DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and Rxfp2

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	XP_011239323.1	Gene:	Rxfp2 / 140498	MGIID:	2153463	Length:	740	Species:	Mus musculus

Alignment Length:	720	Identity:	249/720 - (34%)
Similarity:	373/720 - (51%)	Gaps:	98/720 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLIS 96
            ||...|.|.|.|.|:||...||..:||.:.:||:  .||
Mouse    31 CPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADED--NCG-------------------------- 67

  Fly    97 AVSNASGADSTTSMVPRN-QSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTN 160
               :.||..:....|..| ..:||...|.:..||:.|.|.:.. |.|.: |.|:..|::||.||.
Mouse    68 ---DTSGWTTIFGTVHGNVNKVTLTQECFLSQYPQHCYCRENE-LECVK-ADLKAVPKVSSNVTL 127

  Fly   161 LIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFL 224
            |.:.:|.: .|...:|:.:|.|:|:.|::|.|:.:...:|.||.:|:.|.||||.::.|..|:|.
Mouse   128 LSLKKNKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFK 192

  Fly   225 GLHSLQWLFL------------------------VNNHLHHLPVEQLRFFRRLEWLVLSRNRLT- 264
            .||.|.||.|                        |.|.|..||........:|.|:.|:.|.:.
Mouse   193 DLHQLAWLILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQMPQLNWVDLANNGIKY 257

  Fly   265 LRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFANLTNMRDIRL 329
            :.|.......:|..::|..|:|.::.|:|||.|.||..|||..|:||.:....|::|..::.:.|
Mouse   258 ITNSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNL 322

  Fly   330 VGNPIKELSGETFLHNTRLEALSLALMPI-HISSSLMEPLNISFLNLTGIRYDHIDFEAINSMRN 393
            ..||:..:....|....:|::|.|..:.| :||:.:.:|                       |:|
Mouse   323 SSNPLLYVHKNQFGSLKQLQSLDLERIEIPNISTGMFQP-----------------------MKN 364

  Fly   394 LTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIY 458
            |::|....|.|||..|.||:|.|||||:||.:|||:..:||.|.||:|.:|..||.||:..|.:.
Mouse   365 LSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANGILRVSVWVIAFITCVGNFLVIAVRSLI 429

  Fly   459 RDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEV 523
            :.||....|.|:.|..||.|||.||.::||.|.:||.:|.|..|.|:.|..|.|:|.||..|:||
Mouse   430 KAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEV 494

  Fly   524 SMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSY- 587
            |:|:|.|::||:||:|..||...| :|.|...:||..||:.|..:|..|.     :...|:|::
Mouse   495 SVLLLTFLTLEKFLVIVFPFSNLR-LGKRQTAVALASIWVVGFLIAAVPF-----TREDYFGNFY 553

  Fly   588 --SGTCFPLHIHEAFPMGWL-YSAFVFLGVNLLLLVMIAMLYTALLISIWRT--RSATPLTLLDC 647
              :|.|||||..:|...|.. ||..:|||||||..::|.:.|..:..||.:|  ::|...:.:..
Mouse   554 GKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVIVISYVTMFCSIHKTALQTAEVRSHIGK 618

  Fly   648 EFAV--RFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPK 710
            |.||  ||||||.:|.:||:|:.|:||.......|...|.:|:|||.||:|||:||:|||.||..
Mouse   619 EVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSF 683

  Fly   711 YRNQI 715
            :::::
Mouse   684 FKDKL 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	14/32 (44%)
		LRR_8	179..239	CDD:290566	26/83 (31%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	53/182 (29%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	9/46 (20%)
		leucine-rich repeat	253..275	CDD:275380	5/22 (23%)
		LRR_8	274..334	CDD:290566	21/59 (36%)
		leucine-rich repeat	276..299	CDD:275380	9/22 (41%)
		leucine-rich repeat	300..323	CDD:275380	9/22 (41%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tm_1	447..704	CDD:278431	110/264 (42%)
Rxfp2	XP_011239323.1	LDLa	31..66	CDD:238060	15/36 (42%)
		LRR	104..353	CDD:227223	74/250 (30%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	148..207	CDD:338972	23/58 (40%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	10/22 (45%)
		leucine-rich repeat	197..220	CDD:275380	4/22 (18%)
		leucine-rich repeat	221..244	CDD:275380	5/22 (23%)
		leucine-rich repeat	245..268	CDD:275380	5/22 (23%)
		leucine-rich repeat	269..292	CDD:275380	9/22 (41%)
		leucine-rich repeat	293..316	CDD:275380	9/22 (41%)
		leucine-rich repeat	317..340	CDD:275380	4/22 (18%)
		leucine-rich repeat	341..360	CDD:275380	6/18 (33%)
		7tm_GPCRs	403..688	CDD:391938	122/290 (42%)
		TM helix 1	403..429	CDD:341315	12/25 (48%)
		TM helix 2	436..461	CDD:341315	12/24 (50%)
		TM helix 3	481..511	CDD:341315	16/29 (55%)
		TM helix 4	522..544	CDD:341315	8/26 (31%)
		TM helix 5	572..601	CDD:341315	11/28 (39%)
		TM helix 6	617..647	CDD:341315	16/29 (55%)
		TM helix 7	656..681	CDD:341315	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3235
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15402
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2018
Isobase	1	0.950	-	0	Normalized mean entropy	S5057
OMA	1	1.010	-	-		QHG47748
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	1	1.000	-	-		otm43086
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4149
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820