DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RASSF8 and Rassf8

DIOPT Version :9

Sequence 1:	NP_651411.1	Gene:	RASSF8 / 43096	FlyBaseID:	FBgn0261986	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001178682.1	Gene:	Rassf8 / 312846	RGDID:	1308820	Length:	419	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	147/632 - (23%)
Similarity:	243/632 - (38%)	Gaps:	238/632 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLK 65
            |||||||:|:||||||||..||||:||.|||.|.|:.||:||||:||:.||||||:|||:..|.|
  Rat     1 MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPIVSLNK 65

  Fly    66 WGEYANDVQFILQRSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLGPNNNNNNKPAPTLLK 130
            ||:||:|||.||:|:                                  ||:
  Rat    66 WGQYASDVQLILRRT----------------------------------GPS------------- 83

  Fly   131 QKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQLQSQQTAMGAPASPPQEQLTPQDNN 195
                  ||.|...             |:   |..||::        .:...:.||..:|.||.:.
  Rat    84 ------LSERPTS-------------DS---VARIPER--------TLYRQSLPPLAKLRPQVDK 118

  Fly   196 NVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYNDFYNNNSSSNQHIYSQLSKSSNELRRSSPNE 260
            ::....|| .|||      |.||.     ..|..|.:.....:             |.|:
  Rat   119 SIRRREPK-RKSL------TFTGG-----AKGLTDIFGKGKET-------------EFRQ----- 153

  Fly   261 MYYNNNNNIVNNNNNSPELYKQTPTISANGALVPPPYRDPPPPRNSPMCQGQRLASSNADTMSNA 325

  Rat   154 ----------------------------------------------------------------- 153

  Fly   326 SSSTNPFLSDYDQHSSHNTNSINNNSQAMEEGEPMFQTTQYNDLLQLIKFQREKITAQQMELQKF 390
                                .:.:|.:|..|           :|.:||:.|..|:.|.:.:|:..
  Rat   154 --------------------KVLSNCRATAE-----------ELTRLIRLQTGKLQAIEKQLESS 187

  Fly   391 DTEIVYLESKERDHAHELDAISREISKADQIFRQGSEQLQTLQYVEEENELVKQQEKTLKSEIAL 455
            :.||.:.|.|..      .::..||.:.:|..::...:::..::.|.|.::.::.||.|:.::..
  Rat   188 EAEIRFWEQKYS------CSLEEEIVRLEQRIKRNDVEIEEEEFWENELQIEQENEKQLQDQLEE 246

  Fly   456 LRSKLANCETELLQCKNKMRLLMDDIELEQQHQQQTNRQTVERDFLMEMERIQSEID----QALH 516
            :|.|:|:||..|.....::..:...::.|:.|::....|..|.:...::|:::.|:|    |:|.
  Rat   247 MRQKVADCEGRLKDYLAQIHTMESGLQAEKLHREVQEAQVNEEEVKGKIEKVKGEVDLQGQQSLR 311

  Fly   517 NTDTSNKTADSLKKELLMIEHAIADKKRQVEQLVNEMKEVNLQSLTVTTTEEIKHL--------- 572
            ..:.....|.||.:....::    ||::::|||..|:::||||.....|..::..|
  Rat   312 LENGIRAVARSLGQATKRLQ----DKEQELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPTEIEA 372

  Fly   573 ------LEGP------NKQGSSRRIIGSPRQLETAVPTSKNPHGVWV 607
                  .|.|      .:.||||::..:.|.|:..|.:..||.|::|
  Rat   373 SQADIETEAPFPSGSLKRPGSSRQLPSNLRILQNPVSSGFNPEGIYV 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASSF8	NP_651411.1	UBQ	1..81	CDD:294102	56/79 (71%)
Rassf8	NP_001178682.1	RA	1..81	CDD:214612	56/113 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340739
Domainoid	1	1.000	120	1.000	Domainoid score	I5637
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3595
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1442074at2759
OrthoFinder	1	1.000	-	-		FOG0002327
OrthoInspector	1	1.000	-	-		otm44641
orthoMCL	1	0.900	-	-		OOG6_107963
Panther	1	1.100	-	-	O	PTHR15286
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5141
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760