DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and Fshr

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_038551.3	Gene:	Fshr / 14309	MGIID:	95583	Length:	692	Species:	Mus musculus

Alignment Length:	693	Identity:	177/693 - (25%)
Similarity:	264/693 - (38%)	Gaps:	184/693 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 CQCGQGTILYCGRYAKLRRFPRLSSEVTNL--IIIRNNLTLRDNIFANFTRLQKLTLKYNNISRV 194
            |.|..            |.|....|:||.:  .:.||.:.||      |. |.||.:       :
Mouse    23 CHCSN------------RVFLCQDSKVTEIPPDLPRNAIELR------FV-LTKLRV-------I 61

  Fly   195 PLGSFSGLFHLERLELSHNNV---------SHLP--HGV---------------FLGLHSLQWLF 233
            |.|||||...||::|:|.|:|         |:||  |.:               |..|.||::|.
Mouse    62 PKGSFSGFGDLEKIEISQNDVLEVIEADVFSNLPNLHEIRIEKANNLLYINPEAFQNLPSLRYLL 126

  Fly   234 LVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQLPKIPTLYEVYLDFN---RIEYIGEETFS 295
            :.|..:.|||.                         ..||.:|.:|.||..   .|..|...:|.
Mouse   127 ISNTGIKHLPA-------------------------FHKIQSLQKVLLDIQDNINIHIIARNSFM 166

  Fly   296 QLD-NLHLLDLQHNLITHIHGRAFANLTNMRDIRLV-GNPIKELSGETF---------------- 342
            .|. ...:|.|..|.|..||..|| |.|.:.::.|. .|.::||..:.|
Mouse   167 GLSFESVILWLNKNGIQEIHNCAF-NGTQLDELNLSDNNNLEELPDDVFQGASGPVVLDISRTKV 230

  Fly   343 --LHNTRLEAL---------------SLALMPIHISSSLMEPLN-ISFLN-------LTGIRYDH 382
              |.|..||.|               ||....:.|.:||..|.: .:|.|       |..|....
Mouse   231 YSLPNHGLENLKKLRARSTYRLKKLPSLDKFVMLIEASLTYPSHCCAFANWRRQTSELHPICNKS 295

  Fly   383 IDFEAINSMR------------NLTY-----IIYDRFFY--CSMTPRVRMCKPSTDGVSSFQDLL 428
            |..:.|:.|.            ..:|     ::|..|.|  |:....| .|.|..|..:..:|::
Mouse   296 ISRQDIDDMTQPGDQRVSLVDDEPSYGKGSDMLYSEFDYDLCNEFVDV-TCSPKPDAFNPCEDIM 359

  Fly   429 SKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTM---VIRNLALADMLMGFYLVTIGVQD 490
            ...:||...|.::.|.|.||..||   .:.......:|:   ::.|||.||:.:|.||:.|...|
Mouse   360 GYNILRVLIWFISILAITGNTTVL---VVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVD 421

  Fly   491 YRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMW 555
            ...:::|:...:||.|...|...|...|.:||:|:..||.::|||:..|....:    :..:|..
Mouse   422 IHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLAAITLERWHTITHAMQ----LECKVQL 482

  Fly   556 LALICIWITGVGLAVAPVLLWRTSTLPYYG--SYS--GTCFPLHIHEAFPMGWLYSAFVFLGVNL 616
            .....|.:.|...|.|..|      .|.:|  ||.  ..|.|:.|..  |:..|| ....|.:|.
Mouse   483 CHAASIMVLGWAFAFAAAL------FPIFGISSYMKVSICLPMDIDS--PLSQLY-VMALLVLNA 538

  Fly   617 LLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNIS 681
            |..|:|...||.:.:::......:  :..|.:.|.|...::.|||||..||:      ||..:.|
Mouse   539 LAFVVICGCYTHIYLTVRNPNIVS--SSRDTKIAKRMATLIFTDFLCMAPIL------FFAISAS 595

  Fly   682 DDI-------YAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFL 717
            ..:       ...|:|...|:||..||.||...|..:|...|:
Mouse   596 LKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFV 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	25/85 (29%)
		leucine-rich repeat	181..204	CDD:275380	9/22 (41%)
		LRR_RI	<196..354	CDD:238064	55/221 (25%)
		leucine-rich repeat	205..228	CDD:275380	12/48 (25%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..275	CDD:275380	2/21 (10%)
		LRR_8	274..334	CDD:290566	20/64 (31%)
		leucine-rich repeat	276..299	CDD:275380	8/26 (31%)
		leucine-rich repeat	300..323	CDD:275380	9/22 (41%)
		leucine-rich repeat	324..347	CDD:275380	7/41 (17%)
		7tm_1	447..704	CDD:278431	74/270 (27%)
Fshr	NP_038551.3	LRRNT	17..45	CDD:279764	7/33 (21%)
		leucine-rich repeat	48..71	CDD:275380	12/36 (33%)
		LRR 1	49..72		12/36 (33%)
		LRR_8	72..132	CDD:290566	16/59 (27%)
		leucine-rich repeat	72..96	CDD:275380	8/23 (35%)
		LRR 2	73..97		8/23 (35%)
		leucine-rich repeat	97..121	CDD:275380	3/23 (13%)
		LRR 3	98..118		2/19 (11%)
		LRR 4	119..143		10/48 (21%)
		leucine-rich repeat	122..143	CDD:275380	8/45 (18%)
		leucine-rich repeat	144..172	CDD:275380	8/27 (30%)
		LRR 5	144..169		7/24 (29%)
		LRR 6	170..192		8/22 (36%)
		leucine-rich repeat	173..194	CDD:275380	9/21 (43%)
		LRR_8	193..245	CDD:290566	11/51 (22%)
		LRR 7	193..216		6/22 (27%)
		leucine-rich repeat	195..219	CDD:275380	5/23 (22%)
		LRR 8	217..240		3/22 (14%)
		leucine-rich repeat	220..243	CDD:275380	5/22 (23%)
		LRR 9	241..259		2/17 (12%)
		GnHR_trans	282..348	CDD:289164	12/66 (18%)
		7tm_1	378..625	CDD:278431	74/270 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810