DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and Lgr5

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	873	Identity:	174/873 - (19%)
Similarity:	289/873 - (33%)	Gaps:	319/873 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCG-QGTILYCGRYAKLRRFPRLSSEVTNLIII 164
            |:|:......:||.        |     |..|.|. .|.:|.           |:......|..:
Mouse    20 AAGSSPGPDAIPRG--------C-----PSHCHCELDGRMLL-----------RVDCSDLGLSEL 60

  Fly   165 RNNLTLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLGLHSL 229
            .:||    ::|.::     |.|..||||::|......|..||.|.|:.|.::|:|.|.|.|||||
Mouse    61 PSNL----SVFTSY-----LDLSMNNISQLPASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSL 116

  Fly   230 QWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRL------------TLRNVQLP----------- 271
            :.|.|.||.|..:|.|.|:..|.|:.|.|..|.:            :||::.|.
Mouse   117 KVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQA 181

  Fly   272 --------------------------KIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHN-- 308
                                      .:.:|..::|..|||..:|::.|..|.:|..|||.:|
Mouse   182 FRSLSALQAMTLALNKIHHIADYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246

  Fly   309 ------------------------------------LIT-HIHGR--------AFANLTNMRDIR 328
                                                ||| |.:..        ||.:|..:|.:.
Mouse   247 DEFPTAIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLT 311

  Fly   329 LVG-------------------------------------------------------------- 331
            |.|
Mouse   312 LNGASHITEFPHLTGTATLESLTLTGAKISSLPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKL 376

  Fly   332 -------NPIKELSGETFLHNTRLEALSLA-----------------LMPIHISSSLMEPL---- 368
                   |.|.|:.|.||.....|.:|:||                 |:.:.:||:|:...
Mouse   377 QKIDLRHNEIYEIKGSTFQQLFNLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTG 441

  Fly   369 --NISFLNLTGIR----------------------------------------YDHIDFEAINSM 391
              .::.|.|||.|                                        ::..|..:::.:
Mouse   442 LHGLTHLKLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQWNKDDGNSVDDL 506

  Fly   392 -------------RNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATL 443
                         |:|...:.| |...........|.||.......:.|....::|...|..|.|
Mouse   507 HKKDAGLFQVQDERDLEDFLLD-FEEDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVL 570

  Fly   444 TIAGNVLVLWGRF---IYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWI 505
            .::.|.||....|   :|..   ::.::|..:|:.|:|||.....:...|......:.:....|.
Mouse   571 ALSCNALVALTVFRTPLYIS---SIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWE 632

  Fly   506 TSWQCTLIGTLAVSSSEVSMLILAFMSLER-FLL-------IADPFRGHRSIGNRVMWLALICIW 562
            ....|.::|.|::.:||.|:.:|...:||| |.:       :..|....|:|       .|:|:.
Mouse   633 DGIGCQIVGFLSIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAI-------VLLCVL 690

  Fly   563 ITGVGLAVAPVLLWRTSTLPYYG----SYSGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIA 623
            :   .|.:|        |:|..|    :.|..|.||...|....|::. |.|.|  |.|..:::.
Mouse   691 L---ALTIA--------TIPLLGGSKYNASPLCLPLPFGEPSTTGYMV-ALVLL--NSLCFLIMT 741

  Fly   624 MLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYN-ISDDIYAW 687
            :.||.|..|:.:....   .|.||........::..:.:.:.|:..:......|.. ||.|:..:
Mouse   742 IAYTKLYCSLEKGELE---NLWDCSMVKHIALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKF 803

  Fly   688 LVVFVLPLNSAVNPLLYTFTTPKYRNQI 715
            :::.::||.|.:|||||....|.::..:
Mouse   804 ILLVIVPLPSCLNPLLYIVFNPHFKEDM 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	26/59 (44%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	62/322 (19%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		leucine-rich repeat	253..275	CDD:275380	7/70 (10%)
		LRR_8	274..334	CDD:290566	24/175 (14%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..323	CDD:275380	12/69 (17%)
		leucine-rich repeat	324..347	CDD:275380	9/91 (10%)
		7tm_1	447..704	CDD:278431	63/272 (23%)
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470	11/64 (17%)
		leucine-rich repeat	68..91	CDD:275380	8/27 (30%)
		LRR_RI	88..386	CDD:238064	55/297 (19%)
		LRR_8	92..150	CDD:290566	27/57 (47%)
		leucine-rich repeat	92..115	CDD:275380	11/22 (50%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		LRR_8	138..198	CDD:290566	8/59 (14%)
		leucine-rich repeat	140..163	CDD:275380	4/22 (18%)
		leucine-rich repeat	164..187	CDD:275380	3/22 (14%)
		LRR_8	188..246	CDD:290566	13/57 (23%)
		leucine-rich repeat	188..211	CDD:275380	0/22 (0%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	5/21 (24%)
		LRR_8	257..314	CDD:290566	9/56 (16%)
		leucine-rich repeat	259..282	CDD:275380	0/22 (0%)
		leucine-rich repeat	283..304	CDD:275380	6/20 (30%)
		LRR_8	352..410	CDD:290566	10/57 (18%)
		leucine-rich repeat	354..375	CDD:275378	0/20 (0%)
		leucine-rich repeat	376..389	CDD:275378	2/12 (17%)
		leucine-rich repeat	400..423	CDD:275378	4/22 (18%)
		leucine-rich repeat	445..467	CDD:275378	5/21 (24%)
		7tm_1	575..820	CDD:278431	63/271 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810