DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RASSF8 and RASSF7

DIOPT Version :9

Sequence 1:	NP_651411.1	Gene:	RASSF8 / 43096	FlyBaseID:	FBgn0261986	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_003466.1	Gene:	RASSF7 / 8045	HGNCID:	1166	Length:	373	Species:	Homo sapiens

Alignment Length:	362	Identity:	94/362 - (25%)
Similarity:	151/362 - (41%)	Gaps:	65/362 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLK 65
            |||||||:||||:||||:..||||:||.|||.|.|:.|||.|::|.|..||.|.|.|.|:.....
Human     8 MELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQAT 72

  Fly    66 WGEYANDVQFILQRSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLG--PNNNNNNKPAPTL 128
            .|::|:||||:|:|: ..:...:................::....:..||  |......:|||:|
Human    73 CGQFASDVQFVLRRT-GPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSL 136

  Fly   129 -----------------------LKQKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQ 170
                                   |:.:.|.|      ||     ||:|  |....:.:...::::
Human   137 SRPGPAAPVTPTPGCCTDLRGLELRVQRNAE------EL-----GHEA--FWEQELRREQARERE 188

  Fly   171 LQSQQTAMGAPASPPQEQLTPQDNNNVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYND----- 230
            .|::..|:.|..:....:|...|         ...::|...|.:.:....||:|.....:
Human   189 GQARLQALSAATAEHAARLQALD---------AQARALEAELQLAAEAPGPPSPMASATERLHQD 244

  Fly   231 --FYNNNSSSNQHIYSQLSKSSNELRRSSPNEMYYNNNNNIVNNNNNSPELYKQTPTISANGALV 293
              .....|:..|...:.:|::.....|:...:.......|......|..:..:||      ||.:
Human   245 LAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQT------GAAL 303

  Fly   294 PPPYRDPPPPRNSPMCQGQRLASSNADTMSNASSSTN 330
            |||   |.|.|..|..||. |..:..:::..|.|.::
Human   304 PPP---PRPDRGPPGTQGP-LPPAREESLLGAPSESH 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASSF8	NP_651411.1	UBQ	1..81	CDD:294102	46/79 (58%)
RASSF7	NP_003466.1	RA	8..86	CDD:307093	45/77 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..150		5/27 (19%)
		VirB10_like	123..>199	CDD:330184	16/88 (18%)
		SMC_N	<177..>294	CDD:330553	16/125 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..356		14/41 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1442074at2759
OrthoFinder	1	1.000	-	-		FOG0002327
OrthoInspector	1	1.000	-	-		otm40500
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15286
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850