DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and rxfp2a

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001315313.1	Gene:	rxfp2a / 792884	ZFINID:	ZDB-GENE-040426-1225	Length:	754	Species:	Danio rerio

Alignment Length:	745	Identity:	257/745 - (34%)
Similarity:	388/745 - (52%)	Gaps:	76/745 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLIS 96
            ||...|.|.|.::|:|:...|:...||.:.:||.  .||...|..:|.|:.::.|
Zfish    42 CPLGQFPCGNMSVCLPQVLQCNGHKDCKNGADEE--HCGDNSGWADIFDRTIKKA---------- 94

  Fly    97 AVSNASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNL 161
                              :...|...|.:..||::|.| :.|.:.|.. ..|...|.|||.||.|
Zfish    95 ------------------EPQDLPNDCYLQQYPQSCSC-KKTEVECVD-VNLHVVPILSSNVTWL 139

  Fly   162 IIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLG 225
            .:..|.: .|.|.||:.:|::|:|.|:.|.|..|...:||.||.|:||.||.||:::|..|||..
Zfish   140 SLKNNRIRNLDDYIFSKYTQMQRLFLQNNIIETVSSRAFSRLFTLQRLFLSQNNITYLGPGVFRD 204

  Fly   226 LHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQLPKIP--TLYE-----VYLDF 283
            ||.|.||.|.:|.|.|:..:.....|.|.:       |::.||.|.::|  :|.:     .:|||
Zfish   205 LHKLDWLVLDHNPLKHITRDTFIGLRSLTY-------LSMVNVSLMRLPNSSLCQHMPLLTWLDF 262

  Fly   284 --NRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNT 346
              |.:|.:...|......|.:|....|.|..:....|.:|.::.::.|..|.|.:|...||....
Zfish   263 AENDVELLNYSTLMTCTELTVLTFHDNNIKTLPENTFHSLGSLAELDLSCNRISKLPKNTFKSLK 327

  Fly   347 RLEALSLALMP-IHISSSLMEPL-NISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTP 409
            .|:.|:::..| :||.:...:.| .:..|:|.||...:|..:....|.||::|.:..|.|||..|
Zfish   328 YLKKLNISHNPLLHIHTGHFDHLVQLQSLSLEGIEIPNITTKMFLPMGNLSHIYFKDFQYCSYAP 392

  Fly   410 RVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLAL 474
            .||.|||:|||:||.:|||:..|||.|.||||.:|..||:.|:..|...|.||......|:.|..
Zfish   393 HVRKCKPNTDGISSVEDLLASLVLRVSVWVMAFITCFGNLFVIGMRSFIRAENNLHAACIKVLCF 457

  Fly   475 ADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLI 539
            ||.|||.||..:|:.|.::|.||.:..|.|:.|.:|..||.||:.|||||:|:|.:::||:||:|
Zfish   458 ADCLMGVYLFFLGIFDVKFRGEYNRNALIWMDSVECRTIGFLAMLSSEVSVLLLTYLTLEKFLVI 522

  Fly   540 ADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVL---LWRTSTLPYYGSYSGTCFPLH---IHE 598
            ..|| .|.........|.|..||..|..:|..|:|   |:..    |||. :|.|||||   :.:
Zfish   523 VFPF-SHLRPAKLQTVLILAFIWFLGFVIAAVPLLNEDLFGN----YYGR-NGVCFPLHSDRLEK 581

  Fly   599 AFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTR-SATPLTL---LDCEFAVRFFFIVLT 659
            ....|  ||..:|||:||:..::|.:.|:::..||::|. :||.:..   .|...|.||||||.:
Zfish   582 PTAKG--YSTGIFLGLNLVAFLVIVISYSSMFCSIYKTGINATDVRSRLHKDVAVANRFFFIVFS 644

  Fly   660 DFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQI--FLRGWKK 722
            |.|||:||.::|........|...|.:|:|:|:||:|||:||:|||.||..:|.|:  .|..|::
Zfish   645 DALCWIPIFLVKTLSLMKVEIPGTINSWVVIFILPINSALNPILYTLTTSFFREQVELLLCRWQR 709

  Fly   723 ITSRKRAEAGNGNVATTTTGTATGSSQHPD 752
            .::.|:   ...:|.::|....|  |::|:
Zfish   710 RSATKK---DRKSVTSSTIYMET--SRNPE 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	11/32 (34%)
		LRR_8	179..239	CDD:290566	29/59 (49%)
		leucine-rich repeat	181..204	CDD:275380	9/22 (41%)
		LRR_RI	<196..354	CDD:238064	52/166 (31%)
		leucine-rich repeat	205..228	CDD:275380	12/22 (55%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..275	CDD:275380	6/23 (26%)
		LRR_8	274..334	CDD:290566	16/68 (24%)
		leucine-rich repeat	276..299	CDD:275380	7/29 (24%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		7tm_1	447..704	CDD:278431	104/266 (39%)
rxfp2a	NP_001315313.1	LDLa	42..77	CDD:238060	12/36 (33%)
		leucine-rich repeat	136..159	CDD:275380	8/22 (36%)
		LRR_8	158..218	CDD:290566	29/59 (49%)
		leucine-rich repeat	160..183	CDD:275380	9/22 (41%)
		leucine-rich repeat	184..207	CDD:275380	12/22 (55%)
		leucine-rich repeat	208..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..256	CDD:275380	7/30 (23%)
		LRR_8	255..315	CDD:290566	14/59 (24%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	6/22 (27%)
		LRR_8	304..360	CDD:290566	14/55 (25%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	6/22 (27%)
		leucine-rich repeat	353..371	CDD:275380	5/17 (29%)
		7tm_4	422..>647	CDD:304433	90/232 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3072
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1949
OMA	1	1.010	-	-		QHG47748
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	1	1.000	-	-		otm25686
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980