DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANKRD44

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001354424.1 Gene:ANKRD44 / 91526 HGNCID:25259 Length:1074 Species:Homo sapiens


Alignment Length:878 Identity:245/878 - (27%)
Similarity:356/878 - (40%) Gaps:213/878 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LFEACKTGEIAKVKKLI-TPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGG 90
            |.:|..:|:..:::.|| ..:.||..|:  .|.||||.||..|..|::|.|:.|||.:.|.|...
Human    12 LVQAIFSGDPEEIRMLIHKTEDVNTLDS--EKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW 74

  Fly    91 LHPLHNCCSFGHAEVVRLLLKAGASPNTTD-NWNYTPLHEAASKGKVDVCLALLQHGANHTIRNS 154
            |.|||...:....|.|::|:|..|..|..| ||. ||||.||               ||..::.:
Human    75 LTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQ-TPLHVAA---------------ANKAVKCA 123

  Fly   155 EQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAG 219
            |.                                   ::.||:.:||    ||....|.||.||.
Human   124 EV-----------------------------------IIPLLSSVNV----SDRGGRTALHHAAL 149

  Fly   220 YNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAA 284
            ...:.:|.:|||.||:::|.||.....||.|...||.||..|||..||.|...|...:||||.||
Human   150 NGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 214

  Fly   285 SKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKL 349
            |..::.|...||:.|.:...:|.:..:|:..|.           |.|.   ||            
Human   215 SNGQINVVKHLLNLGVEIDEINVYGNTALHIAC-----------YNGQ---DA------------ 253

  Fly   350 VCAEIVNFVHPY---------TGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHL 405
                :||.:..|         .|.||||.|..|..|  ...:|||...|:.:|.::|...:|||:
Human   254 ----VVNELIDYGANVNQPNNNGFTPLHFAAASTHG--ALCLELLVNNGADVNIQSKDGKSPLHM 312

  Fly   406 AAELLHYDAMEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLTAAQ 468
            .|....:...:.|::.|.:::.:|..|.||||..||  .|..:..|::..|||....:..:....
Human   313 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLH 377

  Fly   469 LA-----SDSVLKLLKNPPD-------SETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHS 521
            ||     ||...|||.:...       |..|:|.|.                ..::..|..||  
Human   378 LAALNAHSDCCRKLLSSGQKYSIVSLFSNEHVLSAG----------------FEIDTPDKFGR-- 424

  Fly   522 TPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWK 586
            |.||.||....|..::.|...||:.:..||.|..|||.|.:..|:...|.||..|||||.:|.|.
Human   425 TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 489

  Fly   587 FTPLHEAAAK----------GKYD-----------------IC-KLLLKHGADPMKKNRDGATPA 623
            .|.||.|||.          ..:|                 :| :.||::.|:|..::::|....
Human   490 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSI 554

  Fly   624 DLV--------------------KESD----------------HDVAELL------------RGP 640
            ...                    :|||                |...|:|            :|.
Human   555 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGR 619

  Fly   641 SALLDAAKKGNLARVQRLVTP-ESINCRDAQGRNSTPLHLAAGYNNFECAEYLLE---NGADVNA 701
            :||..||.||:...|:.|:.. .||..:|...:. ||||.:....:..|...|||   |...|:.
Human   620 TALDLAAFKGHTECVEALINQGASIFVKDNVTKR-TPLHASVINGHTLCLRLLLEIADNPEAVDV 683

  Fly   702 QDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAY 766
            :|..|..||..|.:|||:|..:||::.:..|:..|..|.|.||.....|..:...:||.......
Human   684 KDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 748

  Fly   767 MKNQEGQTPIELATADDVKCLLQDAMATSLSQQ 799
            .|:..|:||:..|.|......|.:.:..:||::
Human   749 CKDSRGRTPLHYAAARGHATWLSELLQMALSEE 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 40/114 (35%)
ANK repeat 59..87 CDD:293786 14/27 (52%)
Ank_2 61..153 CDD:289560 34/92 (37%)
ANK repeat 89..120 CDD:293786 10/30 (33%)
ANK repeat 122..153 CDD:293786 9/30 (30%)
ANK 202..316 CDD:238125 43/113 (38%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
Ank_2 214..306 CDD:289560 38/91 (42%)
ANK repeat 242..273 CDD:293786 13/30 (43%)
ANK repeat 275..306 CDD:293786 11/30 (37%)
ANK 361..478 CDD:238125 39/132 (30%)
ANK repeat 363..396 CDD:293786 13/32 (41%)
Ank_2 367..459 CDD:289560 30/93 (32%)
ANK 393..573 CDD:238125 53/193 (27%)
ANK repeat 398..429 CDD:293786 6/30 (20%)
ANK repeat 431..459 CDD:293786 12/29 (41%)
ANK repeat 483..515 CDD:293786 4/38 (11%)
Ank_4 486..540 CDD:290365 12/53 (23%)
ANK 512..637 CDD:238125 48/188 (26%)
ANK repeat 522..550 CDD:293786 9/27 (33%)
Ank_2 524..616 CDD:289560 38/119 (32%)
ANK repeat 552..583 CDD:293786 14/30 (47%)
ANK repeat 585..610 CDD:293786 11/52 (21%)
ANK repeat 638..668 CDD:293786 11/30 (37%)
Ank_4 641..693 CDD:290365 16/52 (31%)
ANK 665..779 CDD:238125 35/116 (30%)
ANK repeat 672..703 CDD:293786 10/33 (30%)
Ank_2 677..769 CDD:289560 28/94 (30%)
ANK repeat 705..736 CDD:293786 11/30 (37%)
ANK repeat 738..769 CDD:293786 7/30 (23%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
ANKRD44NP_001354424.1 ANK 1 7..36 6/23 (26%)
ANK 2 40..69 14/28 (50%)
ANK 3 73..102 9/28 (32%)
ANK 4 106..135 13/79 (16%)
ANK 5 139..168 11/28 (39%)
ANK 6 172..201 13/28 (46%)
ANK 7 205..234 11/28 (39%)
ANK 8 238..267 9/58 (16%)
ANK 9 271..301 12/31 (39%)
ANK 10 305..334 6/28 (21%)
ANK 11 338..367 12/28 (43%)
ANK 13 422..451 11/30 (37%)
ANK 14 455..484 13/28 (46%)
ANK 15 488..516 8/27 (30%)
ANK 16 549..579 1/29 (3%)
ANK 17 584..613 3/28 (11%)
ANK 18 617..646 11/28 (39%)
ANK 19 651..680 9/29 (31%)
ANK 20 687..716 11/28 (39%)
ANK 21 720..749 7/28 (25%)
ANK 22 753..782 8/29 (28%)
ANK 23 789..818
ANK 24 821..850
ANK 25 856..885
ANK 26 889..919
ANK 27 923..952
ANK 28 959..988
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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