Protein Alignment Lgr3 and LOC1280330

DIOPT Version :10

• Sequence 1: NP_733115.1
• Gene: Lgr3 / 43098
• FlyBaseID: FBgn0039354
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: XP_320174.3
• Gene: LOC1280330 / 1280330
• VectorBaseID: AGAMI1_012989
• Length: 405
• Species: Anopheles gambiae
• Alignment Length: 367
• Identity: 80/367 - (21%)
• Similarity: 136/367 - (37%)
• Gaps: 107/367 - (29%)

  Fly   112 PRNQSLTLNMTCDIV-----------TYPKACQCGQGTILYCGRYAKLRRFP-RLSSEVTNLIII 164
            |.:.|...|.|.:::           |:|.|.......:|......:: .|| .:|:.|.:|
Mosquito    47 PEDYSFLTNSTEELIFDNATIGVLDLTHPLASIRPWKVVLTNSNVTRV-LFPAAMSASVVHL--- 107

  Fly   165 RNNLTLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGV------- 222
             .::.:.|..|.|.|.||.....|.:: :|...:.|.|..|:.|.::|:.:::....|
Mosquito   108 -THMGVEDVQFENNTSLQDFRADYTSL-QVVSPTVSKLLTLDILWITHSQLTNFSFDVLENSPVS 170

  Fly   223 --FL------------GL---HSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQL 270
              :|            ||   .:|:.|||..|.|..|....:....:|:.::|..||||...:.|
Mosquito   171 LLYLVGNKIELVTITPGLVCCRNLEELFLSGNQLKRLDFGTMALMSKLKTILLEGNRLTEVQLNL 235

  Fly   271 P---------------------------------KIP---------TLYEVYLDFNRIEYIGEET 293
            |                                 .:|         ||..|::..|..|:|....
Mosquito   236 PDREHQQMTVNEAGDVQTFCSWRTYYIEQEQKTQDVPRPNCTDYFATLLSVHMPRNAFEHIDFGV 300

  Fly   294 FSQLDNLHLLDLQHNLITHI----------HGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRL 348
            |..::||:.|||..|.:..:          ....||:..|:.|:.|  .|...:.. .:|::..:
Mosquito   301 FRLMNNLNSLDLTKNRLLELVATEEKVPIRLSELFASNNNISDVYL--RPFPAMKA-IYLYDNNV 362

  Fly   349 EALSLALMPIHISSSLMEPLNISFLNLTGIRYDHIDFEAINS 390
            .||::        |||.|.|:  :|||.....|..:...|||
Mosquito   363 NALNM--------SSLPEELD--YLNLVNNPLDCNELPHINS 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR	85..389	CDD:443914	77/364 (21%)
		leucine-rich repeat	181..204	CDD:275380	6/22 (27%)
		leucine-rich repeat	205..228	CDD:275380	7/46 (15%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..275	CDD:275380	9/63 (14%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		leucine-rich repeat	300..323	CDD:275380	7/32 (22%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tmA_Relaxin_R	431..715	CDD:320265
		TM helix 1	432..458	CDD:320265
		TM helix 2	465..490	CDD:320265
		TM helix 3	510..540	CDD:320265
		TM helix 4	552..574	CDD:320265
		TM helix 5	603..632	CDD:320265
		TM helix 6	644..674	CDD:320265
		TM helix 7	683..708	CDD:320265
LOC1280330	XP_320174.3	leucine-rich repeat	102..122	CDD:275380	5/23 (22%)
		leucine-rich repeat	123..145	CDD:275380	6/22 (27%)
		LRR	<140..>404	CDD:443914	59/268 (22%)
		leucine-rich repeat	148..165	CDD:275380	3/16 (19%)
		leucine-rich repeat	169..193	CDD:275380	3/23 (13%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..282	CDD:275380	9/63 (14%)
		leucine-rich repeat	283..306	CDD:275380	6/22 (27%)
		leucine-rich repeat	307..330	CDD:275380	5/22 (23%)
		leucine-rich repeat	331..351	CDD:275380	6/21 (29%)
		leucine-rich repeat	352..373	CDD:275380	6/29 (21%)