DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4730 and ZNF362

DIOPT Version :9

Sequence 1:	NP_001262965.1	Gene:	CG4730 / 43099	FlyBaseID:	FBgn0039355	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001357141.1	Gene:	ZNF362 / 149076	HGNCID:	18079	Length:	420	Species:	Homo sapiens

Alignment Length:	195	Identity:	62/195 - (31%)
Similarity:	97/195 - (49%)	Gaps:	22/195 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 FRCSQCDRVYLTKQALKVHVDSKHRQSGVH-CDTCGKVFAIAKALEIHKRYHNRDFPYSCDLCDR 273
            :||..|...:.||..:::|..| |.::..| |..|.|.||.|..|..|.|.|....||.|..||:
Human   227 YRCKVCPLTFFTKSEMQIHSKS-HTEAKPHKCPHCSKSFANASYLAQHLRIHLGVKPYHCSYCDK 290

  Fly   274 RFAQRSHLTVHQQVKHSGSR-FICEFPGCQKSFTSSSSLRNHECTHTA-MPFECAHCHQSYPARN 336
            .|.|.|||..|.:: |:|.| :.|..|||:|:||..|:|::|:..|.. .|::|.:|:::|....
Human   291 SFRQLSHLQQHTRI-HTGDRPYKCPHPGCEKAFTQLSNLQSHQRQHNKDKPYKCPNCYRAYSDSA 354

  Fly   337 KLRMHLER---KH------NMVVQMEDLEEMRKFHIVRSKLVMAKIYSDQKESHHA--KNDSAAI 390
            .|::||..   ||      :|..:....|.....|:.:..:|      :...|||:  :.:|..|
Human   355 SLQIHLSAHAIKHAKAYCCSMCGRAYTSETYLMKHMSKHTVV------EHLVSHHSPQRTESPGI 413

Fly 391 390
Human 414 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4730	NP_001262965.1	zf-AD	46..124	CDD:285071
		C2H2 Zn finger	183..203	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368	5/19 (26%)
		C2H2 Zn finger	240..260	CDD:275368	9/19 (47%)
		C2H2 Zn finger	268..289	CDD:275368	9/20 (45%)
		C2H2 Zn finger	296..318	CDD:275368	10/21 (48%)
		C2H2 Zn finger	325..346	CDD:275368	6/23 (26%)
ZNF362	NP_001357141.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PRK14971	<27..>125	CDD:237874
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..80
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..155
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..202
		C2H2 Zn finger	229..249	CDD:275368	6/20 (30%)
		zf-H2C2_2	241..266	CDD:372612	8/25 (32%)
		zf-C2H2	255..277	CDD:333835	10/21 (48%)
		C2H2 Zn finger	257..277	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..294	CDD:372612	10/24 (42%)
		C2H2 Zn finger	285..305	CDD:275368	9/20 (45%)
		SFP1	<307..359	CDD:227516	18/51 (35%)
		C2H2 Zn finger	313..335	CDD:275368	10/21 (48%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..393	CDD:275368	3/17 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3043
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950