DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr3 and Tshr

DIOPT Version :10

Sequence 1:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_037020.2 Gene:Tshr / 25360 RGDID:3911 Length:764 Species:Rattus norvegicus


Alignment Length:752 Identity:172/752 - (22%)
Similarity:278/752 - (36%) Gaps:183/752 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 CQCGQ--GTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISR 193
            |:|.|  ...:.|   .:|.|.|.|......|.:|..:| |:....|::..          ||||
  Rat    29 CECHQEDDFRVTC---KELHRIPSLPPSTQTLKLIETHLKTIPSLAFSSLP----------NISR 80

  Fly   194 VPLGSFSGLFHLERLE-LSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLV 257
            :.|...:   .|:||| .|..|:|.:.|.......||  .::..:.|..||:  |:|        
  Rat    81 IYLSIDA---TLQRLEPHSFYNLSKMTHIEIRNTRSL--TYIDPDALTELPL--LKF-------- 130

  Fly   258 LSRNRLTLRNVQLPKIPTLYEVY-------LDFNRIEY---IGEETFSQLDNLHL-LDLQHNLIT 311
                 |.:.|..|...|.|.::|       |:.....|   :.|..|..|.|..| |.|.:|..|
  Rat   131 -----LGIFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFT 190

  Fly   312 HIHGRAFANLTNMRDIRLVGNPI-----KELSGETFLHNTRLEALSLALMPI------HISSSLM 365
            .|.|.|| |.|.:..:.|..|..     |:..|..:...|.|:..|.::..:      |:...:.
  Rat   191 SIQGHAF-NGTKLDAVYLNKNKYLTAIDKDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIA 254

  Fly   366 E--------PLNISFLNLT---------------------------------------------- 376
            :        ||::|||:||                                              
  Rat   255 KNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNVMR 319

  Fly   377 ---------GIRYDHIDFEAINSMR----NLTYII------------------------------ 398
                     |:..:|:.::..:..:    |..|.:                              
  Rat   320 GPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSH 384

  Fly   399 YDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENV 463
            || :..|.....: :|.|.:|..:..:|::....||...|.::.:.:.|||.||   |:....:.
  Rat   385 YD-YTVCGDNEDM-VCTPKSDEFNPCEDIMGYKFLRIVVWFVSLMALLGNVFVL---FVLLTSHY 444

  Fly   464 AVTM---VIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSM 525
            .:|:   ::.|||.||..||.||:.|...|.....|||...:||.|...|...|...|.:||:|:
  Rat   445 KLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPGCNTAGFFTVFASELSV 509

  Fly   526 LILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGT 590
            ..|..::|||:..|....|..|.|..|..:..:...|::...||:.|::     .:..|...| .
  Rat   510 YTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMV-----GISSYAKVS-I 568

  Fly   591 CFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFF 655
            |.|:....  |:...|.|.|.| :|::..|::...|..:.|:: |.....|.. .|.:.|.|...
  Rat   569 CLPMDTDT--PLALAYIALVLL-LNVVAFVIVCSCYVKIYITV-RNPQYNPRD-KDTKIAKRMAV 628

  Fly   656 IVLTDFLCWVPIIVMKIWVFFNYNI----SDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIF 716
            ::.|||:|..||....:....|..:    :..|   |:|...||||..||.||...|..::..:|
  Rat   629 LIFTDFMCMAPISFYALSALMNKPLITVTNSKI---LLVLFYPLNSCANPFLYAIFTKAFQRDVF 690

  Fly   717 LRGWKKITSRKRAEAGNGNVATTTTGTATGSSQHPDD 753
            :...|....:.:|:|...........|.....:.|.|
  Rat   691 ILLSKFGLCKHQAQAYQAQRVCPNNNTGIQIQKIPQD 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr3NP_733115.1 LDLa 32..65 CDD:238060
LRR 85..389 CDD:443914 73/345 (21%)
leucine-rich repeat 181..204 CDD:275380 5/22 (23%)
leucine-rich repeat 205..228 CDD:275380 8/23 (35%)
leucine-rich repeat 229..252 CDD:275380 6/22 (27%)
leucine-rich repeat 253..275 CDD:275380 3/21 (14%)
leucine-rich repeat 276..299 CDD:275380 7/32 (22%)
leucine-rich repeat 300..323 CDD:275380 10/23 (43%)
leucine-rich repeat 324..347 CDD:275380 4/27 (15%)
7tmA_Relaxin_R 431..715 CDD:320265 83/290 (29%)
TM helix 1 432..458 CDD:320265 9/25 (36%)
TM helix 2 465..490 CDD:320265 11/27 (41%)
TM helix 3 510..540 CDD:320265 10/29 (34%)
TM helix 4 552..574 CDD:320265 5/21 (24%)
TM helix 5 603..632 CDD:320265 7/28 (25%)
TM helix 6 644..674 CDD:320265 9/29 (31%)
TM helix 7 683..708 CDD:320265 11/24 (46%)
TshrNP_037020.2 leucine-rich repeat 54..77 CDD:275380 5/32 (16%)
LRR_5 65..221 CDD:463839 48/186 (26%)
leucine-rich repeat 78..102 CDD:275380 10/26 (38%)
LRR 1 100..124 5/25 (20%)
leucine-rich repeat 103..127 CDD:275380 5/25 (20%)
LRR 2 125..150 10/39 (26%)
leucine-rich repeat 128..177 CDD:275380 13/61 (21%)
LRR 3 151..174 4/22 (18%)
LRR 4 176..199 10/23 (43%)
leucine-rich repeat 180..201 CDD:275380 10/21 (48%)
LRR 5 201..223 3/21 (14%)
leucine-rich repeat 202..229 CDD:275380 4/26 (15%)
LRR 6 225..248 3/22 (14%)
leucine-rich repeat 230..251 CDD:275380 3/20 (15%)
LRR 7 264..288 7/23 (30%)
7tmA_TSH-R 415..689 CDD:320630 83/290 (29%)
TM helix 1 416..442 CDD:320630 9/28 (32%)
TM helix 2 449..474 CDD:320630 10/24 (42%)
TM helix 3 494..524 CDD:320630 10/29 (34%)
TM helix 4 536..558 CDD:320630 5/21 (24%)
TM helix 5 578..607 CDD:320630 7/29 (24%)
TM helix 6 617..647 CDD:320630 9/30 (30%)
TM helix 7 657..682 CDD:320630 11/27 (41%)
PDZ-binding 762..764
Blue background indicates that the domain is not in the aligned region.

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