DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RASSF8 and Rassf7

DIOPT Version :9

Sequence 1:	NP_651411.1	Gene:	RASSF8 / 43096	FlyBaseID:	FBgn0261986	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_080162.3	Gene:	Rassf7 / 66985	MGIID:	1914235	Length:	359	Species:	Mus musculus

Alignment Length:	611	Identity:	115/611 - (18%)
Similarity:	180/611 - (29%)	Gaps:	304/611 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLK 65
            |||||||:||||:||||:..||||:||.|||.|.|:.|||.|::|.|..||.|.|.|.|:.....
Mouse     8 MELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQAT 72

  Fly    66 WGEYANDVQFILQRSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLGPNNNNNNKPAPTLLK 130
            .|::||||||:|:|                              |...|....:::|.|.|
Mouse    73 CGQFANDVQFVLRR------------------------------TGPSLSGRPSSDNCPPP---- 103

  Fly   131 QKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQLQSQQTAMGAPASPPQEQLTPQDNN 195
                                            :..|.:..|..:.:|:  |...|::.||  .|.
Mouse   104 --------------------------------ERCPVRASLPPKPSAI--PGREPRKALT--FNL 132

  Fly   196 NVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYNDFYNNNSSSNQHIYSQLSKSSNELRRSSPNE 260
            ....|||
Mouse   133 RCPKLVP---------------------------------------------------------- 139

  Fly   261 MYYNNNNNIVNNNNNSPELYKQTPTISANGALVPPPYRDPPPPRNSPMCQGQRLASSNADTMSNA 325
                                  :|:|....|||.|                  :....||
Mouse   140 ----------------------SPSIPEPAALVGP------------------IPDGFAD----- 159

  Fly   326 SSSTNPFLSDYDQHSSHNTNSINNNSQAMEEGEPMFQTTQYNDLLQLIKFQREKITAQQMELQKF 390
                   |.|.:.....||..:.:
Mouse   160 -------LQDLELRIQRNTEELGH----------------------------------------- 176

  Fly   391 DTEIVYLESKERDHAHELDAISREISKADQIFRQGSEQLQTLQYVEEEN----ELVKQQEKTLKS 451
              |..:.:..:|:.|.|               |:|..:||.|.....|:    |.:..|...|::
Mouse   177 --EAFWEQELQREQARE---------------REGQARLQALSAATAEHAARLEALDAQACALEA 224

  Fly   452 EIALLR------SKLANCETELLQCKNKMRLLMDDIELEQQHQQQTNRQTVERDFLMEMERIQSE 510
            |:.|..      |..|:....|.|          |:..:::|.             :||:...:.
Mouse   225 ELRLAAEAPGPPSATASAAERLRQ----------DLATQERHS-------------LEMQGTLAL 266

  Fly   511 IDQALHNTDTSNKTADSLKKELLMIEHAIADKKRQVEQLVNEMKEVNLQSLTVTTTEEIKHLLEG 575
            :.|||.                 ..|||:..:.:::|:|..|:::.|||...
Mouse   267 VSQALE-----------------AAEHALQAQAQELEELNRELRQCNLQQFI------------- 301

  Fly   576 PNKQGSSRRIIGSPRQLETAVPTSKN 601
               |.:...:...|.||:..:|::::
Mouse   302 ---QQTGAALPPPPPQLDRTIPSTQD 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASSF8	NP_651411.1	UBQ	1..81	CDD:294102	47/79 (59%)
Rassf7	NP_080162.3	RA_RASSF7	8..90	CDD:340552	48/111 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..123		9/73 (12%)
		SMC_prok_B	<158..>334	CDD:274008	46/293 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1442074at2759
OrthoFinder	1	1.000	-	-		FOG0002327
OrthoInspector	1	1.000	-	-		otm42573
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15286
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.810