DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and LGR5

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_003658.1	Gene:	LGR5 / 8549	HGNCID:	4504	Length:	907	Species:	Homo sapiens

Alignment Length:	945	Identity:	199/945 - (21%)
Similarity:	330/945 - (34%)	Gaps:	305/945 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLLLAAVIFYLSLGPCPAAS----FACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKE 77
            |||...|:..|:.|.....|    ..|.....|.|..:|. .|.||:|            .|..|
Human     8 VLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRML-LRVDCSD------------LGLSE 59

  Fly    78 IAD--KIVRNAIEKKQQRLISAVSNASGADSTTSMVPRNQSL-TLNMTCDIVTY-PKACQCGQGT 138
            :..  .:..:.::.....:...:.|.         :|..:.| .|.:..:.:|| ||..
Human    60 LPSNLSVFTSYLDLSMNNISQLLPNP---------LPSLRFLEELRLAGNALTYIPKGA------ 109

  Fly   139 ILYCGRYAKLRRFPRLSSEVTNLIIIRNNLTLR---DNIFANFTRLQKLTLKYNNISRVPLGSFS 200
              :.|.|:            ..:::::|| .||   .....|...||.|.|..|:||.||...||
Human   110 --FTGLYS------------LKVLMLQNN-QLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFS 159

  Fly   201 GLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLP-----------VEQLRFFR--- 251
            ||..|..|.|..|.::.:|...|..|.:||.:.|..|.:||:|           |..|...|
Human   160 GLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHS 224

  Fly   252 ----------RLEWLVLSRNRL--------TLRNVQ-----------LPK-----IPTLYEVYLD 282
                      .||.|.|:.|.|        ||.|::           :|:     .|:|..::..
Human   225 LGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFY 289

  Fly   283 FNRIEYIGEETF-----------------------------------------------SQLDNL 300
            .|.|:::|...|                                               :||.||
Human   290 DNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354

  Fly   301 HLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLA----------- 354
            .:|||.:||:..:  .:|:....::.|.|..|.|.|:..:||.....|.:|:||
Human   355 QVLDLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNA 417

  Fly   355 ------LMPIHISSSLME--PL----NISFLNLTGIRYDHIDFEAINSMRNLTYI-------IYD 400
                  |:.:.:||:|:.  |:    .::.|.|||   :|. .:::.|..|...:       .|.
Human   418 FSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTG---NHA-LQSLISSENFPELKVIEMPYAYQ 478

  Fly   401 --RFFYCSMTPRVR-----------------------------------------------MCKP 416
              .|..|....::.                                               .|.|
Human   479 CCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSP 543

  Fly   417 STDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENV--AVTMVIRNLALADMLM 479
            |.......:.||...::|...|.:|.|.:..|.||.  ..::|....  .:.::|..:|..:||.
Human   544 SPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVT--STVFRSPLYISPIKLLIGVIAAVNMLT 606

  Fly   480 GF-YLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLI---- 539
            |. ..|..||..:.: ..:.:....|.....|.:||.|::.:||.|:.:|...:|||...:
Human   607 GVSSAVLAGVDAFTF-GSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSA 670

  Fly   540 ----ADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAF 600
                ..||...:.|       .|:|..:   .|.:|.|.|...|.   ||: |..|.||...|..
Human   671 KFETKAPFSSLKVI-------ILLCALL---ALTMAAVPLLGGSK---YGA-SPLCLPLPFGEPS 721

  Fly   601 PMGWLYSAFVFLGVNLLLLVMIAMLYTAL--------LISIWRTRSATPLTLLDCEFAVRFFFIV 657
            .||::.:..:   :|.|..:|:.:.||.|        |.:||           ||........::
Human   722 TMGYMVALIL---LNSLCFLMMTIAYTKLYCNLDKGDLENIW-----------DCSMVKHIALLL 772

  Fly   658 LTDFLCWVPIIVMKIWVFFNYN-ISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWK 721
            .|:.:...|:..:......|.. ||.::..::::.|:||.:.:|||||....|.::..:
Human   773 FTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL------ 831

  Fly   722 KITSRKRAEAGNGNVATTTTGTATGSSQHPDDFTI 756
             ::.||:          |...|   .|:||...:|
Human   832 -VSLRKQ----------TYVWT---RSKHPSLMSI 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	9/36 (25%)
		LRR_8	179..239	CDD:290566	24/59 (41%)
		leucine-rich repeat	181..204	CDD:275380	13/22 (59%)
		LRR_RI	<196..354	CDD:238064	56/252 (22%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/46 (22%)
		leucine-rich repeat	253..275	CDD:275380	10/45 (22%)
		LRR_8	274..334	CDD:290566	19/106 (18%)
		leucine-rich repeat	276..299	CDD:275380	7/69 (10%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..347	CDD:275380	7/22 (32%)
		7tm_1	447..704	CDD:278431	65/276 (24%)
LGR5	NP_003658.1	LRRNT	33..70	CDD:214470	10/49 (20%)
		leucine-rich repeat	68..91	CDD:275380	2/31 (6%)
		PLN00113	71..>426	CDD:215061	83/386 (22%)
		leucine-rich repeat	92..115	CDD:275380	7/30 (23%)
		leucine-rich repeat	116..139	CDD:275380	5/23 (22%)
		leucine-rich repeat	140..163	CDD:275380	13/22 (59%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	236..258	CDD:275380	8/21 (38%)
		leucine-rich repeat	259..282	CDD:275380	1/22 (5%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		leucine-rich repeat	307..353	CDD:275378	2/45 (4%)
		leucine-rich repeat	354..375	CDD:275378	7/22 (32%)
		leucine-rich repeat	376..389	CDD:275378	4/12 (33%)
		leucine-rich repeat	400..423	CDD:275378	4/22 (18%)
		leucine-rich repeat	445..459	CDD:275378	5/17 (29%)
		7tmA_LGR5	558..831	CDD:320485	72/303 (24%)
		TM helix 1	559..585	CDD:320485	7/27 (26%)
		TM helix 2	592..617	CDD:320485	7/24 (29%)
		TM helix 3	637..667	CDD:320485	11/29 (38%)
		TM helix 4	679..701	CDD:320485	6/31 (19%)
		TM helix 5	721..750	CDD:320485	8/31 (26%)
		TM helix 6	759..789	CDD:320485	6/40 (15%)
		TM helix 7	799..824	CDD:320485	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810