Protein Alignment RASSF8 and RASSF8

DIOPT Version :9

• Sequence 1: NP_651411.1
• Gene: RASSF8 / 43096
• FlyBaseID: FBgn0261986
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_001158218.1
• Gene: RASSF8 / 11228
• HGNCID: 13232
• Length: 419
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 147/628 - (23%)
• Similarity: 241/628 - (38%)
• Gaps: 230/628 - (36%)

  Fly     1 MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLK 65
            |||||||:|:||||||||..||||:||.|||.|.|:.||:||||:||:.||||||:|||:..|.|
Human     1 MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPIISLNK 65

  Fly    66 WGEYANDVQFILQRSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLGPNNNNNNKPAPTLLK 130
            ||:||:|||.||:|:                                  ||:
Human    66 WGQYASDVQLILRRT----------------------------------GPS------------- 83

  Fly   131 QKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQLQSQQTAMGAPASPPQEQLTPQDNN 195
                  ||.|...             |:   |..||::        .:...:.||..:|.||.:.
Human    84 ------LSERPTS-------------DS---VARIPER--------TLYRQSLPPLAKLRPQIDK 118

  Fly   196 NVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYNDFYNNNSSSNQHIYSQLSKSSNELRRSSPNE 260
            ::....|| .|||      |.||.     ..|..|.:.....:.
Human   119 SIKRREPK-RKSL------TFTGG-----AKGLMDIFGKGKETE--------------------- 150

  Fly   261 MYYNNNNNIVNNNNNSPELYKQTPTISANGALVPPPYRDPPPPRNSPMCQGQRLASSNADTMSNA 325
                               :||
Human   151 -------------------FKQ------------------------------------------- 153

  Fly   326 SSSTNPFLSDYDQHSSHNTNSINNNSQAMEEGEPMFQTTQYNDLLQLIKFQREKITAQQMELQKF 390
                                .:.||.:           |..::|.:||:.|.||:.:.:.:|:..
Human   154 --------------------KVLNNCK-----------TTADELKKLIRLQTEKLQSIEKQLESN 187

  Fly   391 DTEIVYLESKERDHAHELDAISREISKADQIFRQGSEQLQTLQYVEEENELVKQQEKTLKSEIAL 455
            :.||.:.|.|...:..|      ||.:.:|..::...:::..::.|.|.::.::.||.||.::..
Human   188 EIEIRFWEQKYNSNLEE------EIVRLEQKIKRNDVEIEEEEFWENELQIEQENEKQLKDQLQE 246

  Fly   456 LRSKLANCETELLQCKNKMRLLMDDIELEQQHQQQTNRQTVERDFLMEMERIQSEIDQALHNTDT 520
            :|.|:..||.:|.....::|.:...:|.|:..::....|..|.:...::.:::.|||.....:..
Human   247 IRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLR 311

  Fly   521 SNKTADSLKKELLMIEHAIADKKRQVEQLVNEMKEVNLQ--------SLTVTTTE----EIKHL- 572
            ......::::.|......:.||::::|||..|:::||||        .:||...|    |..|.
Human   312 LENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHAD 376

  Fly   573 --LEGP------NKQGSSRRIIGSPRQLETAVPTSKNPHGVWV 607
              .|.|      .:.||||::..:.|.|:..:.:..||.|::|
Human   377 IEREAPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RASSF8	NP_651411.1	UBQ	1..81	CDD:294102	56/79 (71%)
RASSF8	NP_001158218.1	RA_RASSF8	2..83	CDD:340551	55/80 (69%)
		Smc	<160..>351	CDD:224117	21/190 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147073
Domainoid	1	1.000	120	1.000	Domainoid score	I5782
eggNOG	1	0.900	-	-		E1_KOG1574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3760
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1442074at2759
OrthoFinder	1	1.000	-	-		FOG0002327
OrthoInspector	1	1.000	-	-		otm40500
orthoMCL	1	0.900	-	-		OOG6_107963
Panther	1	1.100	-	-	O	PTHR15286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4258
SonicParanoid	1	1.000	-	-		X5141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790