DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lgr3 and lgr5

DIOPT Version :10

Sequence 1:NP_733115.1 Gene:Lgr3 / 43098 FlyBaseID:FBgn0039354 Length:765 Species:Drosophila melanogaster
Sequence 2:XP_002940219.2 Gene:lgr5 / 100486389 XenbaseID:XB-GENE-994091 Length:902 Species:Xenopus tropicalis


Alignment Length:898 Identity:183/898 - (20%)
Similarity:322/898 - (35%) Gaps:289/898 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 PKACQCGQGTILY---CGRYAKLRRFPR-LSSEVTNLIIIRNNLT-LRDNIFANFTRLQKLTLKY 188
            |..|:|.|..:|.   |...| |...|| ||...:.|.:..||:| |..|:..|...|::|.|..
 Frog    33 PTPCECEQEGMLVRVDCSDRA-LTSLPRNLSIFTSYLDLSMNNITNLPSNVMHNLHFLEELRLAG 96

  Fly   189 NNISRVPLGSFSGL--------------------FH----LERLELSHNNVSHLPHGVFLGLHSL 229
            |:::.:|.|:|:||                    .|    |:.|.|..|::|::|...|.||.||
 Frog    97 NDLTYIPKGAFAGLGSLKVLMLQNNLLRQVPSEALHNLRSLQSLRLDANHISYVPPSSFNGLFSL 161

  Fly   230 QWLFLVNNHLHHLPVEQLRFFRRLEWLVLSRNRL------TLRNVQLPKIPTLYEVYLDFNRIEY 288
            :.|:|.:|.|..:||..|.....|:.:.|:.|::      ..||     :.:|..::|..|||..
 Frog   162 RHLWLDDNSLTEIPVRALESLSALQAMTLALNKIHHIPDYAFRN-----LSSLVVLHLHNNRIYS 221

  Fly   289 IGEETFSQLDNLHLLDLQHN--------------------------------------LIT---- 311
            :|::.|..|.:|..|||.:|                                      |||    
 Frog   222 LGKKCFDGLHSLETLDLNYNNLDEFPAAIKTLKNLKELGFHSNNIKSIPEQAFIGNPSLITIHFY 286

  Fly   312 -----HIHGRAFANLTNMRDIRLVG----NPIKELSGETFLHNTRLEALSLALMPIHISSSL--M 365
                 |:...||.:|..:|.:.|.|    ....:|:|.|.|.:..|....|..:|..:.:.|  :
 Frog   287 DNPIQHVGRSAFQHLPELRTLILNGASQITEFPDLTGTTSLESLTLTGAQLVYLPSAVCTQLPNL 351

  Fly   366 EPLNISFLNLTGI-------RYDHID-------------FEAINSMRNLTY------IIYDRFF- 403
            :.|::|:.::..:       |...||             |:.:..:|:|..      :|:...| 
 Frog   352 QVLDLSYNHIKDLPSFSGCQRLQKIDLRHNEVYEIRSTTFQQLVGLRSLDLAWNKIAVIHPNSFS 416

  Fly   404 ---------------------------YCSMT--------------PRVRM-------------- 413
                                       :..:|              |::|:              
 Frog   417 SLPSLIKLDLSSNHLTSFPVTGLHGLTHLKLTGNSALQDLIPSEHFPKLRVMEMPYAYQCCAFAV 481

  Fly   414 -------------------------------------------------------CKPSTDGVSS 423
                                                                   |.||......
 Frog   482 CDNLKHSGQMNKDENSSADDFYRKDIGLLHLQDDRDFEDFLLDFEEDVKVLHSVQCTPSAGPFKP 546

  Fly   424 FQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVIRNLALADMLMGFYLVTIGV 488
            ...|....:.|...|::..|:...|.||:...|.......::.::|..:|:.:.|||.....:..
 Frog   547 CDHLFGSWLTRTGVWLIVLLSFVCNALVIATVFRPLSYVPSIKLLIGLIAIMNTLMGLSSGVLAT 611

  Fly   489 QDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLI--ADPFRGHRSIGN 551
            .|......:.:....|.:...|.:.|.|:|.::|.|:.:|...:|||...|  ...|....|..|
 Frog   612 VDALTFGNFAQYGAWWESGVGCQITGFLSVFAAETSIFLLTVAALERGFSIKCTTKFETKSSFIN 676

  Fly   552 RVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEAFPMGWLYSAFVFLGVNL 616
              :.|:::..::..:.:||:|:|...|     ||: |..||||...:...||::. |.|.|  |.
 Frog   677 --VKLSIVFCFLLSIVIAVSPLLSGST-----YGT-SPLCFPLLFGDPSSMGFMV-ALVLL--NS 730

  Fly   617 LLLVMIAMLYTAL--------LISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLCWVPIIVMKIW 673
            |..:::.:.||.|        |.:||           ||........::.|:.:.:.|:..:...
 Frog   731 LCFLVMTIAYTKLYCSLEKGELENIW-----------DCSMVKHIALLLFTNCILYCPVAFLSFS 784

  Fly   674 VFFNYN-ISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQI-FLRGWKKITSRKRAEA----- 731
            ...|.. ||.::...:::.::||.:.:|||||....|.::..| .|:....:.||.|..:     
 Frog   785 SLLNLTFISPEVNKSILLLIIPLPACLNPLLYILFNPHFKEDIGSLKNGDILWSRSRQTSLASVS 849

  Fly   732 ------------------GNGNVATTTTGTATGSS-QHPDDFTIFAKAAMRCH 765
                              .|.:::.....|::.|| |..:::.:.|.|.:.||
 Frog   850 SEDAEKQSCDSTQALVTFANSSISYDLPATSSSSSYQMTNNYKLSAVAFVPCH 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lgr3NP_733115.1 LDLa 32..65 CDD:238060
LRR 85..389 CDD:443914 89/367 (24%)
leucine-rich repeat 181..204 CDD:275380 9/42 (21%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
leucine-rich repeat 253..275 CDD:275380 5/27 (19%)
leucine-rich repeat 276..299 CDD:275380 8/22 (36%)
leucine-rich repeat 300..323 CDD:275380 12/69 (17%)
leucine-rich repeat 324..347 CDD:275380 7/26 (27%)
7tmA_Relaxin_R 431..715 CDD:320265 69/294 (23%)
TM helix 1 432..458 CDD:320265 7/25 (28%)
TM helix 2 465..490 CDD:320265 5/24 (21%)
TM helix 3 510..540 CDD:320265 11/31 (35%)
TM helix 4 552..574 CDD:320265 4/21 (19%)
TM helix 5 603..632 CDD:320265 10/36 (28%)
TM helix 6 644..674 CDD:320265 4/29 (14%)
TM helix 7 683..708 CDD:320265 7/24 (29%)
lgr5XP_002940219.2 LRRNT 32..>61 CDD:214470 10/28 (36%)
leucine-rich repeat 65..88 CDD:275380 7/22 (32%)
LRR 89..459 CDD:443914 75/374 (20%)
leucine-rich repeat 89..112 CDD:275380 9/22 (41%)
leucine-rich repeat 113..136 CDD:275380 1/22 (5%)
leucine-rich repeat 137..160 CDD:275380 9/22 (41%)
leucine-rich repeat 161..184 CDD:275380 8/22 (36%)
leucine-rich repeat 185..208 CDD:275380 5/27 (19%)
leucine-rich repeat 209..232 CDD:275380 8/22 (36%)
leucine-rich repeat 233..255 CDD:275380 5/21 (24%)
leucine-rich repeat 256..279 CDD:275380 0/22 (0%)
leucine-rich repeat 280..301 CDD:275380 6/20 (30%)
leucine-rich repeat 327..350 CDD:275378 5/22 (23%)
leucine-rich repeat 351..372 CDD:275378 2/20 (10%)
leucine-rich repeat 373..396 CDD:275378 3/22 (14%)
leucine-rich repeat 397..420 CDD:275378 4/22 (18%)
leucine-rich repeat 421..433 CDD:275378 0/11 (0%)
7tm_GPCRs 554..827 CDD:475119 69/294 (23%)
TM helix 1 556..580 CDD:410628 6/23 (26%)
TM helix 2 589..610 CDD:410628 5/20 (25%)
TM helix 3 634..656 CDD:410628 6/21 (29%)
TM helix 4 679..695 CDD:410628 3/15 (20%)
TM helix 5 719..742 CDD:410628 8/25 (32%)
TM helix 6 761..783 CDD:410628 2/21 (10%)
TM helix 7 795..820 CDD:410628 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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