DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and Lhcgr

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_037110.1	Gene:	Lhcgr / 25477	RGDID:	3007	Length:	700	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	149/705 - (21%)
Similarity:	250/705 - (35%)	Gaps:	189/705 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PKACQCGQGTILYC-GRYAKLRRFPRLSSEVTNLIIIRNNLTLRDNIFANFTRLQKLTL-KYNNI 191
            |:.|.|.....|.| |..|.|.|.     .:|.|.:    ..:....|.....:.|:.: :.:::
  Rat    35 PEPCDCAPDGALRCPGPRAGLARL-----SLTYLPV----KVIPSQAFRGLNEVVKIEISQSDSL 90

  Fly   192 SRVPLGSFSGLFHLERLELSH-NNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEW 255
            .|:...:|..|.:|..|.:.: .|:.::..|.|..|..|::|.:.|..:..||
  Rat    91 ERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLP------------ 143

  Fly   256 LVLSRNRLTLRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFAN 320
                         .:.||.:     .:||.|..|       .||||        ||.|.|.||..
  Rat   144 -------------DVTKISS-----SEFNFILEI-------CDNLH--------ITTIPGNAFQG 175

  Fly   321 LTNMR-DIRLVGNPIKELSGETFLHNTRLEALSLA----LMPIHISSSLMEPLNISFLNLTGIRY 380
            :.|.. .::|.||..:|:....| :.|.|.:|.|.    |..:| |.:.......|.|:::..:.
  Rat   176 MNNESVTLKLYGNGFEEVQSHAF-NGTTLISLELKENIYLEKMH-SGAFQGATGPSILDISSTKL 238

  Fly   381 DHIDFEAINSM--------------------------------------------RNLTYIIYDR 401
            ..:....:.|:                                            :|.::.|::.
  Rat   239 QALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFEN 303

  Fly   402 FF---------------------------------YCSMTPRVRMCKPSTDGVSSFQDLLSKPVL 433
            |.                                 :||  |:...|.|..|..:..:|::....|
  Rat   304 FSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCS--PKTLQCAPEPDAFNPCEDIMGYAFL 366

  Fly   434 RYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYY 498
            |...|::..|.|.||:.||:.....|.:......::.||:.||..||.||:.|...|.:.:.:||
  Rat   367 RVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYY 431

  Fly   499 KVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWI 563
            ...:||.|...|...|...|.:||:|:..|..::|||:..|....:..:.:..|
  Rat   432 NHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLR----------- 485

  Fly   564 TGVGLAVAPVLL--WRTSTL----PYYG--SYS--GTCFPLHIHEAFPMGWLYSAFVFLGVNLLL 618
                 ...|::|  |..|||    |..|  :|.  ..|.|:.:.......::.|..:   :|::.
  Rat   486 -----HAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILI---LNVVA 542

  Fly   619 LVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFF------- 676
            .|:|...|..:..::.......|..  |.:.|.:...::.|||.|..||....|...|
  Rat   543 FVVICACYIRIYFAVQNPELTAPNK--DTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITV 605

  Fly   677 -NYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRKRAE 730
             |..|       |:|...|:||..||.||...|..::....|...:....::|||
  Rat   606 TNSKI-------LLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	13/61 (21%)
		leucine-rich repeat	181..204	CDD:275380	4/23 (17%)
		LRR_RI	<196..354	CDD:238064	38/159 (24%)
		leucine-rich repeat	205..228	CDD:275380	6/23 (26%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		leucine-rich repeat	253..275	CDD:275380	2/21 (10%)
		LRR_8	274..334	CDD:290566	18/60 (30%)
		leucine-rich repeat	276..299	CDD:275380	4/22 (18%)
		leucine-rich repeat	300..323	CDD:275380	8/22 (36%)
		leucine-rich repeat	324..347	CDD:275380	5/23 (22%)
		7tm_1	447..704	CDD:278431	68/274 (25%)
Lhcgr	NP_037110.1	leucine-rich repeat	55..78	CDD:275380	5/31 (16%)
		LRR_5	66..204	CDD:404228	39/183 (21%)
		leucine-rich repeat	79..103	CDD:275380	4/23 (17%)
		leucine-rich repeat	104..128	CDD:275380	6/23 (26%)
		LRR 1	126..150		8/48 (17%)
		leucine-rich repeat	129..150	CDD:275380	7/45 (16%)
		LRR 2	152..175		14/37 (38%)
		leucine-rich repeat	155..178	CDD:275380	12/37 (32%)
		LRR 3	176..200		6/24 (25%)
		leucine-rich repeat	179..202	CDD:275380	5/23 (22%)
		LRR 4	202..224		6/22 (27%)
		leucine-rich repeat	203..227	CDD:275380	6/24 (25%)
		LRR 5	225..248		2/22 (9%)
		leucine-rich repeat	228..248	CDD:275380	2/19 (11%)
		LRR 6	250..271		0/20 (0%)
		7tmA_LHCGR	365..638	CDD:320481	76/300 (25%)
		TM helix 1	366..390	CDD:320481	9/23 (39%)
		TM helix 2	399..420	CDD:320481	8/20 (40%)
		TM helix 3	444..466	CDD:320481	6/21 (29%)
		TM helix 4	489..505	CDD:320481	6/15 (40%)
		TM helix 5	529..552	CDD:320481	5/25 (20%)
		TM helix 6	572..594	CDD:320481	7/21 (33%)
		TM helix 7	606..631	CDD:320481	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810