DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and LHCGR

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_000224.2	Gene:	LHCGR / 3973	HGNCID:	6585	Length:	699	Species:	Homo sapiens

Alignment Length:	683	Identity:	152/683 - (22%)
Similarity:	256/683 - (37%)	Gaps:	162/683 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 LQKLTLKYNNISRVPLGSFSGLFHLERLELSH-NNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPV 244
            |.:|:|.|..:..:|..:|.||..:.::|:|. :::..:....|..|.:|..:.:.|       .
Human    51 LTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQN-------T 108

  Fly   245 EQLRFFRRLEWLVLSRNR-LTLRNVQLPKIPTLYEVYLDFNRIEYIGEETF--SQLDNLHLLDLQ 306
            :.||:.....::.|.|.: |::.|..:.|.|.:.:|        :..|..|  ...||||
Human   109 KNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKV--------FSSESNFILEICDNLH----- 160

  Fly   307 HNLITHIHGRAFANLTNMR-DIRLVGNPIKELSGETF------------------LHN------- 345
               ||.|.|.||..:.|.. .::|.||..:|:....|                  :||
Human   161 ---ITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGAT 222

  Fly   346 ---------TRLEAL------SLALMPIHISSSLME-PLNISFLNLTGIRYDHIDFEAI------ 388
                     |:|:||      |:..:....|.||.: |...:|:||         .||.
Human   223 GPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNL---------LEATLTYPSH 278

  Fly   389 --------NSMRNLTYIIYDRF---------------FYCSM----------------TPRVRMC 414
                    ...:|.::.|.:.|               .|.||                .|:...|
Human   279 CCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRC 343

  Fly   415 KPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLM 479
            .|..|..:..:|::....||...|::..|.|.||:.||:.....|.:......::.||:.||..|
Human   344 APEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCM 408

  Fly   480 GFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFR 544
            |.||:.|...|.:.:.:||...:||.|...|:..|...|.:||:|:..|..::|||:..|.....
Human   409 GLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIH 473

  Fly   545 GHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAFPMGWLYSAF 609
            ..:.:..|...|.::..|:....:|:.|::     .:..|...| .|||:.:.......::.:..
Human   474 LDQKLRLRHAILIMLGGWLFSSLIAMLPLV-----GVSNYMKVS-ICFPMDVETTLSQVYILTIL 532

  Fly   610 VFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWV 674
            :   :|::...:|...|..:..::  .......|..|.:.|.:...::.|||.|..||....|..
Human   533 I---LNVVAFFIICACYIKIYFAV--RNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISA 592

  Fly   675 FF--------NYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRKRAE- 730
            .|        |..:       |:|...|:||..||.||...|..::...||...|....::|||
Human   593 AFKVPLITVTNSKV-------LLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAEL 650

  Fly   731 -------AGNGNVATTTTGTATGSSQHPDDFTI 756
                   |...|.....||     |..|...|:
Human   651 YRRKDFSAYTSNCKNGFTG-----SNKPSQSTL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	14/58 (24%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	43/202 (21%)
		leucine-rich repeat	205..228	CDD:275380	4/23 (17%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		leucine-rich repeat	253..275	CDD:275380	5/22 (23%)
		LRR_8	274..334	CDD:290566	18/62 (29%)
		leucine-rich repeat	276..299	CDD:275380	3/24 (13%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	324..347	CDD:275380	7/57 (12%)
		7tm_1	447..704	CDD:278431	63/264 (24%)
LHCGR	NP_000224.2	leucine-rich repeat	51..74	CDD:275380	8/22 (36%)
		LRR_5	62..198	CDD:290045	37/158 (23%)
		leucine-rich repeat	75..99	CDD:275380	4/23 (17%)
		LRR 1	96..115		5/25 (20%)
		leucine-rich repeat	100..124	CDD:275380	5/30 (17%)
		LRR 2	124..145		6/28 (21%)
		leucine-rich repeat	125..150	CDD:275380	6/32 (19%)
		LRR 3	149..171		11/29 (38%)
		leucine-rich repeat	151..174	CDD:275380	11/30 (37%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		LRR 4	175..196		5/20 (25%)
		LRR 5	198..220		2/21 (10%)
		leucine-rich repeat	199..223	CDD:275380	2/23 (9%)
		LRR 6	223..244		4/20 (20%)
		leucine-rich repeat	224..244	CDD:275380	4/19 (21%)
		7tm_1	376..623	CDD:278431	63/264 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810