DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and rxfp2b

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001315011.1	Gene:	rxfp2b / 566888	ZFINID:	ZDB-GENE-110408-27	Length:	750	Species:	Danio rerio

Alignment Length:	759	Identity:	261/759 - (34%)
Similarity:	385/759 - (50%)	Gaps:	82/759 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RSIAVGFCLMTVVLLLAAVIFYLSLG-------PCPAASFACDNGTLCVPRRQMCDSRNDCADSS 62
            :|.|....|...::|....|.....|       .||...|.|.|.::|:|:...|:::.||.:.:
Zfish     5 QSAATASALELCLILFTTSITTAKAGQEHRPSEDCPLGHFPCGNVSICLPQVLHCNNQKDCPNGA 69

  Fly    63 DENPVECGLLYGSKEIADKIVRNAIEKKQQRLISAVSNASGADSTTSMVPRNQSLTLNMTCDIVT 127
            ||:  .||                            .|:..||.......|.....|...|.:..
Zfish    70 DED--NCG----------------------------DNSGWADLFDRTFKRGYLQELATDCQVEQ 104

  Fly   128 YPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNI 191
            ||..|:| ..|.::| .:|.||..|::|:.||:|.:..|.: ||.|..|..:.:||:|.|:.|.|
Zfish   105 YPDVCRC-INTEIHC-VHASLRSIPQVSANVTSLSLKSNKIRTLPDEAFIKYIKLQRLFLQDNCI 167

  Fly   192 SRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQL--RFFRRLE 254
            :.|.:.:||||:.|::|.||.|::|.|..|||..|..|:||.|.:|     |:..:  ..|..|.
Zfish   168 NTVSIQAFSGLYKLQKLSLSQNSISLLSPGVFRDLRKLKWLILDDN-----PITTIAANTFAGLS 227

  Fly   255 WLVLSRNRLTLRNVQLPKIPTL-------YEVYLDF--NRIEYIGEETFSQLDNLHLLDLQHNLI 310
            .|..    |::.|..|..:|:.       :..:|||  |.|..:|..|....::|.:|.|:.|||
Zfish   228 SLFF----LSMVNTSLEALPSARLCAHMPFLSWLDFEGNSITTLGLSTLLDCEHLTVLSLRANLI 288

  Fly   311 THIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPI-HISSSLMEPL-NISFL 373
            ..:....|.:|..|.|:.|..|.||||....|.....|::|:|:..|: ||.......| .:..|
Zfish   289 KSLPENTFQSLRMMGDLDLSNNSIKELPVGIFKDLRSLQSLNLSQNPLDHIHPGQFNHLIQLQSL 353

  Fly   374 NLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAW 438
            .|.|:...:|.......|.||:||.:.:|.|||..|.||.|||::||:|||:|||:..|||.|.|
Zfish   354 GLEGVEIPNIQTSMFRPMDNLSYIYFKKFQYCSYAPHVRKCKPNSDGLSSFEDLLANVVLRVSVW 418

  Fly   439 VMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLD 503
            |||.:|..||:.|:..|.:.|.||......|:.|..||.|||.||..:|:.|.::|.||.|....
Zfish   419 VMAFITCFGNLFVIGMRTVLRAENNLHAFCIKVLCCADCLMGVYLFFVGIFDVKFRGEYNKNAKV 483

  Fly   504 WITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGL 568
            |:.|.:|..||.||:.|||||:::|.:::||:||:|..|| .|........:..|:.||:.|:.:
Zfish   484 WMESLECRTIGFLAMLSSEVSVMLLTYLTLEKFLVIVFPF-SHLRPSKCQTFTVLVSIWLLGISI 547

  Fly   569 AVAPVLLWRTSTLPYYGSYSGTCFPLHIHE-AFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLIS 632
            |..|:|  ...|...|...:|.|||||... ..|:...||..:|||:|||..::|.:.|:::..|
Zfish   548 AAVPLL--NEDTFGNYYGLNGVCFPLHSERLEKPVAKGYSTGIFLGLNLLAFLIIVVSYSSMFYS 610

  Fly   633 IWRTR-SATPL---TLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVL 693
            |::|. .||.|   ...|...|.||||||.:|.|||:||.::||.......|...|.:|:|:|:|
Zfish   611 IYKTGIRATELPGRLHRDVAMAHRFFFIVFSDALCWIPIFMVKILSLLEVEIPGTITSWVVIFIL 675

  Fly   694 PLNSAVNPLLYTFTTPKYRNQI------------FLRGWKKITS 725
            |:|||:||:|||.||..:|.|:            ..:|.|.:||
Zfish   676 PINSALNPILYTLTTSFFREQVEHLWGHWQRQPRLKQGRKSLTS 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	11/32 (34%)
		LRR_8	179..239	CDD:290566	27/59 (46%)
		leucine-rich repeat	181..204	CDD:275380	11/22 (50%)
		LRR_RI	<196..354	CDD:238064	54/168 (32%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	7/24 (29%)
		leucine-rich repeat	253..275	CDD:275380	5/21 (24%)
		LRR_8	274..334	CDD:290566	20/68 (29%)
		leucine-rich repeat	276..299	CDD:275380	7/31 (23%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		7tm_1	447..704	CDD:278431	103/261 (39%)
rxfp2b	NP_001315011.1	LDLa	39..74	CDD:238060	12/36 (33%)
		leucine-rich repeat	114..132	CDD:275380	7/18 (39%)
		LRR_RI	130..360	CDD:238064	78/238 (33%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR_8	156..215	CDD:290566	27/63 (43%)
		leucine-rich repeat	157..180	CDD:275380	11/22 (50%)
		leucine-rich repeat	181..204	CDD:275380	11/22 (50%)
		LRR_8	203..288	CDD:290566	24/93 (26%)
		leucine-rich repeat	205..228	CDD:275380	8/27 (30%)
		leucine-rich repeat	229..253	CDD:275380	5/27 (19%)
		leucine-rich repeat	254..277	CDD:275380	7/22 (32%)
		LRR_8	277..336	CDD:290566	20/58 (34%)
		leucine-rich repeat	278..301	CDD:275380	8/22 (36%)
		leucine-rich repeat	302..325	CDD:275380	9/22 (41%)
		LRR_8	324..378	CDD:290566	15/53 (28%)
		leucine-rich repeat	326..349	CDD:275380	7/22 (32%)
		leucine-rich repeat	350..369	CDD:275380	4/18 (22%)
		7tm_4	419..>556	CDD:304433	54/139 (39%)
		7tm_1	<487..686	CDD:278431	80/201 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3072
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1949
OMA	1	1.010	-	-		QHG47748
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	1	1.000	-	-		otm25686
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840