DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and lhcgr

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_991188.1	Gene:	lhcgr / 402920	ZFINID:	ZDB-GENE-040806-3	Length:	708	Species:	Danio rerio

Alignment Length:	708	Identity:	165/708 - (23%)
Similarity:	264/708 - (37%)	Gaps:	189/708 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LTLNMTCDIVTY--PKACQCGQGTILYCGRYAKLRRFPRLSSEVTNLIIIRNNLTLRDNIFANFT 179
            |.|...|..|.:  |:.|:|.|.:|. |                       |:.|      .:..
Zfish    11 LLLTSFCCGVCFECPEICRCSQKSIT-C-----------------------NSAT------GSQK 45

  Fly   180 RLQKLTLKYNNISRVPLGSFSGLFHLERLELSH-NNVSHLPHGVFLGLHSLQWLFLVN-NHLHHL 242
            .|.:|.|.|.::..:...||.||..:.|:|::. ::|..:....|..|.::..:.:.| .:|.|:
Zfish    46 SLSRLVLNYISVKTISSRSFDGLKGVRRIEIAQSSSVETIESEAFNNLPNVSEISIQNTRNLVHI 110

  Fly   243 PVEQLRFFRRLEWLVLSRNRLTLRNVQLPKIPTLYEVY-LDFNRIEYIGEETFSQLDNLHLLDLQ 306
               |.|.|.:|..|    ..|::.|..:...|.|..:: |:.:.|..|       .|||:|..:.
Zfish   111 ---QQRAFNQLPKL----RYLSISNTGISVFPDLTSIFSLEAHFILDI-------CDNLNLRSVP 161

  Fly   307 HNLIT-----------------HIHGRAFAN-------LTNMRDIRLV-GNPIKELSGETFL--H 344
            .|..|                 .|...||..       |.|.||:|:| .:..|...|.|.|  .
Zfish   162 SNAFTGMTSEYATMNLFNNGFQEIESHAFNGTKIDKLVLKNSRDLRVVHEDAFKGALGPTVLDVS 226

  Fly   345 NTRLEALSLALMPIH-ISSSLMEPLNISFL--------NLTGIRYDHIDFE-------------- 386
            :|.||.|     |.| :.|.||.....:|.        :|..:|...:.|.
Zfish   227 STALETL-----PSHGLESVLMLTARSAFALKKLPPLKSLKSLREAQLTFPSHCCALINWDNSRD 286

  Fly   387 -AINS-MRNLTYIIYDRFFYC--SMTP-------------------------------------- 409
             ::|| :||       |..||  :.:|
Zfish   287 GSVNSALRN-------RSSYCGDNSSPADLSAISSDDSLESDVIGSSSVEDTFGSIDFHYPDLDL 344

  Fly   410 ----RVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIR 470
                :...|.|..|..:..:|:.....||.:.|.:..|.||||::||...|..|.:......::.
Zfish   345 CQQRQALQCSPEADAFNPCEDIAGFSFLRVAIWFINILAIAGNLVVLLVLFTSRCKLTVPRFLMC 409

  Fly   471 NLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLER 535
            :||.||:.:|.||:.|...|.|.|..|....::|.|...|.:.|.|:|...|:|:..|:.:::||
Zfish   410 HLAFADLCIGIYLLMIATVDLRTRGHYSHHAIEWQTGAGCDIAGFLSVFGGELSIYTLSTITVER 474

  Fly   536 FLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYS--GTCFPLHIHE 598
            :..|....|..|.:|.....|.:...|:..:.:|:.|::        ...|||  ..|.|:.|..
Zfish   475 WHTITHALRLERRLGLSQASLIMTIGWLLCLAMALLPLI--------GVSSYSKVSMCLPMDIET 531

  Fly   599 AFPMGWLYSAFVF-LGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFL 662
            .....::....:| :|..|::......:|:|:....:..|:|      |.:.|.|...::.||||
Zfish   532 PLSQAYVILLLLFNVGAFLVICGCYVCIYSAVRNPEFPGRAA------DAKIAKRMAVLIFTDFL 590

  Fly   663 CWVPIIVMKIWVFF--------NYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYR 712
            |..||....|...|        |..|       |:|...|:||..||.||...|..:|
Zfish   591 CMAPISFFAISAAFKVPLITVTNSKI-------LLVLFYPINSCANPFLYAIFTRAFR 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	14/61 (23%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	47/187 (25%)
		leucine-rich repeat	205..228	CDD:275380	5/23 (22%)
		leucine-rich repeat	229..252	CDD:275380	6/23 (26%)
		leucine-rich repeat	253..275	CDD:275380	4/21 (19%)
		LRR_8	274..334	CDD:290566	20/85 (24%)
		leucine-rich repeat	276..299	CDD:275380	4/23 (17%)
		leucine-rich repeat	300..323	CDD:275380	8/46 (17%)
		leucine-rich repeat	324..347	CDD:275380	8/25 (32%)
		7tm_1	447..704	CDD:278431	71/267 (27%)
lhcgr	NP_991188.1	leucine-rich repeat	47..70	CDD:275380	8/22 (36%)
		LRR_5	58..216	CDD:290045	39/171 (23%)
		leucine-rich repeat	71..95	CDD:275380	5/23 (22%)
		leucine-rich repeat	96..120	CDD:275380	7/26 (27%)
		leucine-rich repeat	121..142	CDD:275380	5/24 (21%)
		leucine-rich repeat	143..170	CDD:275380	9/33 (27%)
		leucine-rich repeat	171..194	CDD:275380	3/22 (14%)
		leucine-rich repeat	195..219	CDD:275380	7/23 (30%)
		leucine-rich repeat	220..257	CDD:275380	12/41 (29%)
		GnHR_trans	283..356	CDD:289164	9/79 (11%)
		7tm_1	386..633	CDD:278431	71/267 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810