DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and LRRC57

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_694992.2	Gene:	LRRC57 / 255252	HGNCID:	26719	Length:	239	Species:	Homo sapiens

Alignment Length:	174	Identity:	51/174 - (29%)
Similarity:	82/174 - (47%)	Gaps:	22/174 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 LRRFP----RLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLER 207
            |..||    :|:|.:..:.:..|.: :|...:...||.|:.|:|..|.::.:| .....|..||.
Human    26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLP-DEICNLKKLET 89

  Fly   208 LELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQLPK 272
            |.|::|::..|| ..|..|.:|:.|.|..|.|..|| .||...|.|:.:.||:|       |:..
Human    90 LSLNNNHLRELP-STFGQLSALKTLSLSGNQLGALP-PQLCSLRHLDVMDLSKN-------QIRS 145

  Fly   273 IP------TLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLI 310
            ||      .:.|:.|:.|:|..|..: .|....|.:|.|:.|.:
Human   146 IPDSVGELQVIELNLNQNQISQISVK-ISCCPRLKILRLEENCL 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	20/59 (34%)
		leucine-rich repeat	181..204	CDD:275380	6/22 (27%)
		LRR_RI	<196..354	CDD:238064	37/121 (31%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		leucine-rich repeat	253..275	CDD:275380	7/27 (26%)
		LRR_8	274..334	CDD:290566	11/43 (26%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		leucine-rich repeat	300..323	CDD:275380	4/11 (36%)
		leucine-rich repeat	324..347	CDD:275380
		7tm_1	447..704	CDD:278431
LRRC57	NP_694992.2	PRK15370	<21..>211	CDD:185268	51/174 (29%)
		LRR 1	39..60		2/20 (10%)
		leucine-rich repeat	40..63	CDD:275380	3/22 (14%)
		LRR 2	63..84		5/21 (24%)
		leucine-rich repeat	64..86	CDD:275380	6/22 (27%)
		LRR 3	86..107		8/21 (38%)
		leucine-rich repeat	87..109	CDD:275380	9/22 (41%)
		LRR 4	109..131		9/22 (41%)
		leucine-rich repeat	110..132	CDD:275380	9/22 (41%)
		LRR 5	132..153		7/27 (26%)
		leucine-rich repeat	133..154	CDD:275380	7/27 (26%)
		LRR 6	154..175		6/21 (29%)
		leucine-rich repeat	155..177	CDD:275380	6/22 (27%)
		LRR 7	177..197		4/12 (33%)
		leucine-rich repeat	178..199	CDD:275380	4/11 (36%)
		LRR 8	202..222
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4149
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030