--------PYP------NQMLDMTVIYDQEAALSYYDCYEICTKEDLRQ 88
            ||..:|:..||:||..        |.|      .::||:                      |:.:
  Fly     3 TTFTDLARLCRICLRHLRDRDTHCPDPRLIAILQKLLDI----------------------DILK 45

  Fly    89 NPKNEPRTLCKRCAVELKWAYDFHKKMAIANQQL---REIFVATEANTEQEDD----VEDEENEA 146
            .|...|..:|..|...:.:..:..:....::|:|   :.:.:|.:...|:..|    ...||||.
  Fly    46 QPHGFPTEICNLCHNAVVYFDELRQVARESSQKLIGWQPVDIAVDRVKEEPPDEGLKENHEENEH 110

  Fly   147 DMNEEFLME------EIEEKQETP---IDSLED-------------------------------- 170
            ::.||...:      ::.:|||..   :|..||
  Fly   111 ELEEEHEKQADGQQVDLSKKQEDQKKILDDREDEEYPDEYENSQQQLSQGTGSKRRAGLACDQCG 175

  Fly   171 ----IVP------RNRHTGKSN---CKFCHKEF------RNHSRMAKHQMIHLANR-PNFRCSQC 215
                .:|      |:.|.|.|.   |:.|.|.|      |:|.|.|..|:..|... .:..|..|
  Fly   176 KQVYKLPYLEAHIRSVHQGYSKPFLCRSCDKSFTRYEQLRSHMRNAHPQLEQLQQELRDLICELC 240

  Fly   216 DRVYLTKQALKVHVDSKHRQSGVH-CDTCGKVFAIAKALEIHKRYHNRDFP-YSCDLCDRRFAQR 278
            :|.|.||.||..|: .:|.|...| |:.||........|..|.|.||..:. :.|:.|.:.|..:
  Fly   241 NRQYSTKNALGEHL-KRHAQRKEHVCEHCGVAKVTRTELLTHLRTHNPTWERFKCEQCPQLFRHK 304

  Fly   279 SHLTVHQQVKHSGS-RFICEFPGCQKSFTSSSSLRNHECTHT----------AMPFECAHCHQSY 332
            |.::.|.:|.|.|. ||.|..  |:|.|.:.:|...||..||          ..||.|.||.:..
  Fly   305 SAISRHVRVVHEGQRRFQCGH--CEKKFGTHASQVRHERLHTESTGSGEAAEEWPFACIHCQKPC 367

  Fly   333 PARNKLRMHLERKHNMVVQMEDLEEMRKFHIVRSKLVMAKIYSDQKESHHAKNDSAA 389
            .:|..|.:|| |:|          ..||.|  |.:...::...:|::.|....:..|
  Fly   368 VSRQTLELHL-RRH----------RARKTH--RKRREHSRESQEQEQEHDRDQEQGA 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4730	NP_001262965.1	zf-AD	46..124	CDD:285071	15/94 (16%)
		C2H2 Zn finger	183..203	CDD:275368	9/25 (36%)
		C2H2 Zn finger	212..232	CDD:275368	9/19 (47%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		C2H2 Zn finger	268..289	CDD:275368	6/20 (30%)
		C2H2 Zn finger	296..318	CDD:275368	7/21 (33%)
		C2H2 Zn finger	325..346	CDD:275368	8/20 (40%)
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071	14/89 (16%)
		C2H2 Zn finger	171..192	CDD:275368	2/20 (10%)
		zf-C2H2_2	201..>257	CDD:289522	19/56 (34%)
		C2H2 Zn finger	201..222	CDD:275368	7/20 (35%)
		C2H2 Zn finger	237..257	CDD:275368	9/20 (45%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		zf-C2H2_8	268..349	CDD:292531	26/82 (32%)
		C2H2 Zn finger	294..315	CDD:275368	6/20 (30%)
		C2H2 Zn finger	323..343	CDD:275368	7/21 (33%)
		C2H2 Zn finger	360..380	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930