DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and LGR4

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_060960.2	Gene:	LGR4 / 55366	HGNCID:	13299	Length:	951	Species:	Homo sapiens

Alignment Length:	735	Identity:	167/735 - (22%)
Similarity:	284/735 - (38%)	Gaps:	175/735 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 SMVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNLIIIRNN--LTLR 171
            |.:|..|:|||.:. .|.:.|...                  |..|||.|  ::.:.||  .:|.
Human   174 SNLPTLQALTLALN-KISSIPDFA------------------FTNLSSLV--VLHLHNNKIRSLS 217

  Fly   172 DNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVN 236
            .:.|.....|:.|.|.|||:...| .:...|..|:.|....|::|.:|.|.|.|...|:.:.|.:
Human   218 QHCFDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYD 281

  Fly   237 N--------------HLHHLPVEQLRFFRRLEWL--VLSRNRLTLRNVQLPKIP----------- 274
            |              .||.|.:......::...|  .:....|||...::..||
Human   282 NPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLR 346

  Fly   275 -------------------TLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFAN 320
                               .|.|:.|..|:|..|.|.||..|.:|.:|||..|||..||.||||.
Human   347 TLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411

  Fly   321 L---TN------------------MRDIRLVGN-PIKE-LSGETFLHNTRLEALSLALMPIHISS 362
            |   ||                  :..::|||| .:|| |:.:.|: |.|
Human   412 LGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFV-NLR--------------- 460

  Fly   363 SLMEPLNISFLNLTGI-RYDHIDFEAINSMR--------------NLTYIIYDRFFYCSMTPRVR 412
            ||..|.........|. .|.:::.|. ||::              |:|..:.:.    ..:..:.
Human   461 SLSVPYAYQCCAFWGCDSYANLNTED-NSLQDHSVAQEKGTADAANVTSTLENE----EHSQIII 520

  Fly   413 MCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADM 477
            .|.|||......:.||...::|.:.|.:..:.:..|:||:...|.......:..:.|..::::::
Human   521 HCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNL 585

  Fly   478 LMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADP 542
            .||.|...:...|......:.:..:.|.|...|.:.|.|||.|||.::.:|...::||.|...|.
Human   586 FMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDI 650

  Fly   543 FRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYY--GSYSGT--CFPLHIHEAFPMG 603
            .:..:|...:...:|.:..::   |..||       ...|.:  |.||.:  |.|....|...:|
Human   651 MKNGKSNHLKQFRVAALLAFL---GATVA-------GCFPLFHRGEYSASPLCLPFPTGETPSLG 705

  Fly   604 WLYSAFVFLGVNLLLLVMIAMLYTALLISIWR-----------TRSATPLTLLDCEFAVRFFFIV 657
            :..:..:   :|.|..:::|::||.|..::.:           .:....|...:|     .||..
Human   706 FTVTLVL---LNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNC-----IFFCP 762

  Fly   658 LTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKK 722
            :. |..:.|:|..       .:||.:|...:.:...||.:.:||:||.|..||::..     ||.
Human   763 VA-FFSFAPLITA-------ISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED-----WKL 814

  Fly   723 ITSRKRAEAGNGNVATTTTG 742
            :..|...::|:.:|:.::.|
Human   815 LKRRVTKKSGSVSVSISSQG 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	19/73 (26%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	57/226 (25%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	6/36 (17%)
		leucine-rich repeat	253..275	CDD:275380	6/53 (11%)
		LRR_8	274..334	CDD:290566	31/111 (28%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		leucine-rich repeat	300..323	CDD:275380	14/25 (56%)
		leucine-rich repeat	324..347	CDD:275380	9/24 (38%)
		7tm_1	447..704	CDD:278431	57/271 (21%)
LGR4	NP_060960.2	LRRNT	29..56	CDD:279764
		LRR_RI	<44..239	CDD:238064	23/85 (27%)
		LRR 1	58..79
		leucine-rich repeat	59..82	CDD:275380
		LRR 2	82..103
		LRR_8	83..141	CDD:290566
		leucine-rich repeat	83..106	CDD:275380
		LRR 3	106..127
		leucine-rich repeat	107..130	CDD:275380
		LRR 4	130..151
		LRR_8	131..189	CDD:290566	6/15 (40%)
		leucine-rich repeat	131..154	CDD:275380
		LRR 5	154..177		1/2 (50%)
		leucine-rich repeat	155..178	CDD:275380	1/3 (33%)
		LRR_8	177..237	CDD:290566	21/80 (26%)
		LRR 6	178..199		7/39 (18%)
		leucine-rich repeat	179..202	CDD:275380	8/41 (20%)
		LRR 7	202..223		6/22 (27%)
		leucine-rich repeat	203..226	CDD:275380	5/24 (21%)
		LRR_RI	221..426	CDD:238064	55/205 (27%)
		LRR 8	226..247		7/21 (33%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		LRR_8	248..305	CDD:290566	14/56 (25%)
		LRR 9	249..270		7/20 (35%)
		leucine-rich repeat	250..273	CDD:275380	8/22 (36%)
		LRR 10	273..294		3/20 (15%)
		leucine-rich repeat	274..295	CDD:275380	3/20 (15%)
		LRR 11	320..341		5/20 (25%)
		LRR 12	344..365		0/20 (0%)
		LRR_8	345..401	CDD:290566	15/55 (27%)
		leucine-rich repeat	345..366	CDD:275380	0/20 (0%)
		LRR 13	366..387		9/20 (45%)
		leucine-rich repeat	367..390	CDD:275380	10/22 (45%)
		LRR_8	390..444	CDD:290566	18/53 (34%)
		LRR 14	390..411		12/20 (60%)
		leucine-rich repeat	391..414	CDD:275380	14/22 (64%)
		LRR 15	414..435		2/20 (10%)
		leucine-rich repeat	415..438	CDD:275380	2/22 (9%)
		leucine-rich repeat	439..461	CDD:275380	10/37 (27%)
		7tm_1	556..801	CDD:278431	57/270 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810