DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lgr3 and rxfp1

DIOPT Version :9

Sequence 1:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	XP_031751332.1	Gene:	rxfp1 / 100494807	XenbaseID:	XB-GENE-985695	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	747	Identity:	251/747 - (33%)
Similarity:	368/747 - (49%)	Gaps:	105/747 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CPAASFACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKEIADKIVRNAIEKKQQRLIS 96
            ||...|.|.|.|.|:|:...|:..::|.:.:||:  .||...|..:..||:.....||
Frog    29 CPLGYFPCGNITKCLPQFMHCNGVDECGNQADED--NCGDNNGWSQQLDKLFEKHYEK------- 84

  Fly    97 AVSNASGADSTTSMVPRNQSLTLNM--------TCDIVTYPKACQCGQGTILYCGRYAKLRRFPR 153
                                :.||:        .|.:...|..|.| :|..|.|.. ||||..|.
Frog    85 --------------------IGLNVFDLEMKPSECTLGPVPTQCLC-RGLELDCDG-AKLRTVPS 127

  Fly   154 LSSEVTNLIIIRNNL--TLRDNIFANFTRLQKLTLKYNNISRVPLGSFSGLFHLERLELSHNNVS 216
            :|..|| ::.::||:  .|..:.|..|..|:||.|::|||..|.:.:|.||::|.:|.||||.::
Frog   128 VSPNVT-IMSLQNNMLRKLGPDEFRIFPDLRKLYLQHNNIRTVSVHAFKGLYNLTKLYLSHNEIT 191

  Fly   217 HLPHGVFLGLHSLQWLF------------------------LVNNHLHHLPVEQL-RFFRRLEWL 256
            .|..|||..||.|:||.                        ::||.|..||.:.| :...:|.||
Frog   192 TLKPGVFEDLHRLEWLIIENNKITRIYPQTFQGLNSLILLVMMNNFLERLPDKSLCQHMPKLNWL 256

  Fly   257 VLSRNRL-TLRNVQLPKIPTLYEVYLDFNRIEYIGEETFSQLDNLHLLDLQHNLITHIHGRAFAN 320
            ....|.: :|.|.......||..:.:..|||..|.|.|||.|..|..|||.:|.|..........
Frog   257 DFEGNNVQSLTNTTFISCATLTVLVMRRNRISTISENTFSSLYRLDELDLANNRIEAFSPSLMKG 321

  Fly   321 LTNMRDIRLVGNPIKELSGETFLHNTRLEALSLALMPIHISSSLMEPLNISFLNLTGIRYDHIDF 385
            :..:..:.:..|||:::..:.|.:..:|::||                      |.||...:|..
Frog   322 VKELSQLNISHNPIQKIQADQFDYVIKLKSLS----------------------LEGIEIPNIQR 364

  Fly   386 EAINSMRNLTYIIYDRFFYCSMTPRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVL 450
            .....::|||:|.:.:|.||...|.||.|||:|||:||.::||:..|.|...||::.:|..||:.
Frog   365 RMFMPLKNLTHIYFKKFQYCGFAPHVRNCKPNTDGISSLENLLASIVQRVFVWVVSVITCFGNIF 429

  Fly   451 VLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGT 515
            |:..|...|.||....|.|.:|..||.|||.||..||..|.:||.||.:....|:.|.||.|:|:
Frog   430 VICTRPYIRSENKLHAMSIMSLCCADCLMGVYLFVIGYFDLKYRGEYNENAQAWMDSTQCRLVGS 494

  Fly   516 LAVSSSEVSMLILAFMSLERFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTST 580
            ||:.|:|||:|:|.:::||:::.|..|||..:....|.: ..||.|||.|..:|..| |..:|..
Frog   495 LAILSTEVSVLLLTYLTLEKYICIVYPFRCLKPGKCRTI-TTLILIWIIGFVIAFIP-LSNQTFF 557

  Fly   581 LPYYGSYSGTCFPLHIHE-AFPMGWLYSAFVFLGVNLLLLVMIAMLYTALLISIWRTR-SATPL- 642
            ..|||: :|.|||||..: ......:||..:||||||...::|...|:::..||.||. .||.:
Frog   558 HNYYGT-NGVCFPLHSEQPESTAAQIYSVIIFLGVNLAAFIIIVFSYSSMFYSIHRTAIMATEIH 621

  Fly   643 --TLLDCEFAVRFFFIVLTDFLCWVPIIVMKIWVFFNYNISDDIYAWLVVFVLPLNSAVNPLLYT 705
              ...:...|.||||||.||.|||:||.::|:.......|...|.:|:|:|:||:|||:||:|||
Frog   622 NHIKKEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQVEIPGSISSWVVIFILPINSALNPILYT 686

  Fly   706 FTTPKYRNQIFLRG--WKKITSRKRAEAGNGN 735
            .||..::..|   |  |...  ::|...||.|
Frog   687 ITTRPFKEMI---GQIWSNY--KQRRSIGNRN 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	11/32 (34%)
		LRR_8	179..239	CDD:290566	28/83 (34%)
		leucine-rich repeat	181..204	CDD:275380	11/22 (50%)
		LRR_RI	<196..354	CDD:238064	54/183 (30%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	9/47 (19%)
		leucine-rich repeat	253..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	18/59 (31%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		7tm_1	447..704	CDD:278431	107/261 (41%)
rxfp1	XP_031751332.1	LDLa	29..64	CDD:238060	12/36 (33%)
		LRRNT	105..134	CDD:214470	14/31 (45%)
		PPP1R42	131..375	CDD:411060	75/266 (28%)
		leucine-rich repeat	132..155	CDD:275380	7/23 (30%)
		leucine-rich repeat	156..179	CDD:275380	11/22 (50%)
		leucine-rich repeat	180..203	CDD:275380	11/22 (50%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	228..252	CDD:275380	6/23 (26%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		leucine-rich repeat	349..370	CDD:275380	7/42 (17%)
		7tmA_RXFP1_LGR7	410..696	CDD:320631	117/288 (41%)
		TM helix 1	412..436	CDD:320631	8/23 (35%)
		TM helix 2	445..466	CDD:320631	10/20 (50%)
		TM helix 3	490..512	CDD:320631	10/21 (48%)
		TM helix 4	534..550	CDD:320631	7/15 (47%)
		TM helix 5	582..605	CDD:320631	10/22 (45%)
		TM helix 6	631..653	CDD:320631	14/21 (67%)
		TM helix 7	664..689	CDD:320631	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3202
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2072
OMA	1	1.010	-	-		QHG47748
OrthoDB	1	1.010	-	-		D256258at33208
OrthoFinder	1	1.000	-	-		FOG0002061
OrthoInspector	1	1.000	-	-		otm48216
Panther	1	1.100	-	-	O	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080