DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and TSHR

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_000360.2	Gene:	TSHR / 7253	HGNCID:	12373	Length:	764	Species:	Homo sapiens

Alignment Length:	750	Identity:	166/750 - (22%)
Similarity:	270/750 - (36%)	Gaps:	217/750 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 CQCGQ--GTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISR 193
            |:|.|  ...:.|   ..::|.|.|......|.:|..:| |:..:.|:|..          ||||
Human    29 CECHQEEDFRVTC---KDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLP----------NISR 80

  Fly   194 VPLGSFSGLFHLERLELSHN--NVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWL 256
            :.:.....|..||    ||:  |:|.:.|.......:|  .::..:.|..||:  |:|
Human    81 IYVSIDVTLQQLE----SHSFYNLSKVTHIEIRNTRNL--TYIDPDALKELPL--LKF------- 130

  Fly   257 VLSRNRLTLRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHN-LITHIHGRAFAN 320
                  |.:.|..|...|.|.:||               ..|...:|::..| .:|.|...||..
Human   131 ------LGIFNTGLKMFPDLTKVY---------------STDIFFILEITDNPYMTSIPVNAFQG 174

  Fly   321 LTN-MRDIRLVGNPIKELSGETFLHNTRLEALSL------------ALMPIHISSSLME------ 366
            |.| ...::|..|....:.|..| :.|:|:|:.|            |...::...||::
Human   175 LCNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSV 238

  Fly   367 -------------------------PLNISFLNLTGIRYD------------------------- 381
                                     ||::|||:||  |.|
Human   239 TALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLT--RADLSYPSHCCAFKNQKKIRGILESLMC 301

  Fly   382 ---------------------HIDFEA---------------INSMRNLTYII------------ 398
                                 |.::|.               .::..|..|.:
Human   302 NESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGF 366

  Fly   399 ------------------YDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTI 445
                              || :..|..:..: :|.|.:|..:..:|::....||...|.::.|.:
Human   367 GQELKNPQEETLQAFDSHYD-YTICGDSEDM-VCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLAL 429

  Fly   446 AGNVLVLWGRFIYRDENVAVTM---VIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITS 507
            .|||.||   .|....:..:.:   ::.|||.||..||.||:.|...|....:|||...:||.|.
Human   430 LGNVFVL---LILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTG 491

  Fly   508 WQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAP 572
            ..|...|...|.:||:|:..|..::|||:..|....|..|.|..|.....::..|:....||:.|
Human   492 PGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLP 556

  Fly   573 VLLWRTSTLPYYGSYSGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTR 637
            ::     .:..|...| .|.|:....  |:...|..|| |.:|::..|::...|..:.|:: |..
Human   557 LV-----GISSYAKVS-ICLPMDTET--PLALAYIVFV-LTLNIVAFVIVCCCYVKIYITV-RNP 611

  Fly   638 SATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFN---YNISDDIYAWLVVFVLPLNSAV 699
            ...|.. .|.:.|.|...::.|||:|..||....:....|   ..:|:.  ..|:|...||||..
Human   612 QYNPGD-KDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNS--KILLVLFYPLNSCA 673

  Fly   700 NPLLYTFTTPKYRNQIFLRGWKKITSRKRAEAGNG 734
            ||.||...|..::..:|:...|....:::|:|..|
Human   674 NPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	13/61 (21%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		LRR_RI	<196..354	CDD:238064	38/173 (22%)
		leucine-rich repeat	205..228	CDD:275380	7/24 (29%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..275	CDD:275380	3/21 (14%)
		LRR_8	274..334	CDD:290566	15/61 (25%)
		leucine-rich repeat	276..299	CDD:275380	3/22 (14%)
		leucine-rich repeat	300..323	CDD:275380	7/23 (30%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tm_1	447..704	CDD:278431	76/262 (29%)
TSHR	NP_000360.2	leucine-rich repeat	54..77	CDD:275380	6/32 (19%)
		LRR_5	66..221	CDD:290045	45/201 (22%)
		leucine-rich repeat	78..102	CDD:275380	9/27 (33%)
		leucine-rich repeat	103..127	CDD:275380	4/25 (16%)
		leucine-rich repeat	147..179	CDD:275380	11/46 (24%)
		leucine-rich repeat	180..201	CDD:275380	4/21 (19%)
		leucine-rich repeat	202..229	CDD:275380	4/26 (15%)
		7tm_4	417..609	CDD:304433	59/204 (29%)
		7tm_1	431..678	CDD:278431	76/262 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810