DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lgr3 and rxfp1

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001177863.1	Gene:	rxfp1 / 100498669	ZFINID:	ZDB-GENE-110125-1	Length:	748	Species:	Danio rerio

Alignment Length:	709	Identity:	244/709 - (34%)
Similarity:	377/709 - (53%)	Gaps:	52/709 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLIS 96
            ||...|.|.|.:.|:|:...|:..:||.:.:||.  .||...|...:.|
Zfish    29 CPLGYFPCGNLSTCLPQVLHCNGVDDCGNQADEE--NCGDNNGWPHLFD---------------- 75

  Fly    97 AVSNASGADSTTSMVPRNQSLTLNMTCDIVTYPKACQCGQGTILYCGRYAKLRRFPRLSSEVTNL 161
               |..|       :|.|.....:..|.:.|.|..||| :...|.|.. |..:..|.:|..||.:
Zfish    76 ---NYFG-------IPSNNLGNKSDACLLGTVPAECQC-RDLELDCDG-AHFKDVPMVSINVTMM 128

  Fly   162 IIIRNNL-TLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVSHLPHGVFLG 225
            .:.||.| .|..::|..:..||||.|::|.|..|...:|.||::|.||.||:|.::.|...||..
Zfish   129 SLQRNGLRKLNADMFLKYQSLQKLYLQHNRIKSVHPQAFRGLYNLTRLYLSYNRITTLLPDVFQD 193

  Fly   226 LHSLQWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRLTLRNVQLPKIPTLYEVYLDFNRIEYIG 290
            ||.|:||.|.||.|||:........|.|..|||..|.||..:....::|.|..:.::.|::|.:|
Zfish   194 LHKLEWLILENNSLHHISSLTFSGLRSLVLLVLLNNALTKLDDICLEMPRLNWLDIEGNKMETVG 258

  Fly   291 EETFSQLDNLHLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLAL 355
            ..||...:.|.:|.||.|.|:.||.:||:.|..:.::.|..|.|:.:..:.|::...|..|:::.
Zfish   259 NVTFRSCNMLTVLVLQRNRISRIHAQAFSLLRKLGELDLSSNRIEAIPPDLFVNLGDLLQLNISY 323

  Fly   356 MPI-HISSSLMEPLN-ISFLNLTGIRYDHIDFEAINSMRNLTYIIYDRFFYCSMTPRVRMCKPST 418
            .|| ::.....:.|: :..|::.||...:|.......::|||:|.:.:|.||...|.||.|||:|
Zfish   324 NPIMNLRVDHFDKLHKLKSLSIEGIEIGNIHRRMFEPLKNLTHIYFKKFQYCGYAPYVRSCKPNT 388

  Fly   419 DGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYL 483
            ||:|||:|||:..|||...|.::..|..||:.|:..|...|.||....|.|.:|..||.|||.||
Zfish   389 DGISSFEDLLANIVLRVFVWAVSATTCFGNIFVICMRSYIRSENKLHAMCIISLCCADGLMGVYL 453

  Fly   484 VTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLIADPFRGHRS 548
            ..||..|.::|.||.:.....:.|..|.:||:||:.|:|||:|:|.:::||:::.|..||| :.:
Zfish   454 FMIGAYDLKFRGEYNRHAQAGMDSEACQVIGSLAMLSTEVSVLLLTYLTLEKYICIVYPFR-YLT 517

  Fly   549 IGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAFPMG-WLYSAFVFL 612
            :|.|.....|:.||:.|..:|..| ||::.....:||: :|.|||||..:...:| .:||..:||
Zfish   518 LGRRRTVTILVVIWVLGFIIAFLP-LLFKGVFRNFYGT-NGVCFPLHSEQPETLGAQIYSIVIFL 580

  Fly   613 GVNLLLLVMIAMLYTALLISIWRTRSAT---------PLTLLDCEFAVRFFFIVLTDFLCWVPII 668
            |:||:..::|.:.|.::..:|.||.:.|         .||:     |.|||.||:||.|||:||.
Zfish   581 GLNLVAFLIIVLSYGSMFYNIQRTGTQTTKYSNHIKKELTI-----AKRFFSIVITDSLCWIPIF 640

  Fly   669 VMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRK 727
            ::|........|...|.:|:|:|:||:|||:||:|||.||..:: :..|:.|.....|:
Zfish   641 ILKTLSLMEVEIPGTISSWVVIFILPINSALNPILYTLTTRPFK-ETLLQVWSNYRQRR 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	11/32 (34%)
		LRR_8	179..239	CDD:290566	28/59 (47%)
		leucine-rich repeat	181..204	CDD:275380	11/22 (50%)
		LRR_RI	<196..354	CDD:238064	55/157 (35%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		leucine-rich repeat	253..275	CDD:275380	7/21 (33%)
		LRR_8	274..334	CDD:290566	20/59 (34%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		leucine-rich repeat	300..323	CDD:275380	11/22 (50%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tm_1	447..704	CDD:278431	101/266 (38%)
rxfp1	NP_001177863.1	LDLa	29..64	CDD:238060	12/36 (33%)
		LRR_RI	99..304	CDD:238064	75/206 (36%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	28/58 (48%)
		leucine-rich repeat	149..172	CDD:275380	11/22 (50%)
		leucine-rich repeat	173..196	CDD:275380	10/22 (45%)
		LRR_8	196..278	CDD:290566	29/81 (36%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		leucine-rich repeat	221..243	CDD:275380	7/21 (33%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	268..326	CDD:290566	17/57 (30%)
		leucine-rich repeat	268..291	CDD:275380	11/22 (50%)
		leucine-rich repeat	292..315	CDD:275380	4/22 (18%)
		leucine-rich repeat	316..339	CDD:275380	5/22 (23%)
		leucine-rich repeat	340..361	CDD:275380	4/20 (20%)
		7tm_1	417..676	CDD:278431	101/266 (38%)
		7tm_4	<482..>616	CDD:304433	48/136 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3072
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1949
OMA	1	1.010	-	-		QHG47748
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	1	1.000	-	-		otm25686
orthoMCL	1	0.900	-	-		OOG6_101648
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980