DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RASSF8 and rassf11

DIOPT Version :9

Sequence 1:	NP_651411.1	Gene:	RASSF8 / 43096	FlyBaseID:	FBgn0261986	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_021334229.1	Gene:	rassf11 / 561036	ZFINID:	ZDB-GENE-081104-201	Length:	472	Species:	Danio rerio

Alignment Length:	554	Identity:	116/554 - (20%)
Similarity:	209/554 - (37%)	Gaps:	161/554 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLK 65
            ||:||:|||:||||||||..||||:||.|||.|.|:.||:||.|::::.||:::|:|..::.|.|
Zfish     1 MEVKVYVEGVQRIVCGVTKKTTCQEVVIALAQALGRTGRYTLREKFKDYERNMSPDECLLESLEK 65

  Fly    66 WGEYANDVQFILQ-----RSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLGPNNNNNNKPA 125
            :||...:||..|:     :.|...|.:.|.::.:........:.|:.|..::.|.|.:.....|.
Zfish    66 YGEQGKEVQLTLKHIGPSQGEETNQPKAQMRRVEGPGRVRRGSGAIATLHRQSLPPLSRLCLHPE 130

  Fly   126 PTLLKQKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQLQSQQTAMGAPASPPQEQLT 190
            |...:.|.....|....|  :::|     ..:|:|  :|..||......:...|...
Zfish   131 PPTEEPKRPKRKSLTLME--EAWG-----WLENLG--RGGKQQSGRDKGKDKEGNKG-------- 178

  Fly   191 PQDNNNVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYNDFYNNNSSSNQHIYSQLSKSSNELRR 255
                                               ||::|    |:|        |..:.:.|..
Zfish   179 -----------------------------------NGHSD----NTS--------LKPTKSSLAC 196

  Fly   256 SSPNEMYYNNNNNIVNNNNNSPELYKQTPTISANGALVPPPYRDPPPPRNSPMCQGQRLASSNAD 320
            .:|.          ..:..:...:....|.||..|              |...|..:|.....|
Zfish   197 GTPQ----------TRDKKDKYRVAPHQPLISCLG--------------NRGRCCDERTVQKGA- 236

  Fly   321 TMSNASSSTNPFLSDYDQHSSHNTNSINNNSQAMEEGEPMFQTTQYNDLLQLIKFQREKITAQQM 385
                                                 |...:||  |:::.|:|...|..:.:.:
Zfish   237 -------------------------------------EEDLKTT--NEVVPLVKKSLETESEETV 262

  Fly   386 ELQKFDTEIVYLESKERDHAHELDAISREISKADQIF-----RQGSEQLQTLQYVEEE------N 439
            ||::...:         .|. .|..:.|:|...:|:.     :|.::.:......|||      |
Zfish   263 ELRRLVIQ---------QHT-SLQELKRKIESTEQLIFELENQQAAKDISETPSDEEEQLKFWIN 317

  Fly   440 ELVKQQ--EKTLKSEIALLRSKLANCETELLQCKNKMRLLMDDIELEQQ-HQQQTNRQTVERDFL 501
            ||..::  ||.|:::...::...|.|:..|...|.|:: .||...|::| ...:|..:..:.|..
Zfish   318 ELKAEEVFEKDLQNQFFEIKVAAAECKATLEDYKQKLQ-TMDLRSLQKQTGLDKTPGEISQGDAP 381

  Fly   502 MEMERIQSEIDQAL---HNTDTSNKTADSLKKEL 532
            ..::.|..:.:.:.   |.:|.:.:...:::.:|
Zfish   382 KSVQTIVKQTETSADRSHESDGTKRVVTTMESKL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASSF8	NP_651411.1	UBQ	1..81	CDD:294102	42/84 (50%)
rassf11	XP_021334229.1	TGS	1..79	CDD:330245	42/77 (55%)
rassf11	XP_021334229.1	SMC_N	<236..>380	CDD:330553	35/194 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1442074at2759
OrthoFinder	1	1.000	-	-		FOG0002327
OrthoInspector	1	1.000	-	-		otm24397
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920