DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lgr3 and lgr4

DIOPT Version :9

Sequence 1:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_001340791.1 Gene:lgr4 / 558825 ZFINID:ZDB-GENE-111013-1 Length:971 Species:Danio rerio


Alignment Length:833 Identity:184/833 - (22%)
Similarity:307/833 - (36%) Gaps:234/833 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 CQCGQGTILYC-GRYAKLRRFPR-LSSEVTNLIIIRNNLT-LRDNIFANFTRLQK---------- 183
            |:|.:.....| ||  .|...|. ||:....|.|..||:| |..|:|.|...|::          
Zfish    36 CRCDEDGGADCSGR--GLTSVPTGLSAFTYYLDISMNNITELPANVFRNLPYLEELRLAGNDLAF 98

  Fly   184 --------------LTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFL 234
                          |.|:.|.:..||..:...|..|:.|.|..|:::.:|...|.||..|:.|:|
Zfish    99 IHPEALSGLHQLKVLMLQNNQLKTVPSAALKNLNALQSLRLDANHITSVPEDSFEGLQQLRHLWL 163

  Fly   235 VNNHLHHLPVEQLRFFRRLEWLVLSRNRLT-LRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLD 298
            .:|.|..:|:..|:....|:.|.|:.||:| :.:.....:.:|..::|..|||:.||:..|:.||
Zfish   164 DDNSLTEVPISPLQHQSNLQALTLALNRITHIPDNAFANLSSLVVLHLHNNRIQEIGKNCFNGLD 228

  Fly   299 NLHLLDLQHN-------------------------------------LITHIH----------GR 316
            ||..|||..|                                     |:..||          ..
Zfish   229 NLETLDLNFNNLKIFPEAIQMLPKLKELGFHSNNIASIPEGAFCRNSLLRTIHLFDNPLSFVGTT 293

  Fly   317 AFANLTN---------------------------------------------------------- 323
            ||.||::                                                          
Zfish   294 AFQNLSDLHSLMLRGASMMQDFPSLTGTINLESLTLTGTKIRSIPADLCEDLTVLRTVDLSYNDI 358

  Fly   324 -----------MRDIRLVGNPIKELSGETFLHNTRLEALSLA---LMPIH----ISSSLMEPLNI 370
                       ::||.|..|.||::...||...|.|..|.|:   :..||    :|.|.:..|::
Zfish   359 EDLPSFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDL 423

  Fly   371 SF----------------LNLTG---IRYDHIDFEAINSMRNLT---------YIIYDRFFY--- 404
            |.                |.|||   :| :.:..:.:..:|::|         ::.||....   
Zfish   424 SLNSLASVPTAGLSALNQLKLTGNMELR-NGLMSKTLPKLRSITVPYAYQCCAFVAYDSAVNPAE 487

  Fly   405 -------------CSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRF 456
                         ....|.|..|.|........:.||...::|.:.|.:..:.:..|.|||...|
Zfish   488 DDERRNAFGGEEDMERIPMVMHCSPLPGAFKPCEHLLGSWMIRLTVWFICLVALLFNCLVLAATF 552

  Fly   457 IYRDENVAVT-MVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSS 520
            ..|..:::.: .::..||.|::|.|.|:..:.:.|......:.:..:.|.|...|.::|.|||.|
Zfish   553 SPRTSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVWWETGAGCQVVGFLAVFS 617

  Fly   521 SEVSMLILAFMSLERFLLI--------ADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWR 577
            ||.::|:||..::||.|.:        |...||.|....|...:|.:.:.:..|..|...:    
Zfish   618 SEWAVLLLALAAVERCLAVRALMGKAGALRSRGERRERRRRFAIAALLLGLVSVAAACLSL---- 678

  Fly   578 TSTLPYYGSYSGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPL 642
                 |:||..|:...|...|....|..::..:.| :|.|..::.|::||.|...:.|.:.|.| 
Zfish   679 -----YHGSAMGSPLCLPFSEGSSPGLGFTVALVL-MNTLAYLLSAVVYTRLYCRLGRAQLADP- 736

  Fly   643 TLLDCEFAVRFF-FIVLTDFLCWVPIIVMKIWVFF----NYNISDDIYAWLVVFVLPLNSAVNPL 702
               :...:||.. :::.|:.:.:.|:.........    |.....::...:.:...||::.:||:
Zfish   737 ---EQAGSVRHIAWLIFTNCIFFCPVAAFSFAPLLAGTSNAVGGPEMAKSVTLIFFPLSACLNPV 798

  Fly   703 LYTFTTPKYRNQIFLRGWKKITSRKRAEAGNGNVA--TTTTGTATGSSQHPDD 753
            ||...:|.:|..     |..:..|.|. .|.|.:.  |.|.||..|.|...||
Zfish   799 LYVCFSPSFRYD-----WLHLRGRGRT-GGCGRLVAKTVTKGTVAGGSPVSDD 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr3NP_733115.1 LDLa 32..65 CDD:238060
LRR_8 179..239 CDD:290566 19/83 (23%)
leucine-rich repeat 181..204 CDD:275380 7/46 (15%)
LRR_RI <196..354 CDD:238064 56/274 (20%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
leucine-rich repeat 253..275 CDD:275380 6/22 (27%)
LRR_8 274..334 CDD:290566 27/175 (15%)
leucine-rich repeat 276..299 CDD:275380 9/22 (41%)
leucine-rich repeat 300..323 CDD:275380 12/69 (17%)
leucine-rich repeat 324..347 CDD:275380 8/22 (36%)
7tm_1 447..704 CDD:278431 63/270 (23%)
lgr4NP_001340791.1 LRR 1 58..82 10/23 (43%)
leucine-rich repeat 64..85 CDD:275380 9/20 (45%)
LRR_8 84..144 CDD:316378 11/59 (19%)
LRR 2 84..106 1/21 (5%)
leucine-rich repeat 86..109 CDD:275380 1/22 (5%)
LRR 3 107..130 5/22 (23%)
leucine-rich repeat 110..133 CDD:275380 6/22 (27%)
LRR 4 131..154 7/22 (32%)
leucine-rich repeat 134..157 CDD:275380 8/22 (36%)
LRR 137..>452 CDD:227223 66/315 (21%)
LRR 5 156..178 7/21 (33%)
leucine-rich repeat 158..181 CDD:275380 7/22 (32%)
LRR 6 179..202 6/22 (27%)
leucine-rich repeat 182..205 CDD:275380 6/22 (27%)
LRR 7 204..226 8/21 (38%)
leucine-rich repeat 206..229 CDD:275380 9/22 (41%)
LRR 8 227..250 8/22 (36%)
leucine-rich repeat 230..252 CDD:275380 5/21 (24%)
LRR_8 251..308 CDD:316378 7/56 (13%)
LRR 9 251..273 0/21 (0%)
leucine-rich repeat 253..276 CDD:275380 0/22 (0%)
LRR 10 275..297 5/21 (24%)
leucine-rich repeat 277..298 CDD:275380 4/20 (20%)
LRR 11 299..321 0/21 (0%)
LRR 12 322..344 0/21 (0%)
LRR 13 345..366 0/20 (0%)
leucine-rich repeat 348..369 CDD:275380 0/20 (0%)
LRR 14 367..390 8/22 (36%)
leucine-rich repeat 370..393 CDD:275380 8/22 (36%)
LRR 15 391..414 6/22 (27%)
leucine-rich repeat 394..415 CDD:275380 5/20 (25%)
LRR 16 416..438 3/21 (14%)
leucine-rich repeat 418..438 CDD:275380 2/19 (11%)
7tmA_LGR4 527..811 CDD:320483 69/302 (23%)
TM helix 1 528..554 CDD:320483 7/25 (28%)
TM helix 2 562..587 CDD:320483 6/24 (25%)
TM helix 3 607..637 CDD:320483 14/29 (48%)
TM helix 4 649..679 CDD:320483 7/38 (18%)
TM helix 5 698..727 CDD:320483 8/29 (28%)
TM helix 6 736..766 CDD:320483 5/33 (15%)
TM helix 7 779..804 CDD:320483 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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