DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr3 and tshr

DIOPT Version :10

Sequence 1:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_001139235.1 Gene:tshr / 560609 ZFINID:ZDB-GENE-110524-4 Length:757 Species:Danio rerio


Alignment Length:739 Identity:167/739 - (22%)
Similarity:289/739 - (39%) Gaps:145/739 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 PKACQCGQ--GTILYCGRYAKLRRFPRLSSEVTNLIIIRNNLT-LRDNIFANFTRLQKLTLKYN- 189
            |..|:|.|  ..::.|   ..:...|.|......|.:....|| :..:.|||...:.::.|..: 
Zfish    24 PHGCECSQWKALVVSC---MDVDSIPTLPERTEVLSLHETRLTRVPKDAFANMVNISRIYLSVDI 85

  Fly   190 NISRVPLGSFSGLFHLERLELSH-NNVSHLPHGVFLGLHSLQWLFLVNNHLHHLP------VEQL 247
            .:||:.:.||..|..|..:|:.: ..::.:....|..|.:||:|.|.|..|...|      .|..
Zfish    86 FLSRLEMHSFHSLRELTHIEIRNTRKLTFIHPEAFKNLPNLQYLGLFNTGLTIFPDLTKIQAENS 150

  Fly   248 RFFRRLE------------WLVLSRNRLTLR-------NVQLPKI---PTLYEVYLDFNR-IEYI 289
            .|...:.            :..::.:.|:||       .|| |..   ..|..|||..|| :..:
Zfish   151 YFILEISDNPYIAEIPANAFFGITNDLLSLRLYSNGFTKVQ-PHAFNGTKLDSVYLHRNRELTRL 214

  Fly   290 GEETFSQLDN-LHLLDLQHNLITHIHGR------------------------------------- 316
            .|:.|:...: ..|||:..:.:|.:..|                                     
Zfish   215 DEKMFAGTSSGPMLLDVSESGVTSLPARGLDSLRELCARNVWALKKLPPIKTFRHLVTADLTYPS 279

  Fly   317 ---AFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSSLMEP-LNISFLNLTG 377
               ||.||...|..      |:|:.........:::..|:....||.....||| :::|. ||..
Zfish   280 HCCAFKNLKKKRGF------IEEIICNLTARKNQVQKRSVRAFTIHGLQGSMEPGIDLSD-NLFR 337

  Fly   378 IRYDHIDF---------------------EAINSMRNLTYIIYD-RFFY--CSMTPRVRMCKPST 418
            ..|||.:|                     |.:.:.:..|...:| |:.|  |.....| .|.|:.
Zfish   338 DTYDHQEFFGNGHYPTYFDRHADENMGFGETLKNPQEDTSREFDSRYDYIVCEKGEEV-ACFPAP 401

  Fly   419 DGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYL 483
            |..:..:|::....||.|.|.::.|.:.||:|||........:......::.:||:||:.||.||
Zfish   402 DEFNPCEDIMGFSFLRVSVWFVSLLAVLGNLLVLLVLLTSHYKLSVSRFLMCHLAVADLCMGIYL 466

  Fly   484 VTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRS 548
            :.|...|...::|||...:||.|...|:|.|..:|.:||:|:..|..::|||:..|....|..|.
Zfish   467 LLIASVDLHTQSEYYNHAIDWQTGPGCSLAGFFSVFASELSVYTLTTITLERWYAITYAMRLDRK 531

  Fly   549 IGNRVMWLALICI--WITGVGLAVAPVLLWRTSTLPYYGSYS--GTCFPLHIHEAFPMGWLYSAF 609
            :  |:...::|.:  ||..:.|.:.|        |....||.  ..|.|:.........::....
Zfish   532 L--RLSHASVIMLIGWIFCLLLGLMP--------LVGVSSYQKVSICLPMDTQTLVDQIYIICVL 586

  Fly   610 VFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWV 674
            |   :|:|..::|.:.|..:..::......:  :..|...|.|...::.|||||..||.:..:..
Zfish   587 V---LNILAFIVICVCYIKIYCAVHNPSHQS--SNKDTNIAKRMAVLIFTDFLCMAPISLYAMTA 646

  Fly   675 FFNY---NISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRKRAEAGNGNV 736
            ..::   .:|:.  ..|:|...||||..||.||...|..::..:|:...|....:::|:...|..
Zfish   647 VLDHPLITVSNS--KILLVLFYPLNSCANPFLYAIFTKAFQGDVFILLSKVGLCQRQAQLFRGQT 709

  Fly   737 ATTTTGT---------ATGSSQHP 751
            .::...:         .||:::.|
Zfish   710 VSSKASSRGITRHEREQTGANETP 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr3NP_733115.1 LDLa 32..65 CDD:238060
LRR 85..389 CDD:443914 72/356 (20%)
leucine-rich repeat 181..204 CDD:275380 6/23 (26%)
leucine-rich repeat 205..228 CDD:275380 4/23 (17%)
leucine-rich repeat 229..252 CDD:275380 9/28 (32%)
leucine-rich repeat 253..275 CDD:275380 6/43 (14%)
leucine-rich repeat 276..299 CDD:275380 8/23 (35%)
leucine-rich repeat 300..323 CDD:275380 9/62 (15%)
leucine-rich repeat 324..347 CDD:275380 3/22 (14%)
7tmA_Relaxin_R 431..715 CDD:320265 78/290 (27%)
TM helix 1 432..458 CDD:320265 10/25 (40%)
TM helix 2 465..490 CDD:320265 9/24 (38%)
TM helix 3 510..540 CDD:320265 11/29 (38%)
TM helix 4 552..574 CDD:320265 6/23 (26%)
TM helix 5 603..632 CDD:320265 5/28 (18%)
TM helix 6 644..674 CDD:320265 10/29 (34%)
TM helix 7 683..708 CDD:320265 10/24 (42%)
tshrNP_001139235.1 leucine-rich repeat 52..75 CDD:275380 6/22 (27%)
leucine-rich repeat 76..100 CDD:275380 6/23 (26%)
leucine-rich repeat 101..125 CDD:275380 4/23 (17%)
LRR <108..>275 CDD:443914 30/167 (18%)
leucine-rich repeat 145..175 CDD:275380 2/29 (7%)
leucine-rich repeat 177..199 CDD:275380 6/22 (27%)
leucine-rich repeat 200..224 CDD:275380 8/23 (35%)
7tm_GPCRs 415..688 CDD:475119 78/289 (27%)
TM helix 1 416..440 CDD:320630 10/23 (43%)
TM helix 2 449..470 CDD:320630 8/20 (40%)
TM helix 3 494..516 CDD:320630 7/21 (33%)
TM helix 4 539..555 CDD:320630 4/15 (27%)
TM helix 5 579..602 CDD:320630 5/25 (20%)
TM helix 6 622..644 CDD:320630 9/21 (43%)
TM helix 7 656..681 CDD:320630 11/26 (42%)
Blue background indicates that the domain is not in the aligned region.

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