Protein Alignment Lgr3 and LOC1281307

DIOPT Version :10

• Sequence 1: NP_733115.1
• Gene: Lgr3 / 43098
• FlyBaseID: FBgn0039354
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: XP_061501261.1
• Gene: LOC1281307 / 1281307
• VectorBaseID: AGAMI1_003744
• Length: 786
• Species: Anopheles gambiae
• Alignment Length: 730
• Identity: 230/730 - (31%)
• Similarity: 350/730 - (47%)
• Gaps: 114/730 - (15%)

  Fly    32 CPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLIS 96
            |....|.|:|...|:.:.:.|:...||.|.|||  :||.         |.:.||..:...::..:
Mosquito    72 CEDGFFRCNNTLQCIEQSKNCNGFPDCDDGSDE--LECD---------DDVGRNYYDHYFRKRPA 125

  Fly    97 AVS--------NASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPR 153
            |::        |.:.|::|                        |:| :||.:.| .|..|...|.
Mosquito   126 AINDQLPYTPCNWNDANNT------------------------CKC-RGTDVLC-EYKGLTGLPS 164

  Fly   154 -LSSEVTNLIIIRNN--LTLRDNIFANFTRLQKLTLKYNNISRV-PL---GSFSGLFHLER---- 207
             |:||...|:.:..|  :.|..|:|..|.:|..|.|::.:|.|: |:   ||...| ||::
Mosquito   165 VLTSENVTLLDLTGNVFIELNMNVFQRFPKLSTLVLRHCSIERIEPVKLAGSIDAL-HLDQNGLT 228

  Fly   208 ---------------LELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLV 257
                           |.||.|.::.|....|:.|..|:.|.|.:|.:..|..:.|.....|..|.
Mosquito   229 TLPDDFFPPGTVLRILVLSGNRINRLGRTNFVNLEFLEELDLKDNQIDALTEDVLAPLTNLRILY 293

  Fly   258 LSRNRL-TLRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFANL 321
            |:.||| .|....:|.:.||..:.|..|:||.| |.....|.:|..|.|..||:|.|....|.||
Mosquito   294 LNNNRLRKLVPGMIPALVTLQTLSLARNQIETI-EVCALDLPSLEHLYLSENLLTVIRNDTFGNL 357

  Fly   322 TNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSSLMEPLNISFLNLTGIRYDHIDFE 386
            ||:..:.|..|.|.....:.|....:|                      :.|||.|.::|.||..
Mosquito   358 TNLVGLFLNSNKITHFELDAFSGIAKL----------------------ATLNLQGNKFDRIDRR 400

  Fly   387 AINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLV 451
            .::::.||.:|.:..|.:|.....||:|:|..||:||.:.||..||||.|.|:||.:.|.||:||
Mosquito   401 VLDNLTNLHHIHFTEFHHCKAALHVRVCEPKGDGISSNRHLLDNPVLRASVWIMAAIGIVGNLLV 465

  Fly   452 LWGRFIYRDENVAV----TMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTL 512
            |:||::....:...    ::.:|:||.:|:|||.||..|...|..:|.||.....:|..|..|..
Mosquito   466 LFGRYVVGSRSSQAHAEHSLYLRHLAASDLLMGVYLGIIATADIIFRGEYLTHDEEWRMSSICAF 530

  Fly   513 IGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWR 577
            .|.|:..|.:.|.|:|..::.:|.:.:..|.....|...||: |.|..:|......|:||:
Mosquito   531 SGFLSTLSCQSSTLLLTLVTWDRLVSVTRPLYQRSSSKTRVI-LRLAVLWGVATAAAIAPL---- 590

  Fly   578 TSTLPYYGSY----SGTCFPLHIHEAFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTRS 638
             |...|:|.:    :|.|..:|||:.:.|||.|||.:|:.||.:.|:.|.:.|..:|.:|..:|:
Mosquito   591 -SATEYFGPHFYGSNGVCLSVHIHDPYAMGWEYSAGLFILVNTVSLLFIGISYLRMLQAIRVSRN 654

  Fly   639 ATPLTLLDCE---FAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVN 700
            .|..| |:|.   .|.||..||.||.:||:|:||:|:.....|.||..:||||.|.|||:|||:|
Mosquito   655 ETRNT-LNCREKVVARRFAIIVATDCVCWMPVIVVKLVALAGYEISPSLYAWLAVLVLPINSALN 718

  Fly   701 PLLYTFTTPKYRNQI 715
            |:|||.||.:::.|:
Mosquito   719 PVLYTLTTAQFKQQL 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	11/32 (34%)
		LRR	85..389	CDD:443914	87/338 (26%)
		leucine-rich repeat	181..204	CDD:275380	9/26 (35%)
		leucine-rich repeat	205..228	CDD:275380	8/41 (20%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..275	CDD:275380	8/22 (36%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		leucine-rich repeat	300..323	CDD:275380	10/22 (45%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tmA_Relaxin_R	431..715	CDD:320265	111/294 (38%)
		TM helix 1	432..458	CDD:320265	15/25 (60%)
		TM helix 2	465..490	CDD:320265	10/28 (36%)
		TM helix 3	510..540	CDD:320265	8/29 (28%)
		TM helix 4	552..574	CDD:320265	8/21 (38%)
		TM helix 5	603..632	CDD:320265	12/28 (43%)
		TM helix 6	644..674	CDD:320265	15/32 (47%)
		TM helix 7	683..708	CDD:320265	16/24 (67%)
LOC1281307	XP_061501261.1	None