DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and SOG2

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_014998.3	Gene:	SOG2 / 854535	SGDID:	S000005880	Length:	791	Species:	Saccharomyces cerevisiae

Alignment Length:	204	Identity:	49/204 - (24%)
Similarity:	92/204 - (45%)	Gaps:	33/204 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 MVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDN 173
            ||..:...||:...:.:...|.......||:     ::|....:.||..|.|.:|..|: ::.|.
Yeast     1 MVATSSKRTLDPKEEHLPADKTSTNSSNTII-----SELATQEKSSSSGTTLKLIALNIKSISDE 60

  Fly   174 IFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNH 238
            .......:::|:|:.|:::.:| .||..|..|:.|:|.:||...:|: :......|:.|.|.:|.
Yeast    61 DVGYIQNVERLSLRKNHLTSLP-ASFKRLSRLQYLDLHNNNFKEIPY-ILTQCPQLEILDLSSNE 123

  Fly   239 LHHLPVEQLRFFR-RLEWLVLSRNRLT-LRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLH 301
            :..||.|...|:: .:..|.|..|.:| :||:                       ::.::|:.|.
Yeast   124 IEALPDEISSFWQDNIRVLSLKDNNVTSIRNL-----------------------KSITKLNKLS 165

  Fly   302 LLDLQHNLI 310
            :|||:.|.|
Yeast   166 ILDLEDNKI 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	17/59 (29%)
		leucine-rich repeat	181..204	CDD:275380	7/22 (32%)
		LRR_RI	<196..354	CDD:238064	30/117 (26%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	8/23 (35%)
		leucine-rich repeat	253..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	7/37 (19%)
		leucine-rich repeat	276..299	CDD:275380	1/22 (5%)
		leucine-rich repeat	300..323	CDD:275380	6/11 (55%)
		leucine-rich repeat	324..347	CDD:275380
		7tm_1	447..704	CDD:278431
SOG2	NP_014998.3	LRR	18..>266	CDD:227223	45/187 (24%)
		leucine-rich repeat	68..90	CDD:275378	7/22 (32%)
		leucine-rich repeat	91..113	CDD:275378	6/22 (27%)
		leucine-rich repeat	114..138	CDD:275378	8/23 (35%)
		leucine-rich repeat	139..163	CDD:275378	7/46 (15%)
		SOG2	299..781	CDD:402174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4149
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030