DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr3 and RXFP1

DIOPT Version :9

Sequence 1:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_001240656.1 Gene:RXFP1 / 59350 HGNCID:19718 Length:784 Species:Homo sapiens


Alignment Length:739 Identity:254/739 - (34%)
Similarity:378/739 - (51%) Gaps:45/739 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VIF--YLSLG-----PCPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIAD 80
            :||  |.|.|     .|....|.|.|.|.|:|:...|:..:||.:.:||:  .||...|.....|
Human    11 LIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED--NCGDNNGWSLQFD 73

  Fly    81 KIVRNAIEKKQQRLISAVSNASGAD-----STTSMVPR-NQSLTLNMTCDIVTYPKACQCGQGTI 139
            |...:..:...|....|.:......     :...:||. :.:|.|.:...:.:.|..|.| ||..
Human    74 KYFASYYKMTSQYPFEAETPECSFHFFLFITLLFLVPHCHHALPLPLDSVVGSVPVQCLC-QGLE 137

  Fly   140 LYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLF 203
            |.|.. ..||..|.:||.||.:.:..|.: .|..:.|.|:..||||.|:.|.|:.:.:.:|.||.
Human   138 LDCDE-TNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLN 201

  Fly   204 HLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNV 268
            .|.:|.||||.::.|..|||..||.|:||.:.:|||..:..........|..|||..|.||    
Human   202 SLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLT---- 262

  Fly   269 QLP------KIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFANLTNMRDI 327
            :||      .:|.|:.:.|:.|.|..:...||....||.:|.::.|.|.|::...||.|..:.::
Human   263 RLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL 327

  Fly   328 RLVGNPIKELSGETFLHNTRLEALSLALMPIH-ISSSLMEPL-NISFLNLTGIRYDHIDFEAINS 390
            .|..|.|:.|....|.....|..|:|:..||. |.::..:.| .:..|:|.||...:|.......
Human   328 DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 392

  Fly   391 MRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGR 455
            :.||::|.:.:|.||...|.||.|||:|||:||.::||:..:.|...||::.:|..||:.|:..|
Human   393 LMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMR 457

  Fly   456 FIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSS 520
            ...|.||....|.|.:|..||.|||.||..||..|.::|.||.|....|:.|..|.|:|:||:.|
Human   458 PYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILS 522

  Fly   521 SEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYG 585
            :|||:|:|.|::||:::.|..|||..|....|.: ..||.|||||..:|..|:     |...::.
Human   523 TEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTI-TVLILIWITGFIVAFIPL-----SNKEFFK 581

  Fly   586 SYSGT---CFPLHIHEAFPMG-WLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTR-SATPL--- 642
            :|.||   |||||..:...:| .:||..:|||:||...::|...|.::..|:.::. :||.:   
Human   582 NYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQ 646

  Fly   643 TLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFT 707
            ...:...|.||||||.||.|||:||.|:|........|...|.:|:|:|:||:|||:||:|||.|
Human   647 VKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLT 711

  Fly   708 TPKYRNQIFLRGWKKITSRKRAEA 731
            |..::..|. |.|.....||..::
Human   712 TRPFKEMIH-RFWYNYRQRKSMDS 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr3NP_733115.1 LDLa 32..65 CDD:238060 11/32 (34%)
LRR_8 179..239 CDD:290566 26/59 (44%)
leucine-rich repeat 181..204 CDD:275380 10/22 (45%)
LRR_RI <196..354 CDD:238064 53/163 (33%)
leucine-rich repeat 205..228 CDD:275380 11/22 (50%)
leucine-rich repeat 229..252 CDD:275380 6/22 (27%)
leucine-rich repeat 253..275 CDD:275380 9/27 (33%)
LRR_8 274..334 CDD:290566 18/59 (31%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
leucine-rich repeat 300..323 CDD:275380 8/22 (36%)
leucine-rich repeat 324..347 CDD:275380 5/22 (23%)
7tm_1 447..704 CDD:278431 105/264 (40%)
RXFP1NP_001240656.1 LDLa 27..62 CDD:238060 12/36 (33%)
leucine-rich repeat 155..178 CDD:275380 6/22 (27%)
LRR_8 179..237 CDD:290566 26/57 (46%)
leucine-rich repeat 179..202 CDD:275380 10/22 (45%)
LRR_RI <196..358 CDD:238064 54/165 (33%)
leucine-rich repeat 203..226 CDD:275380 11/22 (50%)
LRR_8 226..286 CDD:290566 19/63 (30%)
leucine-rich repeat 227..250 CDD:275380 6/22 (27%)
leucine-rich repeat 251..275 CDD:275380 9/27 (33%)
LRR_8 274..334 CDD:290566 18/59 (31%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
leucine-rich repeat 300..323 CDD:275380 8/22 (36%)
LRR_8 323..379 CDD:290566 14/55 (25%)
leucine-rich repeat 324..347 CDD:275380 5/22 (23%)
leucine-rich repeat 348..371 CDD:275380 7/22 (32%)
leucine-rich repeat 372..393 CDD:275380 5/20 (25%)
7tm_1 451..708 CDD:278431 103/262 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 193 1.000 Domainoid score I3192
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 394 1.000 Inparanoid score I1979
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47748
OrthoDB 1 1.010 - - D256258at33208
OrthoFinder 1 1.000 - - FOG0002061
OrthoInspector 1 1.000 - - otm41016
orthoMCL 1 0.900 - - OOG6_101648
Panther 1 1.100 - - O PTHR24372
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4149
SonicParanoid 1 1.000 - - X1524
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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