DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and Tshr

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_035778.3	Gene:	Tshr / 22095	MGIID:	98849	Length:	764	Species:	Mus musculus

Alignment Length:	762	Identity:	176/762 - (23%)
Similarity:	281/762 - (36%)	Gaps:	203/762 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 CQCGQ--GTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISR 193
            |:|.|  ...:.|   .:|.|.|.|......|.:|..:| |:....|::..          ||||
Mouse    29 CECHQEDDFRVTC---KELHRIPSLPPSTQTLKLIETHLKTIPSLAFSSLP----------NISR 80

  Fly   194 VPLGSFSGLFHLERLE-LSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLV 257
            :.|...:   .|:||| .|..|:|.:.|.......||  .::..:.|..||:  |:|
Mouse    81 IYLSIDA---TLQRLEPHSFYNLSKMTHIEIRNTRSL--TYIDPDALTELPL--LKF-------- 130

  Fly   258 LSRNRLTLRNVQLPKIPTLYEVY-------LDFNRIEY---IGEETFSQLDNLHL-LDLQHNLIT 311
                 |.:.|..|...|.|.::|       |:.....|   :.|..|..|.|..| |.|.:|..|
Mouse   131 -----LGIFNTGLRIFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFT 190

  Fly   312 HIHGRAFANLTNMRDIRLVGNPIKEL------------SGETFLHNTRLEALSLALMPI----HI 360
            .:.|.|| |.|.:..:.|  |..|.|            ||.|.|.   :.:.|:..:|.    |:
Mouse   191 SVQGHAF-NGTKLDAVYL--NKNKYLTAIDNDAFGGVYSGPTLLD---VSSTSVTALPSKGLEHL 249

  Fly   361 SSSLME--------PLNISFLNLT--------------------GIRYDHIDFEAI----NSMRN 393
            ...:.:        ||::|||:||                    ||      .|::    :|:||
Mouse   250 KELIAKDTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGI------LESLMCNESSIRN 308

  Fly   394 LT------------------------------------------YIIYDR--------------- 401
            |.                                          |:.::.
Mouse   309 LRQRKSVNILRGPIYQEYEEDPGDNSVGYKQNSKFQESPSNSHYYVFFEEQEDEVVGFGQELKNP 373

  Fly   402 -------------FFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLW 453
                         :..|.....: :|.|.:|..:..:|::....||...|.::.|.:.||:.||
Mouse   374 QEETLQAFESHYDYTVCGDNEDM-VCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVL- 436

  Fly   454 GRFIYRDENVAVTM---VIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGT 515
              .|....:..:|:   ::.|||.||..||.||:.|...|....:|||...:||.|...|...|.
Mouse   437 --LILLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGF 499

  Fly   516 LAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTST 580
            ..|.:||:|:..|..::|||:..|....|..|.|..|..:..:...|::...||:.|::     .
Mouse   500 FTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMV-----G 559

  Fly   581 LPYYGSYSGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLL 645
            :..|...| .|.|:....  |:...|...|.| :|::..|::...|..:.|:: |.....|.. .
Mouse   560 ISSYAKVS-ICLPMDTDT--PLALAYIVLVLL-LNVVAFVVVCSCYVKIYITV-RNPQYNPRD-K 618

  Fly   646 DCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNI----SDDIYAWLVVFVLPLNSAVNPLLYTF 706
            |.:.|.|...::.|||:|..||....:....|..:    :..|   |:|...||||..||.||..
Mouse   619 DTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKI---LLVLFYPLNSCANPFLYAI 680

  Fly   707 TTPKYRNQIFLRGWKKITSRKRAEAGNGNVATTTTGTATGSSQHPDD 753
            .|..::..:|:...|....:::|:|..|........|.....:.|.|
Mouse   681 FTKAFQRDVFILLSKFGICKRQAQAYQGQRVCPNNSTGIQIQKIPQD 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	15/60 (25%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		LRR_RI	<196..354	CDD:238064	47/181 (26%)
		leucine-rich repeat	205..228	CDD:275380	8/23 (35%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..275	CDD:275380	3/21 (14%)
		LRR_8	274..334	CDD:290566	21/70 (30%)
		leucine-rich repeat	276..299	CDD:275380	7/32 (22%)
		leucine-rich repeat	300..323	CDD:275380	9/23 (39%)
		leucine-rich repeat	324..347	CDD:275380	8/34 (24%)
		7tm_1	447..704	CDD:278431	75/263 (29%)
Tshr	NP_035778.3	leucine-rich repeat	54..77	CDD:275380	5/32 (16%)
		LRR_5	65..221	CDD:290045	48/188 (26%)
		leucine-rich repeat	78..102	CDD:275380	10/26 (38%)
		LRR 1	100..124		5/25 (20%)
		leucine-rich repeat	103..127	CDD:275380	5/25 (20%)
		LRR 2	125..150		10/39 (26%)
		leucine-rich repeat	128..152	CDD:275380	8/36 (22%)
		LRR 3	151..174		4/22 (18%)
		leucine-rich repeat	153..177	CDD:275380	5/23 (22%)
		LRR 4	176..199		9/23 (39%)
		leucine-rich repeat	181..201	CDD:275380	8/20 (40%)
		LRR 5	200..223		5/24 (21%)
		leucine-rich repeat	202..226	CDD:275380	4/25 (16%)
		LRR 6	225..248		6/25 (24%)
		LRR 7	264..288		7/23 (30%)
		7tm_4	423..>556	CDD:304433	42/135 (31%)
		7tm_1	431..678	CDD:278431	75/263 (29%)
		PDZ-binding	762..764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810