DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and Rxfp2

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001012493.1	Gene:	Rxfp2 / 363866	RGDID:	1309449	Length:	737	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	255/759 - (33%)
Similarity:	387/759 - (50%)	Gaps:	106/759 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LMTVVLLLAAVIFYLS----LGP-CPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLL 72
            |:.||||:....|.|:    :.| ||...|.|.|.|.|:||...||..:||.:.:||:  .||
  Rat     4 LLHVVLLMEVKDFTLAGSNMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADED--NCG-- 64

  Fly    73 YGSKEIADKIVRNAIEKKQQRLISAVSNASGADSTTSMVPRN-QSLTLNMTCDIVTYPKACQCGQ 136
                                       :.||..:....|..| ..:||...|.:..||:.|.|.:
  Rat    65 ---------------------------DTSGWTTIFGTVHGNVNKVTLTEECFLSRYPQHCYCRE 102

  Fly   137 GTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSFS 200
            .. |.|.. |.|:..|::||.||.|.:.:|.: .|...:|:.:..|:|:.|::|.|:.:...:|.
  Rat   103 NE-LECVN-ADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAFL 165

  Fly   201 GLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFL------------------------VNNHLHH 241
            ||.:|:.|.||||.::.|..|:|..||.|.||.|                        |:|.|..
  Rat   166 GLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQRSFTGLNSLFFLSMVSNRLEA 230

  Fly   242 LPVEQLRFFRRLEWLVLSRNRLT-LRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDL 305
            ||........:|.|:.|:.|.:. :.|.......:|..::|..|:|.::.|:|||.|.||..|||
  Rat   231 LPERLCAQMPQLNWVDLANNGIKFITNSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDL 295

  Fly   306 QHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSSLMEPLNI 370
            ..|:|..:....|::|..::.:.|..||:      .::|..:..:|.                .:
  Rat   296 SSNVIAKLPAHLFSDLHLLQKLNLSSNPL------LYVHKNQFGSLK----------------QL 338

  Fly   371 SFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRY 435
            ..|:|..|...:|:......|:||::|....|.|||..|.||:|.|||||:||.:|||:..:||.
  Rat   339 QSLDLERIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANSILRV 403

  Fly   436 SAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKV 500
            |.||:|.:|.|||.||:..|.:.:.||....|.|:.|..||.|||.||.::||.|.:||.:|.|.
  Rat   404 SVWVIAFITCAGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKY 468

  Fly   501 VLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITG 565
            .|.|:.|..|.|:|.||..|:|||:|:|.|::||:||:|..||...| :|.|...:.|..||:.|
  Rat   469 ALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLR-LGKRQTAVVLASIWVAG 532

  Fly   566 VGLAVAPVLLWRTSTLPYYGSY---SGTCFPLHIHEAFPMGWL-YSAFVFLGVNLLLLVMIAMLY 626
            ..:|..|.     ::..|:|::   :|.|||||..:|...|.. ||..:|||||||..::|...|
  Rat   533 FLIAAVPF-----TSEDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVITFSY 592

  Fly   627 TALLISIWRT--RSATPLTLLDCEFAV--RFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAW 687
            ..:..||.:|  ::|...:.:..|.||  ||||||.:|.:||:|:.|:||.......|...|.:|
  Rat   593 VTMFCSIQKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSW 657

  Fly   688 LVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRKRAEA 731
            :|||.||:|||:||:|||.||..:::::     |::..:.|.::
  Rat   658 IVVFFLPVNSALNPILYTLTTSLFKDKL-----KQLLHKHRRKS 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	14/32 (44%)
		LRR_8	179..239	CDD:290566	25/83 (30%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	51/182 (28%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	9/46 (20%)
		leucine-rich repeat	253..275	CDD:275380	5/22 (23%)
		LRR_8	274..334	CDD:290566	20/59 (34%)
		leucine-rich repeat	276..299	CDD:275380	9/22 (41%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tm_1	447..704	CDD:278431	109/264 (41%)
Rxfp2	NP_001012493.1	LDLa	28..63	CDD:238060	15/36 (42%)
		leucine-rich repeat	96..121	CDD:275380	8/26 (31%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		LRR_RI	134..343	CDD:238064	59/230 (26%)
		LRR_8	145..204	CDD:290566	23/58 (40%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		leucine-rich repeat	170..193	CDD:275380	10/22 (45%)
		LRR_8	193..252	CDD:290566	13/58 (22%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		LRR_8	265..324	CDD:290566	20/58 (34%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		LRR_8	314..367	CDD:290566	13/74 (18%)
		leucine-rich repeat	314..337	CDD:275380	5/44 (11%)
		leucine-rich repeat	338..357	CDD:275380	4/18 (22%)
		7tm_1	415..674	CDD:278431	109/264 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3175
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15402
Inparanoid	1	1.050	382	1.000	Inparanoid score	I1980
OMA	1	1.010	-	-		QHG47748
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	1	1.000	-	-		otm45151
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840