DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and Lgr6

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	170/735 - (23%)
Similarity:	267/735 - (36%)	Gaps:	187/735 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 LRRFPRLSSEVTNLIIIRNNLTLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSH 212
            |...|.|.:....|..||:   :.|..|.|.|.|..|.|..|.|..|...||.||.:||.|:|::
  Rat   182 LNNLPALQAMTLALNRIRH---IPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNY 243

  Fly   213 -----------------------NNVSHLPHGVFLGLHSLQWLFLVNN--------------HLH 240
                                   ||:..:|...|:|...||.:...:|              .||
  Rat   244 NELQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLSKLH 308

  Fly   241 HLPVE---------QLRFFRRLEWLVLSR-----------------NRLTLRNVQLPKIPTLY-- 277
            .|.:.         .|:....||.|.|:|                 ..|.|.:.|:.::|:|:
  Rat   309 TLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPAGMCQQLPRLRILELSHNQIEELPSLHRC 373

  Fly   278 ----EVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFANLTNMRDIRLVGN-----P 333
                |:.|..|||..||.:|||||.:|..|||..|.|..||..||:.|.::..:.|..|     |
  Rat   374 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLP 438

  Fly   334 IKELSGETFLHNTRLEALSLALMPIHISSS-----LME--------------------------- 366
            :..|.|   |.:.:|:. :|||.......|     ::|
  Rat   439 LAGLGG---LMHLKLKG-NLALSQAFSKDSFPKLRILEVPYAYQCCAYGLCANFFKTSGQWQAED 499

  Fly   367 -----------PLNISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDG 420
                       ||.:    |.|...:|.|.:    :..|.....|    ....|.|: |.|....
  Rat   500 FHAEEEEAPKRPLGL----LAGQAENHYDLD----LDELQMETED----SKPHPSVQ-CSPVPGP 551

  Fly   421 VSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVA-VTMVIRNLALADMLMGFYLV 484
            ....:.|.....:|.:.|.:..|::..|.|||...|......:: |.:|:..:|.|:.|.|....
  Rat   552 FKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPSPLSPVKLVVGAIAGANALTGISCG 616

  Fly   485 TIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIA-------DP 542
            .:...|.....::.:....|.|...|...|.|||..||.|:|:|...:::..:.:.       .|
  Rat   617 LLASVDALTFGQFAEYGARWETGLGCQATGFLAVLGSEASVLLLTLAAVQCSVSVTCVRAYGKAP 681

  Fly   543 FRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAFPMGWLYS 607
            ..|....|      ||.|:.:.|:..|: |:     :::..||: |..|.|....|..|.. |..
  Rat   682 SPGSVRAG------ALGCLALAGLAAAL-PL-----ASVGEYGA-SPLCLPYAPPEGRPAA-LGF 732

  Fly   608 AFVFLGVNLLLLVMIAMLYTALLI--------SIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCW 664
            |...:.:|.|..:::|..|..|..        ::|           ||.......:::..|.|.:
  Rat   733 AVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVW-----------DCAMVRHVAWLIFADGLLY 786

  Fly   665 VPIIVMKIWVFFN-YNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRKR 728
            .|:..:....... :.::.:....:::.||||.:.:|||||....|.:|..: .|.|....|
  Rat   787 CPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFREDL-RRLWPSPRS--- 847

  Fly   729 AEAGNGNVATTTTGTATGSS 748
                .|.:|.|..|....||
  Rat   848 ----PGPLAYTAAGELEKSS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	23/96 (24%)
		leucine-rich repeat	181..204	CDD:275380	10/22 (45%)
		LRR_RI	<196..354	CDD:238064	60/231 (26%)
		leucine-rich repeat	205..228	CDD:275380	9/45 (20%)
		leucine-rich repeat	229..252	CDD:275380	7/45 (16%)
		leucine-rich repeat	253..275	CDD:275380	8/38 (21%)
		LRR_8	274..334	CDD:290566	27/70 (39%)
		leucine-rich repeat	276..299	CDD:275380	13/28 (46%)
		leucine-rich repeat	300..323	CDD:275380	11/22 (50%)
		leucine-rich repeat	324..347	CDD:275380	6/27 (22%)
		7tm_1	447..704	CDD:278431	60/273 (22%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470
		LRR_RI	<70..248	CDD:238064	24/68 (35%)
		leucine-rich repeat	70..91	CDD:275380
		LRR_8	92..150	CDD:290566
		leucine-rich repeat	92..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..198	CDD:290566	4/15 (27%)
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..187	CDD:275380	1/4 (25%)
		LRR_8	186..246	CDD:290566	23/62 (37%)
		leucine-rich repeat	188..211	CDD:275380	7/25 (28%)
		leucine-rich repeat	212..235	CDD:275380	10/22 (45%)
		leucine-rich repeat	236..258	CDD:275380	4/21 (19%)
		LRR_RI	253..>442	CDD:238064	48/188 (26%)
		LRR_8	258..314	CDD:290566	11/55 (20%)
		leucine-rich repeat	259..282	CDD:275380	5/22 (23%)
		leucine-rich repeat	283..304	CDD:275380	3/20 (15%)
		LRR_8	305..364	CDD:290566	11/58 (19%)
		leucine-rich repeat	330..344	CDD:275378	5/13 (38%)
		leucine-rich repeat	354..375	CDD:275380	5/20 (25%)
		LRR_8	375..434	CDD:290566	25/58 (43%)
		leucine-rich repeat	376..399	CDD:275380	12/22 (55%)
		leucine-rich repeat	400..421	CDD:275380	10/20 (50%)
		leucine-rich repeat	424..444	CDD:275380	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810