DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr3 and RXFP2

DIOPT Version :10

Sequence 1:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_570718.1 Gene:RXFP2 / 122042 HGNCID:17318 Length:754 Species:Homo sapiens


Alignment Length:745 Identity:255/745 - (34%)
Similarity:381/745 - (51%) Gaps:101/745 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 FCLMTVVLLLAAVIFYLSLG-----PCPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECG 70
            |.|:..::|:....|.|:.|     .|....|.|.|.|.|:||...||.::||.:.:||.  .||
Human    19 FFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEE--NCG 81

  Fly    71 LLYGSKEIADKIVRNAIEKKQQRLISAVSNASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCG 135
            ...|...|...:..||                            .|:.|...|.:..||:.|.|.
Human    82 DTSGWATIFGTVHGNA----------------------------NSVALTQECFLKQYPQCCDCK 118

  Fly   136 QGTILYCGRYAKLRRFPRLSSEVTNLIIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSF 199
            : |.|.|.. ..|:..|.:|:.||.|.:.:|.: :|.|.:|..:|:|:|:.|::|.|..:...:|
Human   119 E-TELECVN-GDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAF 181

  Fly   200 SGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFL------------------------VNNHLH 240
            .||.:|:.|.|:||.::.|..|:|..||.|.||.|                        |||:|.
Human   182 FGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLE 246

  Fly   241 HLPVEQLRFFRRLEWLVLSRNRLT-LRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLD 304
            .||.:......:|.|:.|..||:. |.|.......:|..::|..|:|.::.|:|||.|.||..||
Human   247 ALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELD 311

  Fly   305 LQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSSLMEPLN 369
            |..|.||.:....|.:|..::.:.|..||:      .:||..:.|:|.                .
Human   312 LSSNTITELSPHLFKDLKLLQKLNLSSNPL------MYLHKNQFESLK----------------Q 354

  Fly   370 ISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLR 434
            :..|:|..|...:|:......|:||::|.:..|.|||..|.||:|.|.|||:|||:|||:..:||
Human   355 LQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILR 419

  Fly   435 YSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYK 499
            ...||:|.:|..||:.|:..|...:.||....|.|:.|..||.|||.||..:|:.|.:||.:|.|
Human   420 IFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQK 484

  Fly   500 VVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWIT 564
            ..|.|:.|.||.|:|.||:.|:|||:|:|.:::||:||:|..||...|. |.|...:.|||||:.
Human   485 YALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRP-GKRQTSVILICIWMA 548

  Fly   565 GVGLAVAPVLLWRTSTLPYYGSY---SGTCFPLHIHEAFPMGWL-YSAFVFLGVNLLLLVMIAML 625
            |..:||.|  .|...   |:|::   :|.||||:..:...:|.. ||..:|||||||..::|...
Human   549 GFLIAVIP--FWNKD---YFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFS 608

  Fly   626 YTALLISIWRTRSATPLTLLDC---EFAV--RFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIY 685
            |..:..||.:|...| ..:.:|   |.||  ||||||.:|.:||:|:.|:||...|...|.|.:.
Human   609 YITMFCSIQKTALQT-TEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMT 672

  Fly   686 AWLVVFVLPLNSAVNPLLYTFTTPKYRNQI 715
            :|:|:|.||:|||:||:|||.||..:::::
Human   673 SWIVIFFLPVNSALNPILYTLTTNFFKDKL 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr3NP_733115.1 LDLa 32..65 CDD:238060 13/32 (41%)
LRR 85..389 CDD:443914 88/329 (27%)
leucine-rich repeat 181..204 CDD:275380 8/22 (36%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 10/46 (22%)
leucine-rich repeat 253..275 CDD:275380 7/22 (32%)
leucine-rich repeat 276..299 CDD:275380 9/22 (41%)
leucine-rich repeat 300..323 CDD:275380 9/22 (41%)
leucine-rich repeat 324..347 CDD:275380 5/22 (23%)
7tmA_Relaxin_R 431..715 CDD:320265 121/292 (41%)
TM helix 1 432..458 CDD:320265 10/25 (40%)
TM helix 2 465..490 CDD:320265 11/24 (46%)
TM helix 3 510..540 CDD:320265 15/29 (52%)
TM helix 4 552..574 CDD:320265 10/21 (48%)
TM helix 5 603..632 CDD:320265 12/29 (41%)
TM helix 6 644..674 CDD:320265 17/34 (50%)
TM helix 7 683..708 CDD:320265 13/24 (54%)
RXFP2NP_570718.1 LDLa 45..80 CDD:238060 14/36 (39%)
LRR <128..370 CDD:443914 76/263 (29%)
LRR 1 138..159 7/20 (35%)
leucine-rich repeat 139..162 CDD:275380 7/22 (32%)
LRR 2 162..183 6/20 (30%)
leucine-rich repeat 163..186 CDD:275380 8/22 (36%)
LRR 3 186..207 8/20 (40%)
leucine-rich repeat 187..210 CDD:275380 9/22 (41%)
LRR 4 210..231 4/20 (20%)
leucine-rich repeat 211..234 CDD:275380 4/22 (18%)
LRR 5 234..255 6/20 (30%)
leucine-rich repeat 235..258 CDD:275380 6/22 (27%)
LRR 6 258..279 7/20 (35%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
LRR 7 282..303 7/20 (35%)
leucine-rich repeat 283..306 CDD:275380 9/22 (41%)
LRR 8 306..327 9/20 (45%)
leucine-rich repeat 307..330 CDD:275380 9/22 (41%)
LRR 9 330..351 5/26 (19%)
leucine-rich repeat 331..354 CDD:275380 7/44 (16%)
LRR 10 354..375 4/20 (20%)
leucine-rich repeat 355..374 CDD:275380 4/18 (22%)
7tmA_RXFP2_LGR8 416..702 CDD:320632 121/292 (41%)
TM helix 1 417..443 CDD:320632 10/25 (40%)
TM helix 2 450..475 CDD:320632 11/24 (46%)
TM helix 3 495..525 CDD:320632 15/29 (52%)
TM helix 4 536..558 CDD:320632 10/23 (43%)
TM helix 5 586..615 CDD:320632 11/28 (39%)
TM helix 6 631..661 CDD:320632 16/29 (55%)
TM helix 7 670..695 CDD:320632 13/24 (54%)

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