DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and fshr

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001001812.1	Gene:	fshr / 195820	ZFINID:	ZDB-GENE-020423-5	Length:	668	Species:	Danio rerio

Alignment Length:	685	Identity:	164/685 - (23%)
Similarity:	267/685 - (38%)	Gaps:	129/685 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 YCGRYAKLRRFPRLSSEVTNLIIIRNNLTLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHL 205
            :|......|.|..|.::|         |.:...|..|.|.::   :|...||.....:.|.|..|
Zfish    27 FCAFNGSTRSFVCLGNKV---------LEIPRRIPTNTTFVE---IKLTQISVFRRAALSELHEL 79

  Fly   206 ERLELSHNN-VSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQ 269
            :|:.:|.|. :..:....|..|..|:.:.:..:       :.|...:...|.:.....||:.|..
Zfish    80 KRIVVSENGALERIEALAFFNLTELEEITITKS-------KNLVMHKDAFWRLPKLRYLTISNTG 137

  Fly   270 LPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNL-ITHIHGRAFANLTN--MRDIRLVG 331
            |..:|       ||::|.....|        .|.|||.|: |..|...||..|||  :.::||..
Zfish   138 LKILP-------DFSKINSAALE--------FLFDLQDNMHIERIPSNAFLGLTNATITELRLTK 187

  Fly   332 NPIKELSGETF------------------------------------------LHNTRLEALSLA 354
            |.|:|:....|                                          |..:.|:.|.|
Zfish   188 NGIREIDSHAFNGTKIGKLFLMGNQQLNHIHSYAFKGAEGPVVLDISRTAVHTLPESMLKTLKL- 251

  Fly   355 LMPIHISSSLMEPLNISFLNLT--GIRY-DHI----DFEAINSMRNLTYII--------YDRFF- 403
            ||.:.:.|....|....|..||  .:.| .|.    :|:...|::|....:        :..||
Zfish   252 LMAVSVYSLRKLPSLELFTELTQANLTYPSHCCAFKNFKKHKSVKNQMCNVTGAHEEPDFFNFFN 316

  Fly   404 -YCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTM 467
             :|.....| .|.|:.|..:..:|::....||...|.::.|.|.||.:||......|.:......
Zfish   317 DHCKDVIEV-TCYPTPDAFNPCEDIMGFTFLRVLIWFISVLAIVGNTVVLLVLLTSRYKLTVPRF 380

  Fly   468 VIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMS 532
            ::.:||.||:.||.||:.|...|...::.||...:||.|...|.:.|...|.|||:|:..|..::
Zfish   381 LMCHLAFADLCMGIYLLLIAAVDIHTQSRYYNYGIDWQTGAGCHVAGFFTVFSSELSVYTLTAIT 445

  Fly   533 LERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYG--SYSGT--CFP 593
            |||:..|....:..|.:..|...|.:...|:..:..|:          :|.:|  |||.|  |.|
Zfish   446 LERWHTITYAMQLERQMRLRHACLVMATGWLFSLLAAL----------MPMFGVSSYSKTSICLP 500

  Fly   594 LHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVL 658
            :.:......|::   .:.|.:|....:::.:.||.:.::: |..:..|.. .|...|.|...::.
Zfish   501 MDVETLLSQGYV---VLLLLLNAAAFLVVCVCYTLIYLTV-RNPAFVPAN-ADMRIAKRMAVLIF 560

  Fly   659 TDFLCWVPIIVMKIWVFFNYNISDDIYA-WLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKK 722
            |||||..||....|...|...:....:| .|:|...|:||..||.||.|.|..::...|:
Zfish   561 TDFLCMAPISFFAISAAFKLPLITASHAKVLLVLFYPINSCSNPFLYAFFTKTFKRDFFI----- 620

  Fly   723 ITSR-----KRAEAGNGNVATTTTGTATGSSQHPD 752
            :|||     :||......:::...|....|.:..|
Zfish   621 LTSRFGCFKRRAHIYCTEISSGQNGAVVPSPKTSD 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	13/60 (22%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		LRR_RI	<196..354	CDD:238064	41/203 (20%)
		leucine-rich repeat	205..228	CDD:275380	6/23 (26%)
		leucine-rich repeat	229..252	CDD:275380	2/22 (9%)
		leucine-rich repeat	253..275	CDD:275380	5/21 (24%)
		LRR_8	274..334	CDD:290566	20/62 (32%)
		leucine-rich repeat	276..299	CDD:275380	4/22 (18%)
		leucine-rich repeat	300..323	CDD:275380	10/23 (43%)
		leucine-rich repeat	324..347	CDD:275380	7/64 (11%)
		7tm_1	447..704	CDD:278431	72/261 (28%)
fshr	NP_001001812.1	leucine-rich repeat	79..103	CDD:275380	6/23 (26%)
		LRR_5	93..224	CDD:290045	32/152 (21%)
		leucine-rich repeat	104..127	CDD:275380	3/29 (10%)
		leucine-rich repeat	128..151	CDD:275380	8/29 (28%)
		leucine-rich repeat	152..177	CDD:275380	11/32 (34%)
		leucine-rich repeat	180..202	CDD:275380	6/21 (29%)
		leucine-rich repeat	203..227	CDD:275380	0/23 (0%)
		leucine-rich repeat	228..251	CDD:275380	3/22 (14%)
		leucine-rich repeat	252..274	CDD:275380	6/21 (29%)
		7tm_1	360..607	CDD:278431	72/261 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810